Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226397832> ?p ?o ?g. }
- W4226397832 abstract "Metabolic inhibitors have been used in oncology for decades, dating back to antimetabolites developed in the 1940s. In the past 25 years, there has been increased recognition of metabolic derangements in tumor cells leading to a resurgence of interest in targeting metabolism. More recently there has been recognition that drugs targeting tumor metabolism also affect the often acidic, hypoxic, immunosuppressive tumor microenvironment (TME) and non-tumor cell populations within it, including immune cells. Here we review small-molecule metabolic inhibitors currently in clinical development for oncology applications. For each agent, we evaluate the preclinical studies demonstrating antitumor and TME effects and review ongoing clinical trials. The goal of this Review is to provide an overview of the landscape of metabolic inhibitors in clinical development for oncology." @default.
- W4226397832 created "2022-05-05" @default.
- W4226397832 creator A5017074842 @default.
- W4226397832 creator A5023686004 @default.
- W4226397832 creator A5025858464 @default.
- W4226397832 creator A5045645746 @default.
- W4226397832 creator A5090359406 @default.
- W4226397832 date "2022-01-04" @default.
- W4226397832 modified "2023-10-11" @default.
- W4226397832 title "Clinical development of metabolic inhibitors for oncology" @default.
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