Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226367057> ?p ?o ?g. }
- W4226367057 endingPage "426" @default.
- W4226367057 startingPage "408" @default.
- W4226367057 abstract "Type 2 diabetes (T2D) is a global health problem caused primarily due to the inability of pancreatic beta-cells to secrete adequate amounts of insulin during insulin resistance (IR). However, IR alone is not responsible for the development of T2D, rather gradual loss of beta-cell function in IR leads toward T2D. Impaired glucose-stimulated insulin secretion (GSIS) is responsible for beta-cell failure and one of the major causes of developing T2D in the presence of IR. The mechanisms underlying the progressive failure of beta-cells in insulin resistance-induced prolonged hyperglycemic conditions remain unresolved. The current study aimed to capture key factors responsible for the progression of diabetes in the IR condition. So, we proposed and analysed the GSIS process through a six-dimensional model incorporating calcium and ATP. We established our model by simulating both the normal and the insulin resistance-induced hyperglycemic conditions. Our analysis revealed the possible factors responsible for the impaired GSIS process in IR, whose dysfunction can lead to T2D. Finally, using the parameter recalibration analysis, we uncovered the potential therapeutic strategies for compensating the insulin secretion-reducing alterations that could eventually help prevent the disease progression." @default.
- W4226367057 created "2022-05-05" @default.
- W4226367057 creator A5028010967 @default.
- W4226367057 creator A5042960286 @default.
- W4226367057 creator A5082491317 @default.
- W4226367057 date "2022-08-01" @default.
- W4226367057 modified "2023-10-16" @default.
- W4226367057 title "A minimal model of glucose-stimulated insulin secretion process explores factors responsible for the development of type 2 diabetes" @default.
- W4226367057 cites W1012070930 @default.
- W4226367057 cites W1500581425 @default.
- W4226367057 cites W1532891073 @default.
- W4226367057 cites W171885414 @default.
- W4226367057 cites W1789878029 @default.
- W4226367057 cites W1866455211 @default.
- W4226367057 cites W1908872058 @default.
- W4226367057 cites W1932740246 @default.
- W4226367057 cites W1970896932 @default.
- W4226367057 cites W1975007709 @default.
- W4226367057 cites W1975024023 @default.
- W4226367057 cites W1975588287 @default.
- W4226367057 cites W1977274289 @default.
- W4226367057 cites W1978062520 @default.
- W4226367057 cites W1980894737 @default.
- W4226367057 cites W1981547910 @default.
- W4226367057 cites W1984817899 @default.
- W4226367057 cites W1986436191 @default.
- W4226367057 cites W1989817905 @default.
- W4226367057 cites W1993414114 @default.
- W4226367057 cites W1995174276 @default.
- W4226367057 cites W1998666012 @default.
- W4226367057 cites W2000020837 @default.
- W4226367057 cites W2000569688 @default.
- W4226367057 cites W2008986362 @default.
- W4226367057 cites W2015256748 @default.
- W4226367057 cites W2032840033 @default.
- W4226367057 cites W2033763256 @default.
- W4226367057 cites W2038212378 @default.
- W4226367057 cites W2045328306 @default.
- W4226367057 cites W2047038614 @default.
- W4226367057 cites W2049016439 @default.
- W4226367057 cites W2049131219 @default.
- W4226367057 cites W2050051162 @default.
- W4226367057 cites W2052524549 @default.
- W4226367057 cites W2055791664 @default.
- W4226367057 cites W2058342085 @default.
- W4226367057 cites W2059576421 @default.
- W4226367057 cites W2062573090 @default.
- W4226367057 cites W2065011201 @default.
- W4226367057 cites W2067096633 @default.
- W4226367057 cites W2072320376 @default.
- W4226367057 cites W2074014927 @default.
- W4226367057 cites W2075353339 @default.
- W4226367057 cites W2075603869 @default.
- W4226367057 cites W2076794464 @default.
- W4226367057 cites W2083850806 @default.
- W4226367057 cites W2085490648 @default.
- W4226367057 cites W2099719924 @default.
- W4226367057 cites W2101870887 @default.
- W4226367057 cites W2110482601 @default.
- W4226367057 cites W2112573165 @default.
- W4226367057 cites W2112654061 @default.
- W4226367057 cites W2120965964 @default.
- W4226367057 cites W2121452195 @default.
- W4226367057 cites W2122220050 @default.
- W4226367057 cites W2125853346 @default.
- W4226367057 cites W2133222023 @default.
- W4226367057 cites W2134303784 @default.
- W4226367057 cites W2145413187 @default.
- W4226367057 cites W2147284000 @default.
- W4226367057 cites W2149895222 @default.
- W4226367057 cites W2149943414 @default.
- W4226367057 cites W2151316409 @default.
- W4226367057 cites W2151771133 @default.
- W4226367057 cites W2152637004 @default.
- W4226367057 cites W2154527769 @default.
- W4226367057 cites W2155126124 @default.
- W4226367057 cites W2156382517 @default.
- W4226367057 cites W2159859567 @default.
- W4226367057 cites W2160873546 @default.
- W4226367057 cites W2166009190 @default.
- W4226367057 cites W2176847545 @default.
- W4226367057 cites W2272494750 @default.
- W4226367057 cites W2273325308 @default.
- W4226367057 cites W2335980015 @default.
- W4226367057 cites W2407236892 @default.
- W4226367057 cites W2543536036 @default.
- W4226367057 cites W2592545469 @default.
- W4226367057 cites W2739746122 @default.
- W4226367057 cites W2772619423 @default.
- W4226367057 cites W2791399608 @default.
- W4226367057 cites W2804155759 @default.
- W4226367057 cites W2894698210 @default.
- W4226367057 cites W3015880044 @default.
- W4226367057 cites W3106610573 @default.
- W4226367057 cites W3112780134 @default.
- W4226367057 cites W3135428162 @default.
- W4226367057 cites W4214772579 @default.
- W4226367057 doi "https://doi.org/10.1016/j.apm.2022.03.035" @default.