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- W4226341722 abstract "Hematopoietic stem cell transplantation (HSCT) is an accepted therapeutic modality for the treatment of malignant and nonmalignant disorders. The indications for allogeneic and autologous HSCT are shown. Most allogeneic transplants performed in patients <20 years old are for acute leukemias (43%) or nonmalignant indications (35%). Preparation, or “conditioning,” for HSCT involves the delivery of high-dose chemotherapy with or without radiation to ablate or reduce hematopoiesis and to provide sufficient immunosuppression to allow donor cell engraftment. Recent advances in graft manipulation and cell and gene therapy have markedly improved the approach, utility, and outcomes of HSCT and cell therapy." @default.
- W4226341722 created "2022-05-05" @default.
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- W4226341722 date "2022-01-01" @default.
- W4226341722 modified "2023-09-26" @default.
- W4226341722 title "Hematopoietic stem cell transplantation and cellular therapy" @default.
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- W4226341722 doi "https://doi.org/10.1016/b978-0-12-821671-2.00003-9" @default.
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