FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226351424> ?p ?o ?g. }

• W4226351424 endingPage "721" @default.
• W4226351424 startingPage "713" @default.
• W4226351424 abstract "Opioid stewardship programs combine clinical, regulatory, and educational interventions to minimize inappropriate opioid use and prescribing for orthopedic and spine surgery. Most evaluations of stewardship programs quantify effects on prescriber behavior, whereas patient-relevant outcomes have been relatively neglected. The authors evaluated the impact of an opioid stewardship program on perioperative opioid consumption, prescribing, and related clinical outcomes after multilevel lumbar fusion.The study was based on a retrospective, quasi-experimental, pretest-posttest design in 268 adult patients who underwent multilevel lumbar fusion in 2016 (preimplementation, n = 141) or 2019 (postimplementation, n = 127). The primary outcome was in-hospital opioid consumption (morphine equivalent dose [MED], mg). Secondary outcomes included numeric rating scale pain scores (0-10), length of stay (LOS), incidence of opioid-induced side effects (gastrointestinal, nausea/vomiting, respiratory, sedation, cognitive), and preoperative and discharge prescribing. Outcomes were measured continuously during the hospital admission. Differences in outcomes between the epochs were assessed in bivariable (Wilcoxon signed-rank or Fisher's exact tests) and multivariable (Wald's chi-square test) analyses.In bivariable analyses, there were significant decreases in preoperative opioid use (46% vs 28% of patients, p = 0.002), preoperative opioid prescribing (MED 30 mg [IQR 20-60 mg] vs 20 mg [IQR 11-39 mg], p = 0.003), in-hospital opioid consumption (MED 329 mg [IQR 188-575 mg] vs 199 mg [100-372 mg], p < 0.001), the incidence of any opioid-related side effect (62% vs 50%, p = 0.03), and discharge opioid prescribing (MED 90 mg [IQR 60-135 mg] vs 60 mg [IQR 45-80 mg], p < 0.0001) between 2016 and 2019. There were no significant differences in postanesthesia care unit pain scores (4 [IQR 3-6] vs 5 [IQR 3-6], p = 0.33), nursing floor pain scores (4 [IQR 3-5] vs 4 [IQR 3-5], p = 0.93), or total LOS (118 hours [IQR 81-173 hours] vs 103 hours [IQR 81-132 hours], p = 0.21). On multivariable analysis, the opioid stewardship program was significantly associated with decreased discharge prescribing (Wald's chi square = 9.45, effect size -52.4, 95% confidence interval [CI] -86 to -19.0, p = 0.002). The number of lumbar levels fused had the strongest effect on total opioid consumption during the hospital stay (Wald's chi square = 16.53, effect size = 539, 95% CI 279.1 to 799, p < 0.001), followed by preoperative opioid use (Wald's chi square = 44.04, effect size = 5, 95% CI 4 to 7, p < 0.001).A significant decrease in perioperative opioid prescribing, consumption, and opioid-related side effects was found after implementation of an opioid stewardship program. These gains were achieved without adverse effects on pain scores or LOS. These results suggest the major impact of opioid stewardship programs for spine surgery may be on changing prescriber behavior." @default.
• W4226351424 created "2022-05-05" @default.
• W4226351424 creator A5008638908 @default.
• W4226351424 creator A5009848989 @default.
• W4226351424 creator A5014581827 @default.
• W4226351424 creator A5025789706 @default.
• W4226351424 creator A5047646013 @default.
• W4226351424 creator A5078096304 @default.
• W4226351424 creator A5078364191 @default.
• W4226351424 creator A5083036340 @default.
• W4226351424 creator A5083616069 @default.
• W4226351424 creator A5085856308 @default.
• W4226351424 creator A5087128983 @default.
• W4226351424 date "2022-05-01" @default.
• W4226351424 modified "2023-10-14" @default.
• W4226351424 title "Effects of an opioid stewardship program on opioid consumption and related outcomes after multilevel lumbar spine fusion: a pre- and postimplementation analysis of 268 patients" @default.
• W4226351424 cites W1934921610 @default.
• W4226351424 cites W2765130845 @default.
• W4226351424 cites W2766102666 @default.
• W4226351424 cites W2767426681 @default.
• W4226351424 cites W2883111981 @default.
• W4226351424 cites W2883878302 @default.
• W4226351424 cites W2898025923 @default.
• W4226351424 cites W2905299859 @default.
• W4226351424 cites W2910891159 @default.
• W4226351424 cites W2912004861 @default.
• W4226351424 cites W2917311373 @default.
• W4226351424 cites W2937415624 @default.
• W4226351424 cites W2946856705 @default.
• W4226351424 cites W2966075262 @default.
• W4226351424 cites W3014983101 @default.
• W4226351424 cites W3026737690 @default.
• W4226351424 cites W3052660097 @default.
• W4226351424 cites W3091426294 @default.
• W4226351424 cites W3092207705 @default.
• W4226351424 cites W3113042494 @default.
• W4226351424 cites W3134283082 @default.
• W4226351424 cites W3139517418 @default.
• W4226351424 doi "https://doi.org/10.3171/2021.8.spine21599" @default.
• W4226351424 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34861648" @default.
• W4226351424 hasPublicationYear "2022" @default.
• W4226351424 type Work @default.
• W4226351424 citedByCount "1" @default.
• W4226351424 countsByYear W42263514242023 @default.
• W4226351424 crossrefType "journal-article" @default.
• W4226351424 hasAuthorship W4226351424A5008638908 @default.
• W4226351424 hasAuthorship W4226351424A5009848989 @default.
• W4226351424 hasAuthorship W4226351424A5014581827 @default.
• W4226351424 hasAuthorship W4226351424A5025789706 @default.
• W4226351424 hasAuthorship W4226351424A5047646013 @default.
• W4226351424 hasAuthorship W4226351424A5078096304 @default.
• W4226351424 hasAuthorship W4226351424A5078364191 @default.
• W4226351424 hasAuthorship W4226351424A5083036340 @default.
• W4226351424 hasAuthorship W4226351424A5083616069 @default.
• W4226351424 hasAuthorship W4226351424A5085856308 @default.
• W4226351424 hasAuthorship W4226351424A5087128983 @default.
• W4226351424 hasConcept C126322002 @default.
• W4226351424 hasConcept C170493617 @default.
• W4226351424 hasConcept C194828623 @default.
• W4226351424 hasConcept C2778767360 @default.
• W4226351424 hasConcept C2781063702 @default.
• W4226351424 hasConcept C31174226 @default.
• W4226351424 hasConcept C42219234 @default.
• W4226351424 hasConcept C71924100 @default.
• W4226351424 hasConceptScore W4226351424C126322002 @default.
• W4226351424 hasConceptScore W4226351424C170493617 @default.
• W4226351424 hasConceptScore W4226351424C194828623 @default.
• W4226351424 hasConceptScore W4226351424C2778767360 @default.
• W4226351424 hasConceptScore W4226351424C2781063702 @default.
• W4226351424 hasConceptScore W4226351424C31174226 @default.
• W4226351424 hasConceptScore W4226351424C42219234 @default.
• W4226351424 hasConceptScore W4226351424C71924100 @default.
• W4226351424 hasIssue "5" @default.
• W4226351424 hasLocation W42263514241 @default.
• W4226351424 hasLocation W42263514242 @default.
• W4226351424 hasOpenAccess W4226351424 @default.
• W4226351424 hasPrimaryLocation W42263514241 @default.
• W4226351424 hasRelatedWork W2063149177 @default.
• W4226351424 hasRelatedWork W2349210304 @default.
• W4226351424 hasRelatedWork W2354785620 @default.
• W4226351424 hasRelatedWork W2910038432 @default.
• W4226351424 hasRelatedWork W2979285456 @default.
• W4226351424 hasRelatedWork W3023529023 @default.
• W4226351424 hasRelatedWork W4283687696 @default.
• W4226351424 hasRelatedWork W4293690051 @default.
• W4226351424 hasRelatedWork W4322727718 @default.
• W4226351424 hasRelatedWork W4380422742 @default.
• W4226351424 hasVolume "36" @default.
• W4226351424 isParatext "false" @default.
• W4226351424 isRetracted "false" @default.
• W4226351424 workType "article" @default.