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- W4226434756 abstract "Histones, ubiquitous in eukaryotes as DNA-packing proteins, find their evolutionary origins in archaea. Unlike the characterized histone proteins of a number of methanogenic and themophilic archaea, previous research indicated that HpyA, the sole histone encoded in the model halophile Halobacterium salinarum, is not involved in DNA packaging. Instead, it was found to have widespread but subtle effects on gene expression and to maintain wild type cell morphology. However, the precise function of halophilic histone-like proteins remain unclear. Here we use quantitative phenotyping, genetics, and functional genomics to investigate HpyA function. These experiments revealed that HpyA is important for growth and rod-shaped morphology in reduced salinity. HpyA preferentially binds DNA at discrete genomic sites under low salt to regulate expression of ion uptake, particularly iron. HpyA also globally but indirectly activates other ion uptake and nucleotide biosynthesis pathways in a salt-dependent manner. Taken together, these results demonstrate an alternative function for an archaeal histone-like protein as a transcriptional regulator, with its function tuned to the physiological stressors of the hypersaline environment." @default.
- W4226434756 created "2022-05-05" @default.
- W4226434756 creator A5055234524 @default.
- W4226434756 creator A5076394173 @default.
- W4226434756 date "2021-12-09" @default.
- W4226434756 modified "2023-10-18" @default.
- W4226434756 title "An archaeal histone-like protein regulates gene expression in response to salt stress" @default.
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- W4226434756 doi "https://doi.org/10.1093/nar/gkab1175" @default.
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