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- W4226415237 abstract "Abstract Background: Migraine and epilepsy are comorbid diseases. Although they are independent clinical entities, we experienced a case of migraine complicated with epilepsy that exhibited unique temporary changes in clinical manifestation. Case presentation: A 29-year-old woman previously diagnosed with both migraine with aura and epilepsy visited our hospital complaining of unusual headaches. In her 20’s, the prodromal symptoms changed from typical scintillating scotoma lasting 20 minutes to moving lights against deja-vu scenery lasting 1-2 minutes. Then, loss of consciousness and urinary incontinence after headaches began to occur. Even generalized convulsion occurred. Considering the clinical symptoms, her headache was thought to be changed from migraine with typical aura to headache attributed to epileptic seizure. Administration of lomerizine hydrochloride decreased her headache attacks, urinary incontinence and loss of consciousness, and seizure. Conclusions: We report a patient with migraine and epilepsy who was successfully treated with lomerizine hydrochloride, an analog of flunarizine hydrochloride widely used in Japan. There may be mutual crosstalk between migraine and epilepsy. Lomerizine hydrochloride may have the efficacy of alleviating migraine and epilepsy." @default.
- W4226415237 created "2022-05-05" @default.
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- W4226415237 date "2022-04-08" @default.
- W4226415237 modified "2023-09-24" @default.
- W4226415237 title "Pathophysiological crosstalk between migraine aura and epilepsy: Effect of lomerizine hydrochloride" @default.
- W4226415237 doi "https://doi.org/10.21203/rs.3.rs-1525195/v1" @default.
- W4226415237 hasPublicationYear "2022" @default.
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