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- W4226250889 abstract "Carol W. Greider (1961) is an American biochemist who, as a graduate student at the University of California, Berkeley, isolated, purified and initially characterized an enzyme that extends the non-DNA templated multiple DNA repeats at the ends of telomeres, the specialized termini of eucaryotic chromosomes that had been previously discovered by Greider’s dissertation advisor, Elizabeth Blackburn. In collaborative work, they showed that this enzyme, which they called telomerase, contains an essential RNA component that provides an RNA sequence template for the synthesis of the DNA repeats, thus showing that telomerase is a type of reverse transcriptase. Blackburn had shown that the number of repeats is variable, and Greider found that the number of repeats is related to cell senescence and eventually related the synthesis and maintenance of the telomere repeats to the failure of cancer cells to exhibit in vitro senescence described as the “Hayflick limit”. She has extended this work on the balance between telomere synthesis and loss to identify a class of conditions she has termed “telomere syndromes.” For this work, Greider was awarded a Nobel Prize or Physiology or Medicine in 2009 along with Blackburn and Jack Szostak." @default.
- W4226250889 created "2022-05-05" @default.
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- W4226250889 date "2022-01-01" @default.
- W4226250889 modified "2023-09-26" @default.
- W4226250889 title "Greider, Carol" @default.
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- W4226250889 doi "https://doi.org/10.1016/b978-0-12-822563-9.00027-5" @default.
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