Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226250855> ?p ?o ?g. }
- W4226250855 abstract "Gypenosides (GPs), obtained from Gynostemma pentaphyllum (Thunb.) Makino, have been traditionally prescribed to treat metabolic disorders in Asians. This study assessed whether GPs could prevent lithogenic diet (LD)-induced cholesterol gallstone (CG) formation and enhance CG dissolution in mice. Gallstone-susceptible C57BL/6J mice were fed an LD or normal chow, with or without GPs. Bile acids (BAs) in gallbladder bile were analyzed by liquid chromatography-tandem mass spectrometry. Differentially expressed hepatic genes were identified by RNA sequencing, followed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. GPs were found to prevent LD-induced CG formation and to dissolve pre-existing LD-induced CGs. GPs reduced total cholesterol levels and increased BA levels in bile, as well as reducing the BA Hydrophobicity Index, ratio of 12α-hydroxylated (12α-OH) to non-12α-OH BAs, and Cholesterol Saturation Index in gallbladder bile. GO and KEGG pathway enrichment analyses indicated that GPs-induced genes were involved in BA biosynthesis and cholesterol metabolism. GPs increased the hepatic expression of genes encoding the cytochrome P450 (Cyp) enzymes Cyp7a1, Cyp7b1, and Cyp8b1, while decreasing the hepatic expression of genes encoding the adenosine triphosphate-binding cassette (Abc) transporters Abcg5 and Abcg8. GPs may be a promising strategy for preventing and dissolving CGs." @default.
- W4226250855 created "2022-05-05" @default.
- W4226250855 creator A5012102557 @default.
- W4226250855 creator A5013004225 @default.
- W4226250855 creator A5020073452 @default.
- W4226250855 creator A5028257595 @default.
- W4226250855 creator A5043226120 @default.
- W4226250855 creator A5064077225 @default.
- W4226250855 creator A5064540403 @default.
- W4226250855 creator A5074195640 @default.
- W4226250855 creator A5082856595 @default.
- W4226250855 creator A5083474463 @default.
- W4226250855 date "2022-04-04" @default.
- W4226250855 modified "2023-10-18" @default.
- W4226250855 title "Gypenosides Prevent and Dissolve Cholesterol Gallstones by Modulating the Homeostasis of Cholesterol and Bile Acids" @default.
- W4226250855 cites W1895325632 @default.
- W4226250855 cites W1943976550 @default.
- W4226250855 cites W1973188256 @default.
- W4226250855 cites W1975476980 @default.
- W4226250855 cites W1981240182 @default.
- W4226250855 cites W2004541724 @default.
- W4226250855 cites W2006152402 @default.
- W4226250855 cites W2025121222 @default.
- W4226250855 cites W2033718513 @default.
- W4226250855 cites W2035618305 @default.
- W4226250855 cites W2039988347 @default.
- W4226250855 cites W2047145984 @default.
- W4226250855 cites W2049169935 @default.
- W4226250855 cites W2070522987 @default.
- W4226250855 cites W2077534039 @default.
- W4226250855 cites W2078810890 @default.
- W4226250855 cites W2107479916 @default.
- W4226250855 cites W2114104545 @default.
- W4226250855 cites W2117674153 @default.
- W4226250855 cites W2123145802 @default.
- W4226250855 cites W2128559420 @default.
- W4226250855 cites W2134526812 @default.
- W4226250855 cites W2167917613 @default.
- W4226250855 cites W2169321302 @default.
- W4226250855 cites W2171795832 @default.
- W4226250855 cites W2176945519 @default.
- W4226250855 cites W2186126507 @default.
- W4226250855 cites W2280623704 @default.
- W4226250855 cites W2428595929 @default.
- W4226250855 cites W2520824290 @default.
- W4226250855 cites W2578045848 @default.
- W4226250855 cites W2605509833 @default.
- W4226250855 cites W2762038335 @default.
- W4226250855 cites W2776373981 @default.
- W4226250855 cites W2883323070 @default.
- W4226250855 cites W2903555694 @default.
- W4226250855 cites W2964849163 @default.
- W4226250855 cites W2967255981 @default.
- W4226250855 cites W2969623961 @default.
- W4226250855 cites W3008554522 @default.
- W4226250855 cites W3035887689 @default.
- W4226250855 cites W3087011675 @default.
- W4226250855 cites W3106217480 @default.
- W4226250855 cites W3108662553 @default.
- W4226250855 cites W3109895489 @default.
- W4226250855 cites W3129849311 @default.
- W4226250855 cites W3186697348 @default.
- W4226250855 cites W3193961220 @default.
- W4226250855 cites W4211193442 @default.
- W4226250855 doi "https://doi.org/10.3389/fmed.2022.818144" @default.
- W4226250855 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35445045" @default.
- W4226250855 hasPublicationYear "2022" @default.
- W4226250855 type Work @default.
- W4226250855 citedByCount "2" @default.
- W4226250855 countsByYear W42262508552023 @default.
- W4226250855 crossrefType "journal-article" @default.
- W4226250855 hasAuthorship W4226250855A5012102557 @default.
- W4226250855 hasAuthorship W4226250855A5013004225 @default.
- W4226250855 hasAuthorship W4226250855A5020073452 @default.
- W4226250855 hasAuthorship W4226250855A5028257595 @default.
- W4226250855 hasAuthorship W4226250855A5043226120 @default.
- W4226250855 hasAuthorship W4226250855A5064077225 @default.
- W4226250855 hasAuthorship W4226250855A5064540403 @default.
- W4226250855 hasAuthorship W4226250855A5074195640 @default.
- W4226250855 hasAuthorship W4226250855A5082856595 @default.
- W4226250855 hasAuthorship W4226250855A5083474463 @default.
- W4226250855 hasBestOaLocation W42262508551 @default.
- W4226250855 hasConcept C10213722 @default.
- W4226250855 hasConcept C104317684 @default.
- W4226250855 hasConcept C126322002 @default.
- W4226250855 hasConcept C150194340 @default.
- W4226250855 hasConcept C152724338 @default.
- W4226250855 hasConcept C185592680 @default.
- W4226250855 hasConcept C2778163477 @default.
- W4226250855 hasConcept C2779388726 @default.
- W4226250855 hasConcept C2779399885 @default.
- W4226250855 hasConcept C2987395477 @default.
- W4226250855 hasConcept C55493867 @default.
- W4226250855 hasConcept C71924100 @default.
- W4226250855 hasConcept C86803240 @default.
- W4226250855 hasConcept C89673097 @default.
- W4226250855 hasConceptScore W4226250855C10213722 @default.
- W4226250855 hasConceptScore W4226250855C104317684 @default.
- W4226250855 hasConceptScore W4226250855C126322002 @default.
- W4226250855 hasConceptScore W4226250855C150194340 @default.