Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226380212> ?p ?o ?g. }
- W4226380212 endingPage "378" @default.
- W4226380212 startingPage "359" @default.
- W4226380212 abstract "Erenumab is a monoclonal antibody targeting the calcitonin gene-related peptide (CGRP) receptor suitable for episodic and chronic migraine prevention. Randomized clinical trials proved the superiority of erenumab to placebo in a strictly selected population, while real-world studies confirmed treatment efficacy in more severe forms of disease - most patients suffered from chronic migraine with medication overuse headache, had prior treatment failures, and long disease duration. According to guidelines, anti-CGRP pathway monoclonal antibodies should be reserved to patients who failed or have contraindication to several classes of preventive treatments. However, their ease of use, tolerability and efficacy make these monoclonal antibodies ideally suitable for most patients with migraine; cost-effectiveness needs to be considered when looking at expanding current prescription criteria. Also, data from open label extensions of randomized control trials confirmed sustained benefits of prolonged treatment up to 5 consecutive years without significant risk of adverse events. Further studies will provide insights on optimal treatment duration to achieve migraine remission and predictors of treatment response. In the present work, we aimed at reviewing design and results of the main studies on erenumab and discussing treatment use in the current migraine prevention scenario; we also summarized the main ongoing research projects and provided clinical perspectives for the future." @default.
- W4226380212 created "2022-05-05" @default.
- W4226380212 creator A5052696387 @default.
- W4226380212 creator A5054471791 @default.
- W4226380212 creator A5069942848 @default.
- W4226380212 date "2022-04-01" @default.
- W4226380212 modified "2023-10-14" @default.
- W4226380212 title "Migraine Prevention with Erenumab: Focus on Patient Selection, Perspectives and Outcomes" @default.
- W4226380212 cites W2016045274 @default.
- W4226380212 cites W2268603990 @default.
- W4226380212 cites W2283260670 @default.
- W4226380212 cites W2463900009 @default.
- W4226380212 cites W2586533881 @default.
- W4226380212 cites W2608751463 @default.
- W4226380212 cites W2767625657 @default.
- W4226380212 cites W2770965214 @default.
- W4226380212 cites W2772237173 @default.
- W4226380212 cites W2792811290 @default.
- W4226380212 cites W2801341258 @default.
- W4226380212 cites W2811448052 @default.
- W4226380212 cites W2880621648 @default.
- W4226380212 cites W2888026698 @default.
- W4226380212 cites W2895070640 @default.
- W4226380212 cites W2898072840 @default.
- W4226380212 cites W2922174162 @default.
- W4226380212 cites W2923815971 @default.
- W4226380212 cites W2931089457 @default.
- W4226380212 cites W2935951435 @default.
- W4226380212 cites W2935967254 @default.
- W4226380212 cites W2939449854 @default.
- W4226380212 cites W2947416170 @default.
- W4226380212 cites W2947926919 @default.
- W4226380212 cites W2948901586 @default.
- W4226380212 cites W2956328323 @default.
- W4226380212 cites W2956772508 @default.
- W4226380212 cites W2963228596 @default.
- W4226380212 cites W2977140154 @default.
- W4226380212 cites W2979890929 @default.
- W4226380212 cites W2980838981 @default.
- W4226380212 cites W2980865543 @default.
- W4226380212 cites W2982541883 @default.
- W4226380212 cites W2994814664 @default.
- W4226380212 cites W2996109380 @default.
- W4226380212 cites W2998554460 @default.
- W4226380212 cites W2999319162 @default.
- W4226380212 cites W3000581217 @default.
- W4226380212 cites W3013178006 @default.
- W4226380212 cites W3015052705 @default.
- W4226380212 cites W3021146107 @default.
- W4226380212 cites W3027816440 @default.
- W4226380212 cites W3029690557 @default.
- W4226380212 cites W3030140473 @default.
- W4226380212 cites W3033647323 @default.
- W4226380212 cites W3033768524 @default.
- W4226380212 cites W3035231691 @default.
- W4226380212 cites W3036323806 @default.
- W4226380212 cites W3037111965 @default.
- W4226380212 cites W3039729714 @default.
- W4226380212 cites W3041421066 @default.
- W4226380212 cites W3047488603 @default.
- W4226380212 cites W3049036935 @default.
- W4226380212 cites W3049501725 @default.
- W4226380212 cites W3049682323 @default.
- W4226380212 cites W3049729762 @default.
- W4226380212 cites W3081075517 @default.
- W4226380212 cites W3081203772 @default.
- W4226380212 cites W3082316309 @default.
- W4226380212 cites W3082779878 @default.
- W4226380212 cites W3084499749 @default.
- W4226380212 cites W3085528651 @default.
- W4226380212 cites W3089824931 @default.
- W4226380212 cites W3091396307 @default.
- W4226380212 cites W3096991256 @default.
- W4226380212 cites W3106410706 @default.
- W4226380212 cites W3109562583 @default.
- W4226380212 cites W3115361485 @default.
- W4226380212 cites W3119747395 @default.
- W4226380212 cites W3120003085 @default.
- W4226380212 cites W3120635632 @default.
- W4226380212 cites W3120929599 @default.
- W4226380212 cites W3126007787 @default.
- W4226380212 cites W3127208638 @default.
- W4226380212 cites W3128770792 @default.
- W4226380212 cites W3131571567 @default.
- W4226380212 cites W3139399540 @default.
- W4226380212 cites W3144543283 @default.
- W4226380212 cites W3154170915 @default.
- W4226380212 cites W3159864859 @default.
- W4226380212 cites W3162640449 @default.
- W4226380212 cites W3180531776 @default.
- W4226380212 cites W3181707881 @default.
- W4226380212 cites W3183348330 @default.
- W4226380212 cites W3185049798 @default.
- W4226380212 cites W3195209130 @default.
- W4226380212 cites W3195381113 @default.
- W4226380212 cites W3195859227 @default.
- W4226380212 cites W3198432172 @default.
- W4226380212 cites W3198970595 @default.