Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226266071> ?p ?o ?g. }
- W4226266071 endingPage "110652" @default.
- W4226266071 startingPage "110652" @default.
- W4226266071 abstract "The actomyosin cortex regulates the localization and function of proteins at the plasma membrane. Here, we study how membrane binding, cortical movements, and diffusion determine membrane protein distribution. In Caenorhabditis elegans zygotes, actomyosin flows transport PAR polarity proteins to establish the anterior-posterior axis. Oligomerization of a key scaffold protein, PAR-3, is required for polarization. PAR-3 oligomers are a heterogeneous population of many different sizes, and it remains unclear how oligomer size affects PAR-3 segregation. To address this question, we engineered PAR-3 to defined sizes. We report that PAR-3 trimers are necessary and sufficient for PAR-3 function during polarization and later embryo development. Quantitative analysis of PAR-3 diffusion shows that a threshold size of three subunits allows PAR-3 clusters to stably bind the membrane, where they are corralled and transported by the actomyosin cortex. Our study provides a quantitative model for size-dependent protein transportation of peripheral membrane proteins by cortical flow." @default.
- W4226266071 created "2022-05-05" @default.
- W4226266071 creator A5009042739 @default.
- W4226266071 creator A5010553035 @default.
- W4226266071 date "2022-04-01" @default.
- W4226266071 modified "2023-10-16" @default.
- W4226266071 title "A particle size threshold governs diffusion and segregation of PAR-3 during cell polarization" @default.
- W4226266071 cites W1499336842 @default.
- W4226266071 cites W1560056935 @default.
- W4226266071 cites W1577709527 @default.
- W4226266071 cites W1834588461 @default.
- W4226266071 cites W1892733044 @default.
- W4226266071 cites W1963876867 @default.
- W4226266071 cites W1965387248 @default.
- W4226266071 cites W1976127881 @default.
- W4226266071 cites W1976603396 @default.
- W4226266071 cites W1986141440 @default.
- W4226266071 cites W1991566923 @default.
- W4226266071 cites W2004466255 @default.
- W4226266071 cites W2020955446 @default.
- W4226266071 cites W2028415754 @default.
- W4226266071 cites W2036870980 @default.
- W4226266071 cites W2046462248 @default.
- W4226266071 cites W2046831598 @default.
- W4226266071 cites W2048961736 @default.
- W4226266071 cites W2052744662 @default.
- W4226266071 cites W2060297895 @default.
- W4226266071 cites W2068920904 @default.
- W4226266071 cites W2080846265 @default.
- W4226266071 cites W2082589861 @default.
- W4226266071 cites W2101417222 @default.
- W4226266071 cites W2105916176 @default.
- W4226266071 cites W2107662757 @default.
- W4226266071 cites W2109461200 @default.
- W4226266071 cites W2117312649 @default.
- W4226266071 cites W2117612738 @default.
- W4226266071 cites W2129788878 @default.
- W4226266071 cites W2132654115 @default.
- W4226266071 cites W2143614744 @default.
- W4226266071 cites W2152764495 @default.
- W4226266071 cites W2163889515 @default.
- W4226266071 cites W2166254523 @default.
- W4226266071 cites W2514958885 @default.
- W4226266071 cites W2529049901 @default.
- W4226266071 cites W2538965655 @default.
- W4226266071 cites W2554626805 @default.
- W4226266071 cites W2605776475 @default.
- W4226266071 cites W2625678278 @default.
- W4226266071 cites W2724272189 @default.
- W4226266071 cites W2737413500 @default.
- W4226266071 cites W2742344312 @default.
- W4226266071 cites W2747562273 @default.
- W4226266071 cites W2762248661 @default.
- W4226266071 cites W2790048502 @default.
- W4226266071 cites W2810043503 @default.
- W4226266071 cites W2900950960 @default.
- W4226266071 cites W2943485734 @default.
- W4226266071 cites W2964879814 @default.
- W4226266071 cites W2982045146 @default.
- W4226266071 cites W2982653137 @default.
- W4226266071 cites W3165299462 @default.
- W4226266071 cites W3205646916 @default.
- W4226266071 cites W380346485 @default.
- W4226266071 cites W4211068691 @default.
- W4226266071 cites W4211075026 @default.
- W4226266071 cites W2320485177 @default.
- W4226266071 doi "https://doi.org/10.1016/j.celrep.2022.110652" @default.
- W4226266071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35417695" @default.
- W4226266071 hasPublicationYear "2022" @default.
- W4226266071 type Work @default.
- W4226266071 citedByCount "15" @default.
- W4226266071 countsByYear W42262660712022 @default.
- W4226266071 countsByYear W42262660712023 @default.
- W4226266071 crossrefType "journal-article" @default.
- W4226266071 hasAuthorship W4226266071A5009042739 @default.
- W4226266071 hasAuthorship W4226266071A5010553035 @default.
- W4226266071 hasBestOaLocation W42262660711 @default.
- W4226266071 hasConcept C104317684 @default.
- W4226266071 hasConcept C12554922 @default.
- W4226266071 hasConcept C125705527 @default.
- W4226266071 hasConcept C142669718 @default.
- W4226266071 hasConcept C144024400 @default.
- W4226266071 hasConcept C144647389 @default.
- W4226266071 hasConcept C1491633281 @default.
- W4226266071 hasConcept C149923435 @default.
- W4226266071 hasConcept C178790620 @default.
- W4226266071 hasConcept C185592680 @default.
- W4226266071 hasConcept C204462481 @default.
- W4226266071 hasConcept C2778944004 @default.
- W4226266071 hasConcept C2780642029 @default.
- W4226266071 hasConcept C2908647359 @default.
- W4226266071 hasConcept C41625074 @default.
- W4226266071 hasConcept C49353375 @default.
- W4226266071 hasConcept C55493867 @default.
- W4226266071 hasConcept C86803240 @default.
- W4226266071 hasConceptScore W4226266071C104317684 @default.
- W4226266071 hasConceptScore W4226266071C12554922 @default.
- W4226266071 hasConceptScore W4226266071C125705527 @default.