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- W4226419836 abstract "The prevention, early discovery and effective treatment of patients with hepatocellular carcinoma (HCC) remain a global medical challenge. At present, HCC is still mainly treated by surgery, supplemented by vascular embolization, radio frequency, radiotherapy, chemotherapy and biotherapy. The application of multikinase inhibitor sorafenib, chimeric antigen receptor T cells, or PD-1/PD-L1 inhibitors can prolong the median survival of HCC patients. However, the treatment efficacy is still unsatisfactory due to HCC metastasis and postoperative recurrence. During the process of hepatocyte malignant transformation, HCC tissues can express and secrete many types of specific biomarkers, or oncogenic antigen molecules into blood, for example, alpha-fetoprotein, glypican-3, Wnt3a (one of the key signaling molecules in the Wnt/β-catenin pathway), insulin-like growth factor (IGF)-II or IGF-I receptor, vascular endothelial growth factor, secretory clusterin and so on. In addition, combining immunotherapy with non-coding RNAs might improve anti-cancer efficacy. These biomarkers not only contribute to HCC diagnosis or prognosis, but may also become molecular targets for HCC therapy under developing or clinical trials. This article reviews the progress in emerging biomarkers in basic research or clinical trials for HCC immunotherapy." @default.
- W4226419836 created "2022-05-05" @default.
- W4226419836 creator A5007873838 @default.
- W4226419836 creator A5012278873 @default.
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- W4226419836 creator A5040558103 @default.
- W4226419836 creator A5047739125 @default.
- W4226419836 creator A5061461560 @default.
- W4226419836 date "2022-04-16" @default.
- W4226419836 modified "2023-09-22" @default.
- W4226419836 title "Encouraging specific biomarkers-based therapeutic strategies for hepatocellular carcinoma" @default.
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