Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226460534> ?p ?o ?g. }
- W4226460534 endingPage "1382" @default.
- W4226460534 startingPage "1364" @default.
- W4226460534 abstract "The recent discovery of the meningeal lymphatic vessels (mLVs) and glymphatic pathways has challenged the long-lasting dogma that the central nervous system (CNS) lacks a lymphatic system and therefore does not interact with peripheral immunity. This discovery has reshaped our understanding of mechanisms underlying CNS drainage. Under normal conditions, a close connection between mLVs and the glymphatic system enables metabolic waste removal, immune cell trafficking, and CNS immune surveillance. Dysfunction of the glymphatic-mLV system can lead to toxic protein accumulation in the brain, and it contributes to the development of a series of neurodegenerative disorders, such as Alzheimer's and Parkinson's diseases. The identification of precise cerebral transport routes is based mainly on indirect, invasive imaging of animals, and the results cannot always be applied to humans. Here we review the functions of the glymphatic-mLV system and evidence for its involvement in some CNS diseases. We focus on emerging noninvasive imaging techniques to evaluate the human glymphatic-mLV system and their potential for preclinical diagnosis and prevention of neurodegenerative diseases. Potential strategies that target the glymphatic-mLV system in order to treat and prevent neurological disorders are also discussed." @default.
- W4226460534 created "2022-05-05" @default.
- W4226460534 creator A5015472522 @default.
- W4226460534 creator A5019429833 @default.
- W4226460534 creator A5063568408 @default.
- W4226460534 creator A5064772362 @default.
- W4226460534 creator A5082563691 @default.
- W4226460534 creator A5089981213 @default.
- W4226460534 date "2022-04-28" @default.
- W4226460534 modified "2023-10-16" @default.
- W4226460534 title "The meningeal lymphatic vessels and the glymphatic system: Potential therapeutic targets in neurological disorders" @default.
- W4226460534 cites W1495656315 @default.
- W4226460534 cites W1588685142 @default.
- W4226460534 cites W1817666133 @default.
- W4226460534 cites W1828576284 @default.
- W4226460534 cites W1847115864 @default.
- W4226460534 cites W1893558031 @default.
- W4226460534 cites W1923535990 @default.
- W4226460534 cites W1971013644 @default.
- W4226460534 cites W1971125401 @default.
- W4226460534 cites W1985530741 @default.
- W4226460534 cites W1989513441 @default.
- W4226460534 cites W1991348431 @default.
- W4226460534 cites W2011991034 @default.
- W4226460534 cites W2024955728 @default.
- W4226460534 cites W2030827970 @default.
- W4226460534 cites W2037133552 @default.
- W4226460534 cites W2040733706 @default.
- W4226460534 cites W2040880670 @default.
- W4226460534 cites W2043291008 @default.
- W4226460534 cites W2053405269 @default.
- W4226460534 cites W2053537550 @default.
- W4226460534 cites W2059172895 @default.
- W4226460534 cites W2060306892 @default.
- W4226460534 cites W2067766876 @default.
- W4226460534 cites W2073312679 @default.
- W4226460534 cites W2076015301 @default.
- W4226460534 cites W2081061369 @default.
- W4226460534 cites W2094376677 @default.
- W4226460534 cites W2094785614 @default.
- W4226460534 cites W2100314515 @default.
- W4226460534 cites W2106495485 @default.
- W4226460534 cites W2115565454 @default.
- W4226460534 cites W2127716652 @default.
- W4226460534 cites W2152719134 @default.
- W4226460534 cites W2156144629 @default.
- W4226460534 cites W2163225965 @default.
- W4226460534 cites W2167183660 @default.
- W4226460534 cites W2233981766 @default.
- W4226460534 cites W2291424342 @default.
- W4226460534 cites W2314430530 @default.
- W4226460534 cites W2397118986 @default.
- W4226460534 cites W2399582540 @default.
- W4226460534 cites W2425370520 @default.
- W4226460534 cites W2469685265 @default.
- W4226460534 cites W2474038480 @default.
- W4226460534 cites W2480915756 @default.
- W4226460534 cites W2509605723 @default.
- W4226460534 cites W2529201238 @default.
- W4226460534 cites W2559691789 @default.
- W4226460534 cites W2560748808 @default.
- W4226460534 cites W2587079693 @default.
- W4226460534 cites W2588487507 @default.
- W4226460534 cites W2595214063 @default.
- W4226460534 cites W2600959588 @default.
- W4226460534 cites W2601770895 @default.
- W4226460534 cites W2614586381 @default.
- W4226460534 cites W2616546324 @default.
- W4226460534 cites W2742497781 @default.
- W4226460534 cites W2746870493 @default.
- W4226460534 cites W2747884879 @default.
- W4226460534 cites W2749371381 @default.
- W4226460534 cites W2750130602 @default.
- W4226460534 cites W2751474624 @default.
- W4226460534 cites W2752544632 @default.
- W4226460534 cites W2760285987 @default.
- W4226460534 cites W2760815599 @default.
- W4226460534 cites W2760852110 @default.
- W4226460534 cites W2766060569 @default.
- W4226460534 cites W2766411834 @default.
- W4226460534 cites W2767482362 @default.
- W4226460534 cites W2768030986 @default.
- W4226460534 cites W2770162527 @default.
- W4226460534 cites W2770462733 @default.
- W4226460534 cites W2772468670 @default.
- W4226460534 cites W2783180147 @default.
- W4226460534 cites W2789256660 @default.
- W4226460534 cites W2789376055 @default.
- W4226460534 cites W2795294714 @default.
- W4226460534 cites W2797347068 @default.
- W4226460534 cites W2800974699 @default.
- W4226460534 cites W2801110912 @default.
- W4226460534 cites W2809378439 @default.
- W4226460534 cites W2837320447 @default.
- W4226460534 cites W2883628966 @default.
- W4226460534 cites W2886166995 @default.
- W4226460534 cites W2890806217 @default.
- W4226460534 cites W2892318814 @default.