FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226268373> ?p ?o ?g. }

• W4226268373 endingPage "S369" @default.
• W4226268373 startingPage "S369" @default.
• W4226268373 abstract "Purpose Pediatric patients receiving heart transplantation are at increased risk of prolonged ventilation (PV). However, there is limited data on factors that predict PV post-heart transplant (HT). This study sought to determine the factors leading to PV post-HT as it could be an important outcome measure. Methods The United Network for Organ Sharing (UNOS) and the Pediatric Health Information System (PHIS) Registries were queried for pediatric patients who received HT in 2006-2020. Duration of post-HT ventilatory support was divided into those on “prolonged ventilation” (PV) (≥4 days) and those on “short-term ventilation” (SV) (<4 days). Binary logistic regression was used to identify independent predictors of PV and of reintubation. Results A total of 3092 patients were identified with a median duration of post-HT ventilation of 3 [2-8] days. 1565 (50.6%) patients were on SV and 1527 (49.4%) on PV. PV patients were younger (median 2 [0-11] years vs 9 [1-15] years, p<0.001) and more likely diagnosed with congenital heart disease (CHD) (62% vs 40%, p<0.001) compared to SV. At HT, PV patients had greater rates of ventilator (24% vs 5%, p<0.001) and extracorporeal mechanical oxygenation (ECMO) (6% vs 1%, p<0.001) requirement and more of their donors had a longer ischemic time (>4 hours) (40% vs 30%, p<0.001), and a higher ejection fraction% (EF) (65 vs 64, p=0.02). Independent predictors of PV were CHD [Odds ratio (OR)=2.5; 95% confidence interval (CI) 2.09-2.9], allograft ischemia time>4 hours [1.3; 1.1-1.6], ventilator [5; 3.8-6.8], ECMO [2.3; 1.3-3.9], VAD [1.4; 1.2-1.7] and donor EF<55% [1.5; 1.1-2] at HT. Older recipient age was associated with shorter duration [0.96; 0.95-0.97]. CHD [1.6; 1.4-1.9], ECMO [1.6; 1.1-2.4] and recipient age [1.01; 1-1.02] were associated with increased risk of reintubation. Conclusion Ischemic time and donor EF are associated with prolonged intubation, however, recipient's age, cardiopulmonary mechanical support at HT and CHD diagnosis increase the risk of prolonged ventilation and re-intubation, post-HT. Prolonged ventilation could potentially be used as an outcome measure. Pediatric patients receiving heart transplantation are at increased risk of prolonged ventilation (PV). However, there is limited data on factors that predict PV post-heart transplant (HT). This study sought to determine the factors leading to PV post-HT as it could be an important outcome measure. The United Network for Organ Sharing (UNOS) and the Pediatric Health Information System (PHIS) Registries were queried for pediatric patients who received HT in 2006-2020. Duration of post-HT ventilatory support was divided into those on “prolonged ventilation” (PV) (≥4 days) and those on “short-term ventilation” (SV) (<4 days). Binary logistic regression was used to identify independent predictors of PV and of reintubation. A total of 3092 patients were identified with a median duration of post-HT ventilation of 3 [2-8] days. 1565 (50.6%) patients were on SV and 1527 (49.4%) on PV. PV patients were younger (median 2 [0-11] years vs 9 [1-15] years, p<0.001) and more likely diagnosed with congenital heart disease (CHD) (62% vs 40%, p<0.001) compared to SV. At HT, PV patients had greater rates of ventilator (24% vs 5%, p<0.001) and extracorporeal mechanical oxygenation (ECMO) (6% vs 1%, p<0.001) requirement and more of their donors had a longer ischemic time (>4 hours) (40% vs 30%, p<0.001), and a higher ejection fraction% (EF) (65 vs 64, p=0.02). Independent predictors of PV were CHD [Odds ratio (OR)=2.5; 95% confidence interval (CI) 2.09-2.9], allograft ischemia time>4 hours [1.3; 1.1-1.6], ventilator [5; 3.8-6.8], ECMO [2.3; 1.3-3.9], VAD [1.4; 1.2-1.7] and donor EF<55% [1.5; 1.1-2] at HT. Older recipient age was associated with shorter duration [0.96; 0.95-0.97]. CHD [1.6; 1.4-1.9], ECMO [1.6; 1.1-2.4] and recipient age [1.01; 1-1.02] were associated with increased risk of reintubation. Ischemic time and donor EF are associated with prolonged intubation, however, recipient's age, cardiopulmonary mechanical support at HT and CHD diagnosis increase the risk of prolonged ventilation and re-intubation, post-HT. Prolonged ventilation could potentially be used as an outcome measure." @default.
• W4226268373 created "2022-05-05" @default.
• W4226268373 creator A5026812822 @default.
• W4226268373 creator A5028389199 @default.
• W4226268373 creator A5031306910 @default.
• W4226268373 creator A5035051474 @default.
• W4226268373 creator A5051977288 @default.
• W4226268373 creator A5055818738 @default.
• W4226268373 creator A5074283709 @default.
• W4226268373 creator A5083881992 @default.
• W4226268373 date "2022-04-01" @default.
• W4226268373 modified "2023-10-18" @default.
• W4226268373 title "Risk of Prolonged Intubation Post-Pediatric Heart Transplantation" @default.
• W4226268373 doi "https://doi.org/10.1016/j.healun.2022.01.1486" @default.
• W4226268373 hasPublicationYear "2022" @default.
• W4226268373 type Work @default.
• W4226268373 citedByCount "0" @default.
• W4226268373 crossrefType "journal-article" @default.
• W4226268373 hasAuthorship W4226268373A5026812822 @default.
• W4226268373 hasAuthorship W4226268373A5028389199 @default.
• W4226268373 hasAuthorship W4226268373A5031306910 @default.
• W4226268373 hasAuthorship W4226268373A5035051474 @default.
• W4226268373 hasAuthorship W4226268373A5051977288 @default.
• W4226268373 hasAuthorship W4226268373A5055818738 @default.
• W4226268373 hasAuthorship W4226268373A5074283709 @default.
• W4226268373 hasAuthorship W4226268373A5083881992 @default.
• W4226268373 hasBestOaLocation W42262683731 @default.
• W4226268373 hasConcept C126322002 @default.
• W4226268373 hasConcept C127413603 @default.
• W4226268373 hasConcept C151956035 @default.
• W4226268373 hasConcept C156957248 @default.
• W4226268373 hasConcept C164705383 @default.
• W4226268373 hasConcept C200457457 @default.
• W4226268373 hasConcept C2776858399 @default.
• W4226268373 hasConcept C2777080012 @default.
• W4226268373 hasConcept C2778198053 @default.
• W4226268373 hasConcept C2778716859 @default.
• W4226268373 hasConcept C2778849806 @default.
• W4226268373 hasConcept C2911091166 @default.
• W4226268373 hasConcept C42219234 @default.
• W4226268373 hasConcept C44249647 @default.
• W4226268373 hasConcept C71924100 @default.
• W4226268373 hasConcept C78085059 @default.
• W4226268373 hasConcept C78519656 @default.
• W4226268373 hasConceptScore W4226268373C126322002 @default.
• W4226268373 hasConceptScore W4226268373C127413603 @default.
• W4226268373 hasConceptScore W4226268373C151956035 @default.
• W4226268373 hasConceptScore W4226268373C156957248 @default.
• W4226268373 hasConceptScore W4226268373C164705383 @default.
• W4226268373 hasConceptScore W4226268373C200457457 @default.
• W4226268373 hasConceptScore W4226268373C2776858399 @default.
• W4226268373 hasConceptScore W4226268373C2777080012 @default.
• W4226268373 hasConceptScore W4226268373C2778198053 @default.
• W4226268373 hasConceptScore W4226268373C2778716859 @default.
• W4226268373 hasConceptScore W4226268373C2778849806 @default.
• W4226268373 hasConceptScore W4226268373C2911091166 @default.
• W4226268373 hasConceptScore W4226268373C42219234 @default.
• W4226268373 hasConceptScore W4226268373C44249647 @default.
• W4226268373 hasConceptScore W4226268373C71924100 @default.
• W4226268373 hasConceptScore W4226268373C78085059 @default.
• W4226268373 hasConceptScore W4226268373C78519656 @default.
• W4226268373 hasIssue "4" @default.
• W4226268373 hasLocation W42262683731 @default.
• W4226268373 hasOpenAccess W4226268373 @default.
• W4226268373 hasPrimaryLocation W42262683731 @default.
• W4226268373 hasRelatedWork W2037611947 @default.
• W4226268373 hasRelatedWork W2066707366 @default.
• W4226268373 hasRelatedWork W2072985819 @default.
• W4226268373 hasRelatedWork W2335988042 @default.
• W4226268373 hasRelatedWork W2747372682 @default.
• W4226268373 hasRelatedWork W2803743798 @default.
• W4226268373 hasRelatedWork W2945764153 @default.
• W4226268373 hasRelatedWork W3187758844 @default.
• W4226268373 hasRelatedWork W4317548836 @default.
• W4226268373 hasRelatedWork W4322739880 @default.
• W4226268373 hasVolume "41" @default.
• W4226268373 isParatext "false" @default.
• W4226268373 isRetracted "false" @default.
• W4226268373 workType "article" @default.