Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226325411> ?p ?o ?g. }
- W4226325411 abstract "During cardiac development, endocardial cells (EdCs) produce growth factors to promote myocardial morphogenesis and growth. In particular, EdCs produce neuregulin which is required for ventricular cardiomyocytes (CMs) to seed the multicellular ridges known as trabeculae. Defects in neuregulin signaling, or in endocardial sprouting toward CMs, cause hypotrabeculation. However, the mechanisms underlying endocardial sprouting remain largely unknown. Here, we first show by live imaging in zebrafish embryos that EdCs interact with CMs via dynamic membrane protrusions. After touching CMs, these protrusions remain in close contact with their target despite the vigorous cardiac contractions. Loss of the CM-derived peptide Apelin, or of the Apelin receptor, which is expressed in EdCs, leads to reduced endocardial sprouting and hypotrabeculation. Mechanistically, neuregulin signaling requires endocardial protrusions to induce extracellular signal-regulated kinase (Erk) activity in CMs and trigger their delamination. Altogether, these data show that Apelin signaling-dependent endocardial protrusions modulate CM behavior during trabeculation." @default.
- W4226325411 created "2022-05-05" @default.
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- W4226325411 date "2022-02-28" @default.
- W4226325411 modified "2023-09-23" @default.
- W4226325411 title "Apelin signaling dependent endocardial protrusions promote cardiac trabeculation in zebrafish" @default.
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- W4226325411 doi "https://doi.org/10.7554/elife.73231" @default.
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