Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226354347> ?p ?o ?g. }
- W4226354347 abstract "Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that mainly affects women in their reproductive years. A complex interaction of environmental and genetic factors leads to the disruption of immune tolerance towards self, causing overt immune activation and production of autoantibodies that attack multiple organs. Kidney damage, termed lupus nephritis, is the leading cause of SLE-related morbidity and mortality. Autoantibodies are central to propagating lupus nephritis through forming immune complexes and triggering complements. Immunoglobulin G (IgG) potently activates complement; therefore, autoantibodies were mainly considered to be of the IgG isotype. However, studies revealed that over 50% of patients produce autoantibodies of the IgE isotype. IgE autoantibodies actively participate in disease pathogenesis as omalizumab treatment, a humanized anti-IgE monoclonal antibody, improved disease severity in an SLE clinical trial. IgE is a hallmark of T helper 2-associated immunity. Thus, T helper 2-associated immunity seems to play a pathogenic role in a subset of SLE patients. This review summarizes human and animal studies that illustrate type 2 immune responses involved during the pathology of SLE." @default.
- W4226354347 created "2022-05-05" @default.
- W4226354347 creator A5018682015 @default.
- W4226354347 creator A5057379040 @default.
- W4226354347 creator A5061864431 @default.
- W4226354347 date "2022-04-04" @default.
- W4226354347 modified "2023-10-05" @default.
- W4226354347 title "T Helper 2-Associated Immunity in the Pathogenesis of Systemic Lupus Erythematosus" @default.
- W4226354347 cites W1579269973 @default.
- W4226354347 cites W1646280195 @default.
- W4226354347 cites W1777024811 @default.
- W4226354347 cites W1863259474 @default.
- W4226354347 cites W1896868877 @default.
- W4226354347 cites W1946062498 @default.
- W4226354347 cites W1981024696 @default.
- W4226354347 cites W1987862439 @default.
- W4226354347 cites W2001468996 @default.
- W4226354347 cites W2002308862 @default.
- W4226354347 cites W2013683990 @default.
- W4226354347 cites W2014831828 @default.
- W4226354347 cites W2016844693 @default.
- W4226354347 cites W2022460432 @default.
- W4226354347 cites W2023237958 @default.
- W4226354347 cites W2029853233 @default.
- W4226354347 cites W2034314827 @default.
- W4226354347 cites W2041226615 @default.
- W4226354347 cites W2042606815 @default.
- W4226354347 cites W2049065673 @default.
- W4226354347 cites W2054582797 @default.
- W4226354347 cites W2055712900 @default.
- W4226354347 cites W2056775918 @default.
- W4226354347 cites W2081436744 @default.
- W4226354347 cites W2092047849 @default.
- W4226354347 cites W2093402128 @default.
- W4226354347 cites W2107871522 @default.
- W4226354347 cites W2116700955 @default.
- W4226354347 cites W2119517093 @default.
- W4226354347 cites W2128689914 @default.
- W4226354347 cites W2135276664 @default.
- W4226354347 cites W2155984096 @default.
- W4226354347 cites W2163739493 @default.
- W4226354347 cites W2167252574 @default.
- W4226354347 cites W2168043692 @default.
- W4226354347 cites W2169835116 @default.
- W4226354347 cites W2209665340 @default.
- W4226354347 cites W2216792268 @default.
- W4226354347 cites W2221985227 @default.
- W4226354347 cites W2268416727 @default.
- W4226354347 cites W2395115239 @default.
- W4226354347 cites W2461747480 @default.
- W4226354347 cites W2477823035 @default.
- W4226354347 cites W2521483984 @default.
- W4226354347 cites W2603432182 @default.
- W4226354347 cites W2607741101 @default.
- W4226354347 cites W2743180980 @default.
- W4226354347 cites W2761905894 @default.
- W4226354347 cites W2765641086 @default.
- W4226354347 cites W2793220769 @default.
- W4226354347 cites W2795629650 @default.
- W4226354347 cites W2800183196 @default.
- W4226354347 cites W2805490366 @default.
- W4226354347 cites W2883231926 @default.
- W4226354347 cites W2884684819 @default.
- W4226354347 cites W2903904789 @default.
- W4226354347 cites W2908503979 @default.
- W4226354347 cites W2917256218 @default.
- W4226354347 cites W2920788708 @default.
- W4226354347 cites W2939247829 @default.
- W4226354347 cites W2950897059 @default.
- W4226354347 cites W2983873775 @default.
- W4226354347 cites W3013505542 @default.
- W4226354347 cites W3015604504 @default.
- W4226354347 cites W3091847092 @default.
- W4226354347 cites W3199613124 @default.
- W4226354347 cites W3200769641 @default.
- W4226354347 cites W4210991698 @default.
- W4226354347 cites W4211168185 @default.
- W4226354347 cites W4292232933 @default.
- W4226354347 doi "https://doi.org/10.3389/fimmu.2022.866549" @default.
- W4226354347 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35444658" @default.
- W4226354347 hasPublicationYear "2022" @default.
- W4226354347 type Work @default.
- W4226354347 citedByCount "7" @default.
- W4226354347 countsByYear W42263543472022 @default.
- W4226354347 countsByYear W42263543472023 @default.
- W4226354347 crossrefType "journal-article" @default.
- W4226354347 hasAuthorship W4226354347A5018682015 @default.
- W4226354347 hasAuthorship W4226354347A5057379040 @default.
- W4226354347 hasAuthorship W4226354347A5061864431 @default.
- W4226354347 hasBestOaLocation W42263543471 @default.
- W4226354347 hasConcept C141105273 @default.
- W4226354347 hasConcept C142724271 @default.
- W4226354347 hasConcept C159654299 @default.
- W4226354347 hasConcept C163764329 @default.
- W4226354347 hasConcept C203014093 @default.
- W4226354347 hasConcept C2776912625 @default.
- W4226354347 hasConcept C2777991845 @default.
- W4226354347 hasConcept C2779134260 @default.
- W4226354347 hasConcept C2779912601 @default.
- W4226354347 hasConcept C2780942790 @default.