Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226446025> ?p ?o ?g. }
- W4226446025 endingPage "319" @default.
- W4226446025 startingPage "307" @default.
- W4226446025 abstract "Genetic factors play an important role in the development of type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS). However, few genetic association studies related to these disorders have been performed with Vietnamese subjects. In this study, the potential associations of ADIPOQ single nucleotide polymorphisms (SNPs) with T2DM and MetS in a Kinh Vietnamese population were investigated.A study with 768 subjects was conducted to examine the associations of four ADIPOQ SNPs (rs266729, rs1501299, rs3774261, and rs822393) primarily with T2DM and secondarily with MetS. The TaqMan SNP genotyping assay was used to determine genotypes from subjects' DNA samples.After statistical adjustment for age, sex, and body mass index, the ADIPOQ SNP rs266729 was found to be associated with increased risk of T2DM under multiple inheritance models: codominant (OR = 2.30, 95% CI = 1.16-4.58), recessive (OR = 2.17, 95% CI = 1.11-4.26), and log-additive (OR = 1.32, 95% CI = 1.02-1.70). However, rs1501299, rs3774261, and rs822393 were not associated with risk for T2DM. Additionally, rs266729, rs3774261, and rs822393 were statistically associated with MetS, while rs1501299 was not. Haplotype analysis showed a strong linkage disequilibrium between the SNP pairs rs266729/rs822393 and rs1501299/rs3774261, and the haplotype rs266729(G)/rs822393(T) was not statistically associated with MetS.The results show that rs266729 is a lead candidate SNP associated with increased risk of developing T2DM and MetS in a Kinh Vietnamese population, while rs3774261 is associated with MetS only. Further functional characterization is needed to uncover the mechanism underlying the potential genotype-phenotype associations." @default.
- W4226446025 created "2022-05-05" @default.
- W4226446025 creator A5000541572 @default.
- W4226446025 creator A5008944738 @default.
- W4226446025 creator A5016853136 @default.
- W4226446025 creator A5017531924 @default.
- W4226446025 creator A5018928418 @default.
- W4226446025 creator A5035756464 @default.
- W4226446025 creator A5049024556 @default.
- W4226446025 creator A5056852152 @default.
- W4226446025 creator A5058751055 @default.
- W4226446025 creator A5069751977 @default.
- W4226446025 creator A5090626844 @default.
- W4226446025 creator A5087285014 @default.
- W4226446025 date "2022-02-01" @default.
- W4226446025 modified "2023-10-16" @default.
- W4226446025 title "Association of ADIPOQ Single-Nucleotide Polymorphisms with the Two Clinical Phenotypes Type 2 Diabetes Mellitus and Metabolic Syndrome in a Kinh Vietnamese Population" @default.
- W4226446025 cites W1524321743 @default.
- W4226446025 cites W1587875569 @default.
- W4226446025 cites W1885872317 @default.
- W4226446025 cites W1930548203 @default.
- W4226446025 cites W1972163053 @default.
- W4226446025 cites W1984191109 @default.
- W4226446025 cites W1997883409 @default.
- W4226446025 cites W2012510513 @default.
- W4226446025 cites W2012673605 @default.
- W4226446025 cites W2026748641 @default.
- W4226446025 cites W2026777651 @default.
- W4226446025 cites W2031122764 @default.
- W4226446025 cites W2036638698 @default.
- W4226446025 cites W2038429516 @default.
- W4226446025 cites W2047758963 @default.
- W4226446025 cites W2055035696 @default.
- W4226446025 cites W2063180918 @default.
- W4226446025 cites W2064254619 @default.
- W4226446025 cites W2070129011 @default.
- W4226446025 cites W2070414264 @default.
- W4226446025 cites W2096893827 @default.
- W4226446025 cites W2102133185 @default.
- W4226446025 cites W2108173192 @default.
- W4226446025 cites W2134395128 @default.
- W4226446025 cites W2143104968 @default.
- W4226446025 cites W2147084771 @default.
- W4226446025 cites W2149822561 @default.
- W4226446025 cites W2153348418 @default.
- W4226446025 cites W2155723834 @default.
- W4226446025 cites W2160859576 @default.
- W4226446025 cites W2344529781 @default.
- W4226446025 cites W2510223787 @default.
- W4226446025 cites W2607031541 @default.
- W4226446025 cites W2747447219 @default.
- W4226446025 cites W2782018408 @default.
- W4226446025 cites W2791011305 @default.
- W4226446025 cites W2793435470 @default.
- W4226446025 cites W2800550239 @default.
- W4226446025 cites W2870439669 @default.
- W4226446025 cites W2883622734 @default.
- W4226446025 cites W2952013316 @default.
- W4226446025 cites W2975033883 @default.
- W4226446025 cites W2979827518 @default.
- W4226446025 cites W3006860480 @default.
- W4226446025 cites W3014708354 @default.
- W4226446025 cites W3022561961 @default.
- W4226446025 cites W3046481682 @default.
- W4226446025 cites W3084346878 @default.
- W4226446025 cites W3097170496 @default.
- W4226446025 cites W3107560846 @default.
- W4226446025 cites W3128373745 @default.
- W4226446025 cites W3130963455 @default.
- W4226446025 cites W3162064185 @default.
- W4226446025 cites W3165246454 @default.
- W4226446025 cites W3197811784 @default.
- W4226446025 cites W3209098971 @default.
- W4226446025 cites W3213095455 @default.
- W4226446025 cites W4235479662 @default.
- W4226446025 cites W4238251256 @default.
- W4226446025 cites W4238700990 @default.
- W4226446025 doi "https://doi.org/10.2147/dmso.s347830" @default.
- W4226446025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35140489" @default.
- W4226446025 hasPublicationYear "2022" @default.
- W4226446025 type Work @default.
- W4226446025 citedByCount "4" @default.
- W4226446025 countsByYear W42264460252022 @default.
- W4226446025 countsByYear W42264460252023 @default.
- W4226446025 crossrefType "journal-article" @default.
- W4226446025 hasAuthorship W4226446025A5000541572 @default.
- W4226446025 hasAuthorship W4226446025A5008944738 @default.
- W4226446025 hasAuthorship W4226446025A5016853136 @default.
- W4226446025 hasAuthorship W4226446025A5017531924 @default.
- W4226446025 hasAuthorship W4226446025A5018928418 @default.
- W4226446025 hasAuthorship W4226446025A5035756464 @default.
- W4226446025 hasAuthorship W4226446025A5049024556 @default.
- W4226446025 hasAuthorship W4226446025A5056852152 @default.
- W4226446025 hasAuthorship W4226446025A5058751055 @default.
- W4226446025 hasAuthorship W4226446025A5069751977 @default.
- W4226446025 hasAuthorship W4226446025A5087285014 @default.
- W4226446025 hasAuthorship W4226446025A5090626844 @default.
- W4226446025 hasBestOaLocation W42264460251 @default.