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- W4226453131 abstract "Gene therapy is an advanced treatment to cure many complex diseases and attained significant interest to stop the defective mutations at gene level. However, delivering the considerable concentration of right molecule to the desired cells or tissues and overcome multidrug resistance (MDR) are challenging tasks in gene therapy. To date, several viral and nonviral vectors for gene delivery systems have been developed and possess some serious unresolved concerns. Inorganic nanoparticles (NPs) have been used as potential alternative nonviral carriers for gene delivery systems with improved transfection efficiency. Among nonviral carriers, calcium (Ca2+) incorporated with inorganic anions (CO32− and PO43−) has promising advantages in terms of gene loading and biocompatibility. Particularly, CaCO3 is a natural mineral which is widely available in hard tissues and by varying the ratio of Ca/CO32−, DNA and drugs could be loaded with high encapsulation efficiency. Therefore, this chapter will discuss the synthesis of CaCO3-based nanocomposites with respect to gene delivery applications. This chapter beautifully elaborates the wide range of primary materials for the fabrication of CaCO3, coating substance for the functionalization, and various gene loading/unloading mechanisms under various factors for gene delivery with impactful discussion." @default.
- W4226453131 created "2022-05-05" @default.
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- W4226453131 date "2022-01-01" @default.
- W4226453131 modified "2023-09-27" @default.
- W4226453131 title "Calcium Carbonate-Based Nanoparticles for Gene Delivery" @default.
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- W4226453131 doi "https://doi.org/10.1007/978-981-16-5419-0_26" @default.
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