FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226455265> ?p ?o ?g. }

• W4226455265 endingPage "10" @default.
• W4226455265 startingPage "1" @default.
• W4226455265 abstract "Ureaplasma parvum is a commensal bacterium in the female reproductive tract but has been associated with pregnancy complications such as preterm prelabor rupture of membranes and preterm birth (PTB). However, the pathologic effects of U. parvum in the cervix, which prevents ascending infections during pregnancy, are still poorly understood. To determine the impact of U. parvum on the cervix, ectocervical (ecto) and endocervical (endo) epithelial and stromal cells were incubated with U. parvum. Macrophages were also tested as a proxy for cervical macrophages to determine the antigenicity of U. parvum. The effects of U. parvum, including influence on cell cycle and cell death, antimicrobial peptide (AMP) production, epithelial-to-mesenchymal transition (EMT), and inflammatory cytokine levels, were assessed. U. parvum colonized cervical epithelial and stromal cells 4 h post-infection. Like uninfected control, U. parvum neither inhibited cell cycle progression and nor caused cell death in cervical epithelial and stromal cells. U. parvum increased the production of the AMPs cathelicidin and human β-defensin 3 and exhibited weak signs of EMT evidenced by decreased cytokeratin 18 and increased vimentin expression in cervical epithelial cells. U. parvum induced a proinflammatory environment (cytokines) and increased MMP-9 in cervical epithelial cells but promoted pro- and anti-inflammatory response in cervical stromal cells and macrophages. U. parvum may colonize the cervical epithelial layer, but induction of AMPs and anti-inflammatory response may protect the cervix and may prevent ascending infections that can cause PTB. These findings suggest that U. parvum is a weak inducer of inflammation in the cervix." @default.
• W4226455265 created "2022-05-05" @default.
• W4226455265 creator A5011332945 @default.
• W4226455265 creator A5027079293 @default.
• W4226455265 creator A5027574364 @default.
• W4226455265 creator A5048431264 @default.
• W4226455265 creator A5051477656 @default.
• W4226455265 creator A5077662103 @default.
• W4226455265 date "2022-01-01" @default.
• W4226455265 modified "2023-10-11" @default.
• W4226455265 title "Inflammatory response elicited by Ureaplasma parvum colonization in human cervical epithelial, stromal, and immune cells" @default.
• W4226455265 cites W109833642 @default.
• W4226455265 cites W1566992315 @default.
• W4226455265 cites W1597453192 @default.
• W4226455265 cites W1754047185 @default.
• W4226455265 cites W1965814262 @default.
• W4226455265 cites W1973172245 @default.
• W4226455265 cites W1975755498 @default.
• W4226455265 cites W1980588968 @default.
• W4226455265 cites W1984513196 @default.
• W4226455265 cites W1990063572 @default.
• W4226455265 cites W1998713786 @default.
• W4226455265 cites W2014534199 @default.
• W4226455265 cites W2022161250 @default.
• W4226455265 cites W2022318593 @default.
• W4226455265 cites W2027763369 @default.
• W4226455265 cites W2030484762 @default.
• W4226455265 cites W2035903818 @default.
• W4226455265 cites W2040752427 @default.
• W4226455265 cites W2053430087 @default.
• W4226455265 cites W2056522368 @default.
• W4226455265 cites W2067240204 @default.
• W4226455265 cites W2073216175 @default.
• W4226455265 cites W2098536746 @default.
• W4226455265 cites W2111259873 @default.
• W4226455265 cites W2111678567 @default.
• W4226455265 cites W2117683486 @default.
• W4226455265 cites W2117875701 @default.
• W4226455265 cites W2127905656 @default.
• W4226455265 cites W2149077143 @default.
• W4226455265 cites W2149168973 @default.
• W4226455265 cites W2161074777 @default.
• W4226455265 cites W2170093908 @default.
• W4226455265 cites W2243724638 @default.
• W4226455265 cites W2281135803 @default.
• W4226455265 cites W2305973719 @default.
• W4226455265 cites W2551126071 @default.
• W4226455265 cites W2580044575 @default.
• W4226455265 cites W2750187331 @default.
• W4226455265 cites W2756593246 @default.
• W4226455265 cites W2768784613 @default.
• W4226455265 cites W2790902308 @default.
• W4226455265 cites W2793555588 @default.
• W4226455265 cites W2802110884 @default.
• W4226455265 cites W2912400756 @default.
• W4226455265 cites W2943913768 @default.
• W4226455265 cites W2952314454 @default.
• W4226455265 cites W2961632535 @default.
• W4226455265 cites W2999843267 @default.
• W4226455265 cites W3000138379 @default.
• W4226455265 cites W3009410572 @default.
• W4226455265 cites W3028435764 @default.
• W4226455265 cites W3036685747 @default.
• W4226455265 cites W3039933782 @default.
• W4226455265 cites W3044610191 @default.
• W4226455265 cites W3084304278 @default.
• W4226455265 cites W3094771245 @default.
• W4226455265 cites W3135335705 @default.
• W4226455265 cites W3137853063 @default.
• W4226455265 cites W3149242295 @default.
• W4226455265 cites W2014295664 @default.
• W4226455265 doi "https://doi.org/10.1530/rep-21-0308" @default.
• W4226455265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34780348" @default.
• W4226455265 hasPublicationYear "2022" @default.
• W4226455265 type Work @default.
• W4226455265 citedByCount "8" @default.
• W4226455265 countsByYear W42264552652022 @default.
• W4226455265 countsByYear W42264552652023 @default.
• W4226455265 crossrefType "journal-article" @default.
• W4226455265 hasAuthorship W4226455265A5011332945 @default.
• W4226455265 hasAuthorship W4226455265A5027079293 @default.
• W4226455265 hasAuthorship W4226455265A5027574364 @default.
• W4226455265 hasAuthorship W4226455265A5048431264 @default.
• W4226455265 hasAuthorship W4226455265A5051477656 @default.
• W4226455265 hasAuthorship W4226455265A5077662103 @default.
• W4226455265 hasBestOaLocation W42264552651 @default.
• W4226455265 hasConcept C121608353 @default.
• W4226455265 hasConcept C126322002 @default.
• W4226455265 hasConcept C164027704 @default.
• W4226455265 hasConcept C16930146 @default.
• W4226455265 hasConcept C203014093 @default.
• W4226455265 hasConcept C2776914184 @default.
• W4226455265 hasConcept C2777740455 @default.
• W4226455265 hasConcept C2778838687 @default.
• W4226455265 hasConcept C2909217659 @default.
• W4226455265 hasConcept C502942594 @default.
• W4226455265 hasConcept C71924100 @default.
• W4226455265 hasConcept C86803240 @default.

• next