Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226323511> ?p ?o ?g. }
- W4226323511 abstract "Abstract The advance and stability of replication forks rely on a tight co-regulation of the processes of DNA synthesis and nucleosome assembly. We have addressed the relevance of parental histone recycling in the mechanisms of DNA damage tolerance (DDT) – homologous recombination (HR) and translesion synthesis (TLS) – that assist replication forks under conditions that block their advance. We show that mutants affected in the deposition of parental histones are impaired in the recombinational repair of the single-strand DNA gaps generated during DDT, with the defects being more severe in mutants impaired in the lagging strand-specific deposition pathway. These recombinational defects are not due to a deficit of parental histones at the nascent strands but to an excess of parental nucleosomes at the invaded strand that destabilizes the sister chromatid junction formed after strand invasion. In conclusion, parental histone distribution at stressed forks regulates HR and provides a potential mechanism for the choice between HR and TLS that would depend on whether DNA synthesis is blocked at the lagging or the leading strand." @default.
- W4226323511 created "2022-05-05" @default.
- W4226323511 creator A5018476104 @default.
- W4226323511 creator A5029031372 @default.
- W4226323511 date "2022-04-05" @default.
- W4226323511 modified "2023-10-02" @default.
- W4226323511 title "Parental histone distribution at nascent strands controls homologous recombination during DNA damage tolerance" @default.
- W4226323511 cites W1560496206 @default.
- W4226323511 cites W1869411311 @default.
- W4226323511 cites W1936192069 @default.
- W4226323511 cites W1965011585 @default.
- W4226323511 cites W1965813899 @default.
- W4226323511 cites W1965818711 @default.
- W4226323511 cites W1965975821 @default.
- W4226323511 cites W1966072209 @default.
- W4226323511 cites W1984320346 @default.
- W4226323511 cites W1986258535 @default.
- W4226323511 cites W1989575399 @default.
- W4226323511 cites W2021074825 @default.
- W4226323511 cites W2024072532 @default.
- W4226323511 cites W2027065836 @default.
- W4226323511 cites W2032004743 @default.
- W4226323511 cites W2047820533 @default.
- W4226323511 cites W2049815581 @default.
- W4226323511 cites W2055776712 @default.
- W4226323511 cites W2055956764 @default.
- W4226323511 cites W2059788298 @default.
- W4226323511 cites W2067463001 @default.
- W4226323511 cites W2070910548 @default.
- W4226323511 cites W2071955851 @default.
- W4226323511 cites W2072295634 @default.
- W4226323511 cites W2074655992 @default.
- W4226323511 cites W2075387573 @default.
- W4226323511 cites W2079266876 @default.
- W4226323511 cites W2080574942 @default.
- W4226323511 cites W2083123225 @default.
- W4226323511 cites W2085866527 @default.
- W4226323511 cites W2086333179 @default.
- W4226323511 cites W2104584181 @default.
- W4226323511 cites W2107333316 @default.
- W4226323511 cites W2110285576 @default.
- W4226323511 cites W2111616806 @default.
- W4226323511 cites W2113051223 @default.
- W4226323511 cites W2113224775 @default.
- W4226323511 cites W2119247066 @default.
- W4226323511 cites W2119301405 @default.
- W4226323511 cites W2124915114 @default.
- W4226323511 cites W2125636072 @default.
- W4226323511 cites W2128387536 @default.
- W4226323511 cites W2143405836 @default.
- W4226323511 cites W2145269684 @default.
- W4226323511 cites W2151243552 @default.
- W4226323511 cites W2151533829 @default.
- W4226323511 cites W2156966442 @default.
- W4226323511 cites W2163938840 @default.
- W4226323511 cites W2170450010 @default.
- W4226323511 cites W2256210076 @default.
- W4226323511 cites W2262979968 @default.
- W4226323511 cites W2344657883 @default.
- W4226323511 cites W2582786552 @default.
- W4226323511 cites W2762190606 @default.
- W4226323511 cites W2886180522 @default.
- W4226323511 cites W2886311986 @default.
- W4226323511 cites W2889812869 @default.
- W4226323511 cites W2892569542 @default.
- W4226323511 cites W2901984000 @default.
- W4226323511 cites W2913385233 @default.
- W4226323511 cites W2972823446 @default.
- W4226323511 cites W2978575839 @default.
- W4226323511 cites W2992883457 @default.
- W4226323511 cites W3080687659 @default.
- W4226323511 cites W3172335938 @default.
- W4226323511 cites W3203093224 @default.
- W4226323511 cites W4210248006 @default.
- W4226323511 cites W4250813671 @default.
- W4226323511 doi "https://doi.org/10.1101/2022.04.05.487148" @default.
- W4226323511 hasPublicationYear "2022" @default.
- W4226323511 type Work @default.
- W4226323511 citedByCount "0" @default.
- W4226323511 crossrefType "posted-content" @default.
- W4226323511 hasAuthorship W4226323511A5018476104 @default.
- W4226323511 hasAuthorship W4226323511A5029031372 @default.
- W4226323511 hasBestOaLocation W42263235111 @default.
- W4226323511 hasConcept C102744134 @default.
- W4226323511 hasConcept C134935766 @default.
- W4226323511 hasConcept C143425029 @default.
- W4226323511 hasConcept C23458808 @default.
- W4226323511 hasConcept C2776630724 @default.
- W4226323511 hasConcept C2779012473 @default.
- W4226323511 hasConcept C54355233 @default.
- W4226323511 hasConcept C552990157 @default.
- W4226323511 hasConcept C60748783 @default.
- W4226323511 hasConcept C64927066 @default.
- W4226323511 hasConcept C73573662 @default.
- W4226323511 hasConcept C86803240 @default.
- W4226323511 hasConcept C95444343 @default.
- W4226323511 hasConceptScore W4226323511C102744134 @default.
- W4226323511 hasConceptScore W4226323511C134935766 @default.
- W4226323511 hasConceptScore W4226323511C143425029 @default.
- W4226323511 hasConceptScore W4226323511C23458808 @default.