Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226463358> ?p ?o ?g. }
- W4226463358 abstract "In malignant airway epithelial cells, structural abnormalities were evident from the cytokeratin organization. To determine whether the cytokeratins themselves were responsible, an in vitro model for bronchogenic carcinoma, consisting of three highly malignant lines and three less tumorigenic lines, was studied. Cytokeratins were evaluated by two-dimensional polyacrylamide gel electrophoresis (2D-PAGE). When typical constraints on tumors were relieved by in vitro culture, lines showed profiles resembling normal, primary cells. The CK5/CK14 combination, characteristic of basal epithelial layers, was represented by CK6A/CK14. CK17 was invariably present, while CK5, CK7, CK8, CK19, and CK42 content varied. CK19 appeared to substitute for the rarely observed CK18. While lacking the common CK8/CK18 combination of hyperproliferative cells, an invasive, metastasizing line had CK6A/CK7 or CK8 with CK19 suggesting derivation similar to adenocarcinomas. Bands of CK19 and actin migrated to higher pI in tumorigenic and malignant lines than in normal cells. Ubiquitinated acidic cytokeratins with a low isoelectric point (pI) and high molecular weight (MW) showed no consistent differences in lines that differed in growth potential. Type II made up 49–52% of total cytokeratins in nonmalignant lines, whereas highly malignant lines showed lower levels. Posttranslational modifications were identified but could not explain the shortfall of basic cytokeratins." @default.
- W4226463358 created "2022-05-05" @default.
- W4226463358 creator A5086906978 @default.
- W4226463358 date "2022-09-28" @default.
- W4226463358 modified "2023-09-30" @default.
- W4226463358 title "Cytokeratins of Tumorigenic and Highly Malignant Respiratory Tract Epithelial Cells" @default.
- W4226463358 cites W133994482 @default.
- W4226463358 cites W1555874196 @default.
- W4226463358 cites W1606423922 @default.
- W4226463358 cites W1968261842 @default.
- W4226463358 cites W1979769606 @default.
- W4226463358 cites W1981443985 @default.
- W4226463358 cites W1994565320 @default.
- W4226463358 cites W1996003960 @default.
- W4226463358 cites W2000569630 @default.
- W4226463358 cites W2002553965 @default.
- W4226463358 cites W2014230003 @default.
- W4226463358 cites W2014476767 @default.
- W4226463358 cites W2016693266 @default.
- W4226463358 cites W2018951971 @default.
- W4226463358 cites W2019485800 @default.
- W4226463358 cites W2026441469 @default.
- W4226463358 cites W2031723036 @default.
- W4226463358 cites W2039881906 @default.
- W4226463358 cites W2055115454 @default.
- W4226463358 cites W2060261524 @default.
- W4226463358 cites W2067494910 @default.
- W4226463358 cites W2067746951 @default.
- W4226463358 cites W2073049453 @default.
- W4226463358 cites W2076225566 @default.
- W4226463358 cites W2085575427 @default.
- W4226463358 cites W2088925212 @default.
- W4226463358 cites W2089260335 @default.
- W4226463358 cites W2092447047 @default.
- W4226463358 cites W2095592568 @default.
- W4226463358 cites W2103671500 @default.
- W4226463358 cites W2104658004 @default.
- W4226463358 cites W2107295635 @default.
- W4226463358 cites W2113368077 @default.
- W4226463358 cites W2118379843 @default.
- W4226463358 cites W2119080552 @default.
- W4226463358 cites W2131450722 @default.
- W4226463358 cites W2134538612 @default.
- W4226463358 cites W2138688542 @default.
- W4226463358 cites W2147087309 @default.
- W4226463358 cites W2153364818 @default.
- W4226463358 cites W2160448497 @default.
- W4226463358 cites W2170486180 @default.
- W4226463358 cites W2286470180 @default.
- W4226463358 cites W2323694054 @default.
- W4226463358 cites W2469275705 @default.
- W4226463358 cites W2469289450 @default.
- W4226463358 cites W2546208091 @default.
- W4226463358 cites W2563380014 @default.
- W4226463358 cites W2649171395 @default.
- W4226463358 cites W2856361897 @default.
- W4226463358 cites W2896370220 @default.
- W4226463358 cites W2937373235 @default.
- W4226463358 cites W3006762344 @default.
- W4226463358 cites W3043334532 @default.
- W4226463358 cites W84060708 @default.
- W4226463358 doi "https://doi.org/10.5772/intechopen.102592" @default.
- W4226463358 hasPublicationYear "2022" @default.
- W4226463358 type Work @default.
- W4226463358 citedByCount "0" @default.
- W4226463358 crossrefType "book-chapter" @default.
- W4226463358 hasAuthorship W4226463358A5086906978 @default.
- W4226463358 hasBestOaLocation W42264633581 @default.
- W4226463358 hasConcept C142724271 @default.
- W4226463358 hasConcept C153911025 @default.
- W4226463358 hasConcept C181199279 @default.
- W4226463358 hasConcept C202751555 @default.
- W4226463358 hasConcept C203014093 @default.
- W4226463358 hasConcept C204232928 @default.
- W4226463358 hasConcept C2779012181 @default.
- W4226463358 hasConcept C50476208 @default.
- W4226463358 hasConcept C529295009 @default.
- W4226463358 hasConcept C54355233 @default.
- W4226463358 hasConcept C55493867 @default.
- W4226463358 hasConcept C71924100 @default.
- W4226463358 hasConcept C81241287 @default.
- W4226463358 hasConcept C81885089 @default.
- W4226463358 hasConcept C86803240 @default.
- W4226463358 hasConcept C96294017 @default.
- W4226463358 hasConceptScore W4226463358C142724271 @default.
- W4226463358 hasConceptScore W4226463358C153911025 @default.
- W4226463358 hasConceptScore W4226463358C181199279 @default.
- W4226463358 hasConceptScore W4226463358C202751555 @default.
- W4226463358 hasConceptScore W4226463358C203014093 @default.
- W4226463358 hasConceptScore W4226463358C204232928 @default.
- W4226463358 hasConceptScore W4226463358C2779012181 @default.
- W4226463358 hasConceptScore W4226463358C50476208 @default.
- W4226463358 hasConceptScore W4226463358C529295009 @default.
- W4226463358 hasConceptScore W4226463358C54355233 @default.
- W4226463358 hasConceptScore W4226463358C55493867 @default.
- W4226463358 hasConceptScore W4226463358C71924100 @default.
- W4226463358 hasConceptScore W4226463358C81241287 @default.
- W4226463358 hasConceptScore W4226463358C81885089 @default.
- W4226463358 hasConceptScore W4226463358C86803240 @default.
- W4226463358 hasConceptScore W4226463358C96294017 @default.