Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226336227> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W4226336227 endingPage "10" @default.
- W4226336227 startingPage "1" @default.
- W4226336227 abstract "Distinguishing between benign and malignant bile duct strictures has long been a diagnostic challenge in clinical practice.This study aimed to discover novel biomarkers in bile to improve the diagnostic accuracy of malignant biliary strictures.Bile samples were collected from 6 patients with malignant or benign biliary stricture, respectively. Protein profiles of the bile were analyzed with a semi-quantitative human antibody array of 440 proteins. Then the differential expressed proteins were screened by Venn diagram analysis. Following this, the accuracy of these potential biomarkers for discriminating between malignant and non-malignant biliary strictures was validated in a larger (n= 40) group of patients using ROC analysis and the best biomarker combination was further selected by lasso analysis.Twenty proteins were found differentially expressed in malignant versus benign biliary strictures, 6 of which were identified by Venn diagram analysis to be up-regulated regardless of the location of biliary strictures. Among the 6 biomarkers, bile lipocalin-2, P-cadherin, and adipsin showed better diagnostic utility than that of bile CA19-9. Lasso analysis identified that lipocalin-2, P-cadherin and CA19-9 as a group of makers best distinguished malignant from benign strictures.Lipocalin-2 and P-cadherin measurements in bile could be clinically useful for the detection of malignant biliary strictures." @default.
- W4226336227 created "2022-05-05" @default.
- W4226336227 creator A5010417032 @default.
- W4226336227 creator A5020568750 @default.
- W4226336227 creator A5028915613 @default.
- W4226336227 creator A5056194271 @default.
- W4226336227 creator A5078768332 @default.
- W4226336227 creator A5085809876 @default.
- W4226336227 date "2021-09-16" @default.
- W4226336227 modified "2023-09-27" @default.
- W4226336227 title "Antibody array-based proteomic screening of novel biomarkers in malignant biliary stricture" @default.
- W4226336227 cites W1270837331 @default.
- W4226336227 cites W1977009545 @default.
- W4226336227 cites W1985478991 @default.
- W4226336227 cites W1987419718 @default.
- W4226336227 cites W1992624964 @default.
- W4226336227 cites W2013710242 @default.
- W4226336227 cites W2044956035 @default.
- W4226336227 cites W2047361818 @default.
- W4226336227 cites W2077160928 @default.
- W4226336227 cites W2078089116 @default.
- W4226336227 cites W2086820350 @default.
- W4226336227 cites W2087650452 @default.
- W4226336227 cites W2128890961 @default.
- W4226336227 cites W2146846534 @default.
- W4226336227 cites W2159818270 @default.
- W4226336227 cites W2204289602 @default.
- W4226336227 cites W2474467836 @default.
- W4226336227 cites W2541964584 @default.
- W4226336227 cites W2566675531 @default.
- W4226336227 cites W2575395075 @default.
- W4226336227 cites W2575482178 @default.
- W4226336227 cites W2890614017 @default.
- W4226336227 cites W2982505370 @default.
- W4226336227 cites W2985194635 @default.
- W4226336227 cites W3001782841 @default.
- W4226336227 cites W4233305716 @default.
- W4226336227 doi "https://doi.org/10.3233/cbm-210095" @default.
- W4226336227 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34542063" @default.
- W4226336227 hasPublicationYear "2021" @default.
- W4226336227 type Work @default.
- W4226336227 citedByCount "0" @default.
- W4226336227 crossrefType "journal-article" @default.
- W4226336227 hasAuthorship W4226336227A5010417032 @default.
- W4226336227 hasAuthorship W4226336227A5020568750 @default.
- W4226336227 hasAuthorship W4226336227A5028915613 @default.
- W4226336227 hasAuthorship W4226336227A5056194271 @default.
- W4226336227 hasAuthorship W4226336227A5078768332 @default.
- W4226336227 hasAuthorship W4226336227A5085809876 @default.
- W4226336227 hasConcept C126322002 @default.
- W4226336227 hasConcept C142724271 @default.
- W4226336227 hasConcept C159654299 @default.
- W4226336227 hasConcept C20299238 @default.
- W4226336227 hasConcept C203014093 @default.
- W4226336227 hasConcept C2779777945 @default.
- W4226336227 hasConcept C2780801072 @default.
- W4226336227 hasConcept C2781197716 @default.
- W4226336227 hasConcept C55493867 @default.
- W4226336227 hasConcept C71924100 @default.
- W4226336227 hasConcept C86803240 @default.
- W4226336227 hasConcept C90924648 @default.
- W4226336227 hasConceptScore W4226336227C126322002 @default.
- W4226336227 hasConceptScore W4226336227C142724271 @default.
- W4226336227 hasConceptScore W4226336227C159654299 @default.
- W4226336227 hasConceptScore W4226336227C20299238 @default.
- W4226336227 hasConceptScore W4226336227C203014093 @default.
- W4226336227 hasConceptScore W4226336227C2779777945 @default.
- W4226336227 hasConceptScore W4226336227C2780801072 @default.
- W4226336227 hasConceptScore W4226336227C2781197716 @default.
- W4226336227 hasConceptScore W4226336227C55493867 @default.
- W4226336227 hasConceptScore W4226336227C71924100 @default.
- W4226336227 hasConceptScore W4226336227C86803240 @default.
- W4226336227 hasConceptScore W4226336227C90924648 @default.
- W4226336227 hasLocation W42263362271 @default.
- W4226336227 hasLocation W42263362272 @default.
- W4226336227 hasOpenAccess W4226336227 @default.
- W4226336227 hasPrimaryLocation W42263362271 @default.
- W4226336227 hasRelatedWork W152493332 @default.
- W4226336227 hasRelatedWork W2117136125 @default.
- W4226336227 hasRelatedWork W2169710617 @default.
- W4226336227 hasRelatedWork W2373049717 @default.
- W4226336227 hasRelatedWork W2375422963 @default.
- W4226336227 hasRelatedWork W2386050689 @default.
- W4226336227 hasRelatedWork W2519777062 @default.
- W4226336227 hasRelatedWork W3031149353 @default.
- W4226336227 hasRelatedWork W3031205922 @default.
- W4226336227 hasRelatedWork W4226119378 @default.
- W4226336227 isParatext "false" @default.
- W4226336227 isRetracted "false" @default.
- W4226336227 workType "article" @default.