FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226333731> ?p ?o ?g. }

• W4226333731 endingPage "261" @default.
• W4226333731 startingPage "255" @default.
• W4226333731 abstract "Introduction. High morbidity rates of diseases of the endocrine system and the existing features of drinking water pollution with organochlorine compounds (OCCs) make it necessary to study the mechanisms of the influence of low doses of organochlorine pesticides on public health. The purpose of the study is to study the features of the formation of non-carcinogenic risk in the population associated with exposure to OCCs in drinking water and endocrine disorders, using the example of 2,4-dichlorophenoxyacetic acid (2,4-D) under conditions of chronic oral exposure in small doses in the experiment. Materials and methods. According to the results of a comparative hygienic assessment of more than 10 thousand samples of drinking water from centralized water supply in 41 municipalities of the Orenburg region, a rural area with the highest content of OCCs and 2,4-D was identified. There was executed an analysis of the incidence of diseases of the endocrine system, digestive system and metabolic disorders (E00-E90) in the population. The experimental part of the work was carried out on 2 groups of Wistar rats: the 1st group was control, the 2nd group consumed water containing 2,4-DA (ammonium salt of 2,4-dichlorophenoxyacetic acid) at a concentration of 0.015 mg/l (0 .5 MPC). In the blood serum of animals, an analysis was made of the level of hormones: triiodothyronine (T3) and thyroid hormone (T4), testosterone and insulin, with an assessment of body weight and epididymal fat. Results. The observation area was established to be characterized by a high level of contamination of drinking water with OCCs and mainly with 2,4-D. Non-carcinogenic risk for the endocrine system (0.005), corresponding to an acceptable level, is significantly higher by 2-4 times (p < 0.05) for adults and children than in the comparison area. The primary incidence of diseases of the endocrine system, digestive system and metabolic disorders (E00-E90) in the observation area (34.88±5.9) is by 2 times higher than the average regional value and 6 times in the comparison area, which indicates the manifestation of disruptive properties 2,4-D and OCCs. The experiment showed that in animals of the experimental group, body weight on day 135 is 10% higher than the control one. An increase in the level of insulin in animals of the experimental group by 70% on day 45 and by 25% on days 90 and 135 of the experiment was established. In the experimental group, on the 45th, 90th and 135th days, the concentrations of T3 decreased by 22%, 5% and 6%, and T4 - by 13%, 12% and 38%, respectively. By the end of the experiment, the testosterone content in the experimental group was lower by 36%. Limitations. The limitations of the study are related to the transfer of the results of experimental data to the studied exposed population and the assessment of only OCCs and 2,4-dichlorophenoxyacetic acid (2,4-D) in drinking water without taking into account other environmental factors. Conclusion. The conducted study testifies to the manifestation of the disruptive properties of 2,4-D in an animal experiment, which is expressed by a violation of the mechanisms of metabolism regulation. The results of the experiment showed the intake of small doses (0.5 MPC) of 2,4-D into the body to have an obesogenic effect, manifested in a gain in total body weight and epididymal fat, accompanied by a decrease in the level of testosterone and thyroid hormones in the blood serum." @default.
• W4226333731 created "2022-05-05" @default.
• W4226333731 creator A5037694726 @default.
• W4226333731 creator A5043964632 @default.
• W4226333731 creator A5059603128 @default.
• W4226333731 creator A5085111593 @default.
• W4226333731 creator A5085142204 @default.
• W4226333731 date "2022-04-08" @default.
• W4226333731 modified "2023-10-02" @default.
• W4226333731 title "Hygienic assessment of the risk of development of metabolic disorders associated with pollution of drinking water with organic chlorinous compounds" @default.
• W4226333731 cites W1971434563 @default.
• W4226333731 cites W1978046815 @default.
• W4226333731 cites W1987686493 @default.
• W4226333731 cites W1998943825 @default.
• W4226333731 cites W2033115653 @default.
• W4226333731 cites W2039366588 @default.
• W4226333731 cites W2085378790 @default.
• W4226333731 cites W2087545338 @default.
• W4226333731 cites W2133461377 @default.
• W4226333731 cites W2140321480 @default.
• W4226333731 cites W2509057624 @default.
• W4226333731 cites W2520757422 @default.
• W4226333731 cites W2535762306 @default.
• W4226333731 cites W2614814563 @default.
• W4226333731 cites W2990829178 @default.
• W4226333731 cites W2998435179 @default.
• W4226333731 cites W4239109204 @default.
• W4226333731 cites W4247527030 @default.
• W4226333731 doi "https://doi.org/10.47470/0016-9900-2022-101-3-255-261" @default.
• W4226333731 hasPublicationYear "2022" @default.
• W4226333731 type Work @default.
• W4226333731 citedByCount "0" @default.
• W4226333731 crossrefType "journal-article" @default.
• W4226333731 hasAuthorship W4226333731A5037694726 @default.
• W4226333731 hasAuthorship W4226333731A5043964632 @default.
• W4226333731 hasAuthorship W4226333731A5059603128 @default.
• W4226333731 hasAuthorship W4226333731A5085111593 @default.
• W4226333731 hasAuthorship W4226333731A5085142204 @default.
• W4226333731 hasConcept C134018914 @default.
• W4226333731 hasConcept C161176658 @default.
• W4226333731 hasConcept C185592680 @default.
• W4226333731 hasConcept C2908647359 @default.
• W4226333731 hasConcept C33070731 @default.
• W4226333731 hasConcept C42407357 @default.
• W4226333731 hasConcept C46699223 @default.
• W4226333731 hasConcept C526584372 @default.
• W4226333731 hasConcept C6557445 @default.
• W4226333731 hasConcept C71315377 @default.
• W4226333731 hasConcept C71924100 @default.
• W4226333731 hasConcept C86803240 @default.
• W4226333731 hasConcept C99454951 @default.
• W4226333731 hasConceptScore W4226333731C134018914 @default.
• W4226333731 hasConceptScore W4226333731C161176658 @default.
• W4226333731 hasConceptScore W4226333731C185592680 @default.
• W4226333731 hasConceptScore W4226333731C2908647359 @default.
• W4226333731 hasConceptScore W4226333731C33070731 @default.
• W4226333731 hasConceptScore W4226333731C42407357 @default.
• W4226333731 hasConceptScore W4226333731C46699223 @default.
• W4226333731 hasConceptScore W4226333731C526584372 @default.
• W4226333731 hasConceptScore W4226333731C6557445 @default.
• W4226333731 hasConceptScore W4226333731C71315377 @default.
• W4226333731 hasConceptScore W4226333731C71924100 @default.
• W4226333731 hasConceptScore W4226333731C86803240 @default.
• W4226333731 hasConceptScore W4226333731C99454951 @default.
• W4226333731 hasIssue "3" @default.
• W4226333731 hasLocation W42263337311 @default.
• W4226333731 hasOpenAccess W4226333731 @default.
• W4226333731 hasPrimaryLocation W42263337311 @default.
• W4226333731 hasRelatedWork W1990935649 @default.
• W4226333731 hasRelatedWork W2022236747 @default.
• W4226333731 hasRelatedWork W2405593176 @default.
• W4226333731 hasRelatedWork W2417281989 @default.
• W4226333731 hasRelatedWork W2462027381 @default.
• W4226333731 hasRelatedWork W2748952813 @default.
• W4226333731 hasRelatedWork W3032608546 @default.
• W4226333731 hasRelatedWork W4226402827 @default.
• W4226333731 hasRelatedWork W4281767619 @default.
• W4226333731 hasRelatedWork W2605482359 @default.
• W4226333731 hasVolume "101" @default.
• W4226333731 isParatext "false" @default.
• W4226333731 isRetracted "false" @default.
• W4226333731 workType "article" @default.