Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226357093> ?p ?o ?g. }
- W4226357093 endingPage "e253" @default.
- W4226357093 startingPage "e247" @default.
- W4226357093 abstract "Several studies have reported associations of proton pump inhibitor (PPI) treatment with the incidence of complications and even increased mortality in patients with liver cirrhosis. Up to now, there are no studies on the impact of PPI treatment in patients with hepatocellular carcinoma (HCC). Therefore, the aim of our study was to investigate the prognostic effects of PPI treatment in a cohort of patients with HCC treated by transarterial chemoembolization (TACE).Three hundred fifty-eight patients with HCC that received first-time TACE were included in a retrospective analysis. We explored effects of PPI treatment using uni- and multivariable regression models.One hundred sixty-seven of the 358 patients (46.6%) received PPI treatment. Median transplant-free survival after TACE was significantly lower in patients treated with PPIs compared to patients without PPI treatment [16.0 (10.7-21.3) months vs. 26 (22.2-29.8) months, P = 0.006]. Importantly, PPI treatment remained a significant prognostic factor for reduced survival after adjustment for patient demographics, tumor stadium and liver function [hazard ratio (HR) 1.40, 95% confidence interval (CI) 1.09-1.78, P = 0.005]. We observed a dose-dependent association of PPI treatment with survival: A higher daily PPI dose was an independent prognostic factor for reduced survival (HR 1.32, 95% CI 1.14-1.54, P < 0.001). Notably, 58.1% of patients receiving PPIs had no clear indication therefor.PPI treatment is associated with reduced survival in patients with HCC in a dose-dependent manner. Thus, indication for PPI treatment should be evaluated attentively in these patients. Further, prospective studies are needed to validate the findings of this study." @default.
- W4226357093 created "2022-05-05" @default.
- W4226357093 creator A5004140673 @default.
- W4226357093 creator A5047082841 @default.
- W4226357093 creator A5051344430 @default.
- W4226357093 creator A5054826514 @default.
- W4226357093 creator A5061467882 @default.
- W4226357093 creator A5072206821 @default.
- W4226357093 creator A5084521927 @default.
- W4226357093 date "2020-12-14" @default.
- W4226357093 modified "2023-10-14" @default.
- W4226357093 title "Proton pump inhibitor therapy is associated with reduced survival following first-time transarterial chemoembolization in patients with hepatocellular carcinoma" @default.
- W4226357093 cites W1939211773 @default.
- W4226357093 cites W1971357418 @default.
- W4226357093 cites W2005466328 @default.
- W4226357093 cites W2014116209 @default.
- W4226357093 cites W2035403644 @default.
- W4226357093 cites W2103567832 @default.
- W4226357093 cites W2116810060 @default.
- W4226357093 cites W2131439628 @default.
- W4226357093 cites W2133255569 @default.
- W4226357093 cites W2141515493 @default.
- W4226357093 cites W2153935627 @default.
- W4226357093 cites W2194591433 @default.
- W4226357093 cites W2277004004 @default.
- W4226357093 cites W2511041727 @default.
- W4226357093 cites W2520630780 @default.
- W4226357093 cites W2535014621 @default.
- W4226357093 cites W2605709490 @default.
- W4226357093 cites W2614302069 @default.
- W4226357093 cites W2761437180 @default.
- W4226357093 cites W2782782280 @default.
- W4226357093 cites W2801184429 @default.
- W4226357093 cites W2884019433 @default.
- W4226357093 cites W2886124161 @default.
- W4226357093 cites W2887109533 @default.
- W4226357093 cites W2921211225 @default.
- W4226357093 cites W2972264752 @default.
- W4226357093 cites W2995739910 @default.
- W4226357093 cites W4232620598 @default.
- W4226357093 cites W4239301040 @default.
- W4226357093 doi "https://doi.org/10.1097/meg.0000000000002018" @default.
- W4226357093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33323760" @default.
- W4226357093 hasPublicationYear "2020" @default.
- W4226357093 type Work @default.
- W4226357093 citedByCount "0" @default.
- W4226357093 crossrefType "journal-article" @default.
- W4226357093 hasAuthorship W4226357093A5004140673 @default.
- W4226357093 hasAuthorship W4226357093A5047082841 @default.
- W4226357093 hasAuthorship W4226357093A5051344430 @default.
- W4226357093 hasAuthorship W4226357093A5054826514 @default.
- W4226357093 hasAuthorship W4226357093A5061467882 @default.
- W4226357093 hasAuthorship W4226357093A5072206821 @default.
- W4226357093 hasAuthorship W4226357093A5084521927 @default.
- W4226357093 hasConcept C120665830 @default.
- W4226357093 hasConcept C121332964 @default.
- W4226357093 hasConcept C126322002 @default.
- W4226357093 hasConcept C167135981 @default.
- W4226357093 hasConcept C207103383 @default.
- W4226357093 hasConcept C2777214474 @default.
- W4226357093 hasConcept C2778019345 @default.
- W4226357093 hasConcept C2778455285 @default.
- W4226357093 hasConcept C2781025758 @default.
- W4226357093 hasConcept C2992208098 @default.
- W4226357093 hasConcept C44249647 @default.
- W4226357093 hasConcept C50382708 @default.
- W4226357093 hasConcept C61511704 @default.
- W4226357093 hasConcept C71924100 @default.
- W4226357093 hasConcept C90924648 @default.
- W4226357093 hasConceptScore W4226357093C120665830 @default.
- W4226357093 hasConceptScore W4226357093C121332964 @default.
- W4226357093 hasConceptScore W4226357093C126322002 @default.
- W4226357093 hasConceptScore W4226357093C167135981 @default.
- W4226357093 hasConceptScore W4226357093C207103383 @default.
- W4226357093 hasConceptScore W4226357093C2777214474 @default.
- W4226357093 hasConceptScore W4226357093C2778019345 @default.
- W4226357093 hasConceptScore W4226357093C2778455285 @default.
- W4226357093 hasConceptScore W4226357093C2781025758 @default.
- W4226357093 hasConceptScore W4226357093C2992208098 @default.
- W4226357093 hasConceptScore W4226357093C44249647 @default.
- W4226357093 hasConceptScore W4226357093C50382708 @default.
- W4226357093 hasConceptScore W4226357093C61511704 @default.
- W4226357093 hasConceptScore W4226357093C71924100 @default.
- W4226357093 hasConceptScore W4226357093C90924648 @default.
- W4226357093 hasIssue "1S" @default.
- W4226357093 hasLocation W42263570931 @default.
- W4226357093 hasLocation W42263570932 @default.
- W4226357093 hasOpenAccess W4226357093 @default.
- W4226357093 hasPrimaryLocation W42263570931 @default.
- W4226357093 hasRelatedWork W1995827984 @default.
- W4226357093 hasRelatedWork W2266860383 @default.
- W4226357093 hasRelatedWork W2469494898 @default.
- W4226357093 hasRelatedWork W2766588635 @default.
- W4226357093 hasRelatedWork W3030449887 @default.
- W4226357093 hasRelatedWork W3032094436 @default.
- W4226357093 hasRelatedWork W325818975 @default.
- W4226357093 hasRelatedWork W4315477377 @default.
- W4226357093 hasRelatedWork W4384497977 @default.