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- W4226375328 abstract "Short-term and long-term steroid contraceptive systems are widely employed in adolescents and premenopausal women; they could induce variation in bone metabolism, but whether these changes increase the overall fracture risk is not yet clear.A systematic search of scientific publications about hormonal contraceptives and bone metabolism in reproductive age women was conducted.In adolescent girl, combined oral contraceptives could have a deleterious effect on bone health when their onset is within three years after menarche and when they contain ethinyl estradiol at the dose of 20 mcg. In perimenopausal women, steroid contraceptives seem not influence bone health nor increase osteoporotic fractures risk in menopause. The oral progestogens intake is not related to negative effects on skeletal health. Depot medroxyprogesterone acetate (DMPA) induce a prolonged hypoestrogenism with secondary detrimental effect on healthy bone; the higher bone loss was observed at the DMPA dose of 150 mg intramuscular such as after long-term DMPA-users. Progestin-based implants and intrauterine devices have not negative effect on bone health.Since sex-steroid drugs induce variations in hormonal circulating concentrations, they may negatively affect bone metabolism. Contraceptive choice should be tailored evaluating any possible effect on bone health. Clinicians should always perform a precontraceptive counselling to identify any coexisting condition that may affect bone health. Further randomized studies are needed to confirm these results." @default.
- W4226375328 created "2022-05-05" @default.
- W4226375328 creator A5024264483 @default.
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- W4226375328 creator A5062537865 @default.
- W4226375328 creator A5068888346 @default.
- W4226375328 creator A5084635250 @default.
- W4226375328 date "2021-12-01" @default.
- W4226375328 modified "2023-09-26" @default.
- W4226375328 title "Bone health and hormonal contraception" @default.
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