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• W4226278330 abstract "Background: Dyadic enrollment of a participant and study partner is required in mild cognitive impairment (MCI) clinical trials, despite participants being functionally independent. Research examining how the study partner requirement impacts MCI trials remains limited. Methods: Using the Alzheimer’s Disease Cooperative Study donepezil and vitamin E MCI trial data, we quantified the proportions of enrolled spouse, adult child, and other dyads. We used multinomial regression to identify which baseline participant characteristics (age, sex, race and ethnicity, apolipoprotein E ε4 status, education, residence type) were associated with dyad type. Results: Among 769 randomized dyads, 73% were spousal, 14% adult child, and 13% other dyads. Adjusting for multiple comparisons, underrepresented racial and ethnic background (eg, comparing Hispanic to non-Hispanic White participants: adult child vs. spouse odds ratio = 5.86; 95% confidence interval: 2.09, 16.5; other vs. spouse odds ratio = 4.95; 95% confidence interval: 1.83, 13.4), female sex, age, nonhouse residence, and apolipoprotein E ε4 noncarriage were each associated with a higher odds of having an adult child, as well as an other, study partner at enrollment. Discussion: Increasing participation among nonspousal dyads may facilitate more inclusive and representative MCI trial samples." @default.
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• W4226278330 date "2022-04-29" @default.
• W4226278330 modified "2023-09-29" @default.
• W4226278330 title "Dyadic Enrollment in a Phase 3 Mild Cognitive Impairment Clinical Trial" @default.
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• W4226278330 doi "https://doi.org/10.1097/wad.0000000000000506" @default.
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