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- W4226322038 startingPage "110099" @default.
- W4226322038 abstract "Pregnancy reprograms mammary epithelial cells (MECs) to control their responses to pregnancy hormone re-exposure and carcinoma progression. However, the influence of pregnancy on the mammary microenvironment is less clear. Here, we used single-cell RNA sequencing to profile the composition of epithelial and non-epithelial cells in mammary tissue from nulliparous and parous female mice. Our analysis indicates an expansion of γδ natural killer T-like immune cells (NKTs) following pregnancy and upregulation of immune signaling molecules in post-pregnancy MECs. We show that expansion of NKTs following pregnancy is due to elevated expression of the antigen-presenting molecule CD1d on MECs. Loss of CD1d expression on post-pregnancy MECs, or overall lack of activated NKTs, results in mammary oncogenesis. Collectively, our findings illustrate how pregnancy-induced changes modulate the communication between MECs and the immune microenvironment and establish a causal link between pregnancy, the immune microenvironment, and mammary oncogenesis." @default.
- W4226322038 created "2022-05-05" @default.
- W4226322038 creator A5009827302 @default.
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- W4226322038 creator A5075514480 @default.
- W4226322038 creator A5077251665 @default.
- W4226322038 creator A5079783971 @default.
- W4226322038 date "2021-12-01" @default.
- W4226322038 modified "2023-10-15" @default.
- W4226322038 title "Parity-induced changes to mammary epithelial cells control NKT cell expansion and mammary oncogenesis" @default.
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