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- W4226317956 abstract "Background: Dengue is a common occurrence during the rainy season and can involve multiple systems including the liver. Pathophysiology of hepatic involvement includes ischaemia, direct invasion of hepatocytes by the virus and immunological factors. Liver spectrum includes increased bilirubin, aspartate transaminase(AST), alanine transaminase(ALT) and coagulopathy. It is usually considered as a part of MODS (multiorgan dysfunction spectrum) even if not associated with other systemic involvement. Aim: To determine the clinical, biochemical profile and outcome of dengue patients with acute liver failure. Methods: It was a retrospective study, including data from 2015 to 2020. Demographic data, presenting complaints and duration, day of acute liver failure (ALF) detection and duration of hospital stay were recorded. Patients were grouped as discharged or expired. Laboratory investigations analyzed were blood count, serum bilirubin, presentation and peak levels of transaminases, INR (international normalized ratio) and aPTT (activated partial thromboplastin time), creatinine, lactate and ammonia. X-ray and ultrasonography (abdomen including liver) was done in all patients. Clinically relevant alternate etiologies were ruled out. Results: ALF peaked between 5 to 6 days of disease onset. Mean duration of stay in the discharged group was 8.59 days and expired group was 3.63 days. Both groups had similar thrombocytopenia and though statistically insignificant, the AST:ALT ratio (>2), INR and aPTT values, serum creatinine were higher in the expired group and mean bilirubin and lactate were raised in the discharged group. Albumin at presentation (0.039) and duration of hospital stay (0.051) were statistically significant to determine the outcome. Higher percentage of MODS was seen in the expired group (56%). Conclusion: Serum albumin at presentation and length of stay were the statistically significant prognostic markers in our study. MODS led to higher mortality." @default.
- W4226317956 created "2022-05-05" @default.
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- W4226317956 date "2022-01-01" @default.
- W4226317956 modified "2023-10-12" @default.
- W4226317956 title "Acute Liver Failure: An Ignored Presentation in Dengue Infections" @default.
- W4226317956 doi "https://doi.org/10.1016/j.jceh.2021.10.032" @default.
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