Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226437041> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W4226437041 endingPage "269" @default.
- W4226437041 startingPage "3" @default.
- W4226437041 abstract "Phosphatidylinostiol-trisphosphate (PIP3) is involved in the formation of lamellipodium during cell migration. PI3K is activated by multiple signaling pathways through GPCRs and RTKs, and it is responsible for phosphorylation of PIP2 to PIP3 which is the activation site for AKT and PDK. VPAC2, also known as VIPR2, is a secretin family GPCR that binds two homologous neuropeptides with high affinity, vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP). We previously found that VIP increased migration of cancer cells, but the underlying mechanism remains unclear. Here we investigated the involvement of the PI3K pathway in VIP-induced cell migration. In HeLa cells overexpressing VPAC2, VPAC2 was abundantly localized to lamellipodia in the presence of VIP, and PIP3 levels on the plasma membrane were increased. Conversely, VPAC2-silencing reduced VIP-induced increase in PIP3 levels on the plasma membrane. Silencing of VPAC2 in MCF-7 cells inhibited VIP-induced cell migration. In contrast, MCF-7 cells stably expressing VPAC2 exhibited the increased lamellipodium extension and cell migration in vitro and in vivo. These findings suggest that VIP promotes cancer cell migration by enhancing PIP3 synthesis through activation of VPAC2 receptors." @default.
- W4226437041 created "2022-05-05" @default.
- W4226437041 creator A5003799324 @default.
- W4226437041 creator A5005855723 @default.
- W4226437041 creator A5027301316 @default.
- W4226437041 creator A5036430010 @default.
- W4226437041 creator A5066094491 @default.
- W4226437041 creator A5070100060 @default.
- W4226437041 creator A5083316968 @default.
- W4226437041 creator A5090160123 @default.
- W4226437041 date "2022-01-01" @default.
- W4226437041 modified "2023-09-25" @default.
- W4226437041 title "A neuropeptide VIP induces cell migration by activating the PI3K pathway via VPAC2 receptors" @default.
- W4226437041 doi "https://doi.org/10.1254/jpssuppl.95.0_3-p-269" @default.
- W4226437041 hasPublicationYear "2022" @default.
- W4226437041 type Work @default.
- W4226437041 citedByCount "0" @default.
- W4226437041 crossrefType "journal-article" @default.
- W4226437041 hasAuthorship W4226437041A5003799324 @default.
- W4226437041 hasAuthorship W4226437041A5005855723 @default.
- W4226437041 hasAuthorship W4226437041A5027301316 @default.
- W4226437041 hasAuthorship W4226437041A5036430010 @default.
- W4226437041 hasAuthorship W4226437041A5066094491 @default.
- W4226437041 hasAuthorship W4226437041A5070100060 @default.
- W4226437041 hasAuthorship W4226437041A5083316968 @default.
- W4226437041 hasAuthorship W4226437041A5090160123 @default.
- W4226437041 hasBestOaLocation W42264370411 @default.
- W4226437041 hasConcept C104317684 @default.
- W4226437041 hasConcept C109185818 @default.
- W4226437041 hasConcept C118303440 @default.
- W4226437041 hasConcept C119056186 @default.
- W4226437041 hasConcept C135285700 @default.
- W4226437041 hasConcept C137738243 @default.
- W4226437041 hasConcept C1491633281 @default.
- W4226437041 hasConcept C170493617 @default.
- W4226437041 hasConcept C185592680 @default.
- W4226437041 hasConcept C55493867 @default.
- W4226437041 hasConcept C62478195 @default.
- W4226437041 hasConcept C8330315 @default.
- W4226437041 hasConcept C86554907 @default.
- W4226437041 hasConcept C86803240 @default.
- W4226437041 hasConcept C95444343 @default.
- W4226437041 hasConceptScore W4226437041C104317684 @default.
- W4226437041 hasConceptScore W4226437041C109185818 @default.
- W4226437041 hasConceptScore W4226437041C118303440 @default.
- W4226437041 hasConceptScore W4226437041C119056186 @default.
- W4226437041 hasConceptScore W4226437041C135285700 @default.
- W4226437041 hasConceptScore W4226437041C137738243 @default.
- W4226437041 hasConceptScore W4226437041C1491633281 @default.
- W4226437041 hasConceptScore W4226437041C170493617 @default.
- W4226437041 hasConceptScore W4226437041C185592680 @default.
- W4226437041 hasConceptScore W4226437041C55493867 @default.
- W4226437041 hasConceptScore W4226437041C62478195 @default.
- W4226437041 hasConceptScore W4226437041C8330315 @default.
- W4226437041 hasConceptScore W4226437041C86554907 @default.
- W4226437041 hasConceptScore W4226437041C86803240 @default.
- W4226437041 hasConceptScore W4226437041C95444343 @default.
- W4226437041 hasIssue "0" @default.
- W4226437041 hasLocation W42264370411 @default.
- W4226437041 hasOpenAccess W4226437041 @default.
- W4226437041 hasPrimaryLocation W42264370411 @default.
- W4226437041 hasRelatedWork W1532211979 @default.
- W4226437041 hasRelatedWork W1976390933 @default.
- W4226437041 hasRelatedWork W1976651029 @default.
- W4226437041 hasRelatedWork W2009671568 @default.
- W4226437041 hasRelatedWork W2014580473 @default.
- W4226437041 hasRelatedWork W2552070563 @default.
- W4226437041 hasRelatedWork W2908857200 @default.
- W4226437041 hasRelatedWork W3021768657 @default.
- W4226437041 hasRelatedWork W4232720035 @default.
- W4226437041 hasRelatedWork W947289517 @default.
- W4226437041 hasVolume "95" @default.
- W4226437041 isParatext "false" @default.
- W4226437041 isRetracted "false" @default.
- W4226437041 workType "article" @default.