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- W4226325645 abstract "Human ether-a-go-go-related gene (hERG) channel plays an essential role in the repolarization of the cardiac action potential. Genetic mutations and some chemicals/drugs interfere with hERG channel activity, which may prolong the QT interval and potentially cause long QT syndrome. The FluxOR™ thallium flux assay performed in two cell lines, U2OS and HEK293, with stable hERG expression can be used to identify compounds that inhibit hERG channel activity. This chapter describes a cell-based hERG channel inhibition assay that has been optimized and performed in a 1536-well plate format. The homogeneous and robust assay can be used to identify compounds that inhibit hERG channel activity." @default.
- W4226325645 created "2022-05-05" @default.
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- W4226325645 date "2022-01-01" @default.
- W4226325645 modified "2023-10-03" @default.
- W4226325645 title "Cell-Based hERG Channel Inhibition Assay in High-Throughput Format" @default.
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- W4226325645 doi "https://doi.org/10.1007/978-1-0716-2213-1_3" @default.
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