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- W4226263640 abstract "RNA viruses like SARS-CoV-2, influenza virus, and respiratory syncytial virus (RSV) are dependent on host genes for replication. We investigated if probenecid, an FDA-approved and safe urate-lowering drug that inhibits organic anion transporters (OATs) has prophylactic or therapeutic efficacy to inhibit RSV replication in three epithelial cell lines used in RSV studies, i.e., Vero E6 cells, HEp-2 cells, and in primary normal human bronchoepithelial (NHBE) cells, and in BALB/c mice. The studies showed that nanomolar concentrations of all probenecid regimens prevent RSV strain A and B replication in vitro and RSV strain A in vivo, representing a potential prophylactic and chemotherapeutic for RSV." @default.
- W4226263640 created "2022-05-05" @default.
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- W4226263640 date "2022-04-27" @default.
- W4226263640 modified "2023-09-26" @default.
- W4226263640 title "Probenecid Inhibits Respiratory Syncytial Virus (RSV) Replication" @default.
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- W4226263640 doi "https://doi.org/10.3390/v14050912" @default.
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