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• W4226317177 abstract "<ns3:p><ns3:bold>Introduction:</ns3:bold> Multiple sclerosis (MS) is a chronic neuroinflammatory and neurodegenerative disease. MS prevalence varies geographically and is notably high in Scotland. Disease trajectory varies significantly between individuals and the causes for this are largely unclear. Biomarkers predictive of disease course are urgently needed to allow improved stratification for current disease modifying therapies and future targeted treatments aimed at neuroprotection and remyelination. Magnetic resonance imaging (MRI) can detect disease activity and underlying damage non-invasively <ns3:italic>in vivo</ns3:italic> at the micro and macrostructural level. FutureMS is a prospective Scottish longitudinal multi-centre cohort study, which focuses on deeply phenotyping patients with recently diagnosed relapsing-remitting MS (RRMS). Neuroimaging is a central component of the study and provides two main primary endpoints for disease activity and neurodegeneration. This paper provides an overview of MRI data acquisition, management and processing in FutureMS. FutureMS is registered with the Integrated Research Application System (IRAS, UK) under reference number 169955.</ns3:p><ns3:p> <ns3:bold>Methods and analysis: </ns3:bold>MRI is performed at baseline (N=431) and 1-year follow-up, in Dundee, Glasgow and Edinburgh (3T Siemens) and in Aberdeen (3T Philips), and managed and processed in Edinburgh. The core structural MRI protocol comprises T1-weighted, T2-weighted, FLAIR and proton density images. Primary imaging outcome measures are new/enlarging white matter lesions (WML) and reduction in brain volume over one year. Secondary imaging outcome measures comprise WML volume as an additional quantitative structural MRI measure, rim lesions on susceptibility-weighted imaging, and microstructural MRI measures, including diffusion tensor imaging and neurite orientation dispersion and density imaging metrics, relaxometry, magnetisation transfer (MT) ratio, MT saturation and derived g-ratio measures.</ns3:p><ns3:p> <ns3:bold>Conclusions: </ns3:bold>FutureMS aims to reduce uncertainty around disease course and allow for targeted treatment in RRMS by exploring the role of conventional and advanced MRI measures as biomarkers of disease severity and progression in a large population of RRMS patients in Scotland.</ns3:p>" @default.
• W4226317177 created "2022-05-05" @default.
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• W4226317177 date "2022-03-16" @default.
• W4226317177 modified "2023-10-14" @default.
• W4226317177 title "Rationale and design of the brain magnetic resonance imaging protocol for FutureMS: a longitudinal multi-centre study of newly diagnosed patients with relapsing-remitting multiple sclerosis in Scotland" @default.
• W4226317177 cites W1547739304 @default.
• W4226317177 cites W1990040006 @default.
• W4226317177 cites W1993448410 @default.
• W4226317177 cites W1994972002 @default.
• W4226317177 cites W2001248577 @default.
• W4226317177 cites W2001684352 @default.
• W4226317177 cites W2006096283 @default.
• W4226317177 cites W2029817323 @default.
• W4226317177 cites W2032254014 @default.
• W4226317177 cites W2046748764 @default.
• W4226317177 cites W2047152236 @default.
• W4226317177 cites W2052071504 @default.
• W4226317177 cites W2052644075 @default.
• W4226317177 cites W2065733568 @default.
• W4226317177 cites W2071881327 @default.
• W4226317177 cites W2077203280 @default.
• W4226317177 cites W2090506482 @default.
• W4226317177 cites W2094514781 @default.
• W4226317177 cites W2097351613 @default.
• W4226317177 cites W2099832063 @default.
• W4226317177 cites W2101135654 @default.
• W4226317177 cites W2105209479 @default.
• W4226317177 cites W2106685029 @default.
• W4226317177 cites W2106933931 @default.
• W4226317177 cites W2110422197 @default.
• W4226317177 cites W2116135717 @default.
• W4226317177 cites W2127890285 @default.
• W4226317177 cites W2129720713 @default.
• W4226317177 cites W2139158372 @default.
• W4226317177 cites W2139886607 @default.
• W4226317177 cites W2140571777 @default.
• W4226317177 cites W2148726987 @default.
• W4226317177 cites W2150667092 @default.
• W4226317177 cites W2151358435 @default.
• W4226317177 cites W2156590092 @default.
• W4226317177 cites W2158742097 @default.
• W4226317177 cites W2164167069 @default.
• W4226317177 cites W2172006631 @default.
• W4226317177 cites W2175340201 @default.
• W4226317177 cites W2206081712 @default.
• W4226317177 cites W2299228567 @default.
• W4226317177 cites W2341656143 @default.
• W4226317177 cites W2441939542 @default.
• W4226317177 cites W2469640626 @default.
• W4226317177 cites W2489242797 @default.
• W4226317177 cites W2515604041 @default.
• W4226317177 cites W2517883070 @default.
• W4226317177 cites W2589232523 @default.
• W4226317177 cites W2593343929 @default.
• W4226317177 cites W2615889936 @default.
• W4226317177 cites W2740992680 @default.
• W4226317177 cites W2744839370 @default.
• W4226317177 cites W2751996357 @default.
• W4226317177 cites W2766967264 @default.
• W4226317177 cites W2770930460 @default.
• W4226317177 cites W2777074421 @default.
• W4226317177 cites W2897656833 @default.
• W4226317177 cites W291418382 @default.
• W4226317177 cites W2914720734 @default.
• W4226317177 cites W2934202790 @default.
• W4226317177 cites W2943985574 @default.
• W4226317177 cites W2947427313 @default.
• W4226317177 cites W2951103577 @default.
• W4226317177 cites W2952686744 @default.
• W4226317177 cites W2953043379 @default.
• W4226317177 cites W2955687533 @default.
• W4226317177 cites W2967069002 @default.
• W4226317177 cites W2969310179 @default.
• W4226317177 cites W2970233240 @default.
• W4226317177 cites W2984787707 @default.
• W4226317177 cites W2985691347 @default.
• W4226317177 cites W2991340843 @default.
• W4226317177 cites W3006512435 @default.
• W4226317177 cites W3008600501 @default.
• W4226317177 cites W3097129804 @default.
• W4226317177 cites W3155252977 @default.

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