Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226319595> ?p ?o ?g. }
- W4226319595 abstract "Engineered living materials (ELMs) are a new class of materials in which living organism incorporated into diffusive matrices uptake a fundamental role in material's composition and function. Understanding how the spatial confinement in 3D can regulate the behavior of the embedded cells is crucial to design and predict ELM's function, minimize their environmental impact and facilitate their translation into applied materials. This study investigates the growth and metabolic activity of bacteria within an associative hydrogel network (Pluronic-based) with mechanical properties that can be tuned by introducing a variable degree of acrylate crosslinks. Individual bacteria distributed in the hydrogel matrix at low density form functional colonies whose size is controlled by the extent of permanent crosslinks. With increasing stiffness and elastic response to deformation of the matrix, a decrease in colony volumes and an increase in their sphericity are observed. Protein production follows a different pattern with higher production yields occurring in networks with intermediate permanent crosslinking degrees. These results demonstrate that matrix design can be used to control and regulate the composition and function of ELMs containing microorganisms. Interestingly, design parameters for matrices to regulate bacteria behavior show similarities to those elucidated for 3D culture of mammalian cells." @default.
- W4226319595 created "2022-05-05" @default.
- W4226319595 creator A5006476838 @default.
- W4226319595 creator A5057209464 @default.
- W4226319595 creator A5077634539 @default.
- W4226319595 date "2022-04-11" @default.
- W4226319595 modified "2023-10-18" @default.
- W4226319595 title "Regulating Bacterial Behavior within Hydrogels of Tunable Viscoelasticity" @default.
- W4226319595 cites W1520777707 @default.
- W4226319595 cites W1534600025 @default.
- W4226319595 cites W1544137929 @default.
- W4226319595 cites W1990330500 @default.
- W4226319595 cites W1991383594 @default.
- W4226319595 cites W2004325260 @default.
- W4226319595 cites W2009288962 @default.
- W4226319595 cites W2010197849 @default.
- W4226319595 cites W2058077403 @default.
- W4226319595 cites W2096710736 @default.
- W4226319595 cites W2104791694 @default.
- W4226319595 cites W2148334906 @default.
- W4226319595 cites W2149879908 @default.
- W4226319595 cites W2167272025 @default.
- W4226319595 cites W2344920256 @default.
- W4226319595 cites W2345364694 @default.
- W4226319595 cites W2345850129 @default.
- W4226319595 cites W2507618556 @default.
- W4226319595 cites W2515096969 @default.
- W4226319595 cites W2554164858 @default.
- W4226319595 cites W2774528491 @default.
- W4226319595 cites W2782738274 @default.
- W4226319595 cites W2795484251 @default.
- W4226319595 cites W2800451751 @default.
- W4226319595 cites W2806117581 @default.
- W4226319595 cites W2837409195 @default.
- W4226319595 cites W2887416874 @default.
- W4226319595 cites W2897595328 @default.
- W4226319595 cites W2900643491 @default.
- W4226319595 cites W2905581164 @default.
- W4226319595 cites W2907136428 @default.
- W4226319595 cites W2942183361 @default.
- W4226319595 cites W2949139302 @default.
- W4226319595 cites W2949592134 @default.
- W4226319595 cites W2952850685 @default.
- W4226319595 cites W2953265039 @default.
- W4226319595 cites W2956776607 @default.
- W4226319595 cites W2964365993 @default.
- W4226319595 cites W2980754240 @default.
- W4226319595 cites W2989837443 @default.
- W4226319595 cites W2997424501 @default.
- W4226319595 cites W2998839559 @default.
- W4226319595 cites W3000167002 @default.
- W4226319595 cites W3004682451 @default.
- W4226319595 cites W3006887305 @default.
- W4226319595 cites W3012750582 @default.
- W4226319595 cites W3026681806 @default.
- W4226319595 cites W3033828143 @default.
- W4226319595 cites W3089844999 @default.
- W4226319595 cites W3117273886 @default.
- W4226319595 cites W3120402208 @default.
- W4226319595 cites W3136265598 @default.
- W4226319595 cites W3138209853 @default.
- W4226319595 cites W3149090762 @default.
- W4226319595 cites W3158355989 @default.
- W4226319595 cites W3161597832 @default.
- W4226319595 cites W3176258058 @default.
- W4226319595 cites W3196356748 @default.
- W4226319595 cites W3197367825 @default.
- W4226319595 cites W4206106192 @default.
- W4226319595 cites W4213020595 @default.
- W4226319595 cites W4226319595 @default.
- W4226319595 doi "https://doi.org/10.1002/advs.202106026" @default.
- W4226319595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35404519" @default.
- W4226319595 hasPublicationYear "2022" @default.
- W4226319595 type Work @default.
- W4226319595 citedByCount "24" @default.
- W4226319595 countsByYear W42263195952022 @default.
- W4226319595 countsByYear W42263195952023 @default.
- W4226319595 crossrefType "journal-article" @default.
- W4226319595 hasAuthorship W4226319595A5006476838 @default.
- W4226319595 hasAuthorship W4226319595A5057209464 @default.
- W4226319595 hasAuthorship W4226319595A5077634539 @default.
- W4226319595 hasBestOaLocation W42263195952 @default.
- W4226319595 hasConcept C106487976 @default.
- W4226319595 hasConcept C108586683 @default.
- W4226319595 hasConcept C12554922 @default.
- W4226319595 hasConcept C127413603 @default.
- W4226319595 hasConcept C14036430 @default.
- W4226319595 hasConcept C159467904 @default.
- W4226319595 hasConcept C159985019 @default.
- W4226319595 hasConcept C171250308 @default.
- W4226319595 hasConcept C173913448 @default.
- W4226319595 hasConcept C185592680 @default.
- W4226319595 hasConcept C186060115 @default.
- W4226319595 hasConcept C186541917 @default.
- W4226319595 hasConcept C188027245 @default.
- W4226319595 hasConcept C192562407 @default.
- W4226319595 hasConcept C42360764 @default.
- W4226319595 hasConcept C523546767 @default.
- W4226319595 hasConcept C54355233 @default.
- W4226319595 hasConcept C58123911 @default.