FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226475589> ?p ?o ?g. }

• W4226475589 endingPage "5691" @default.
• W4226475589 startingPage "5678" @default.
• W4226475589 abstract "Abstract Gemcitabine (GEM) resistance is a major challenge for chemotherapy of pancreatic cancer. Previous studies have reported on the role of long noncoding RNA (lncRNA) in tumorigenesis of pancreatic cancer, however, the involvement of lncRNA in the development of GEM resistance of pancreatic cancer remains unclear. In the present study, we demonstrated that the antisense RNA1 of HIF1α (HIF1A-AS1) was significantly elevated in the GEM-resistant pancreatic cancer cells. Gain- and lost-of-function experiments validated that HIF1A-AS1 promoted GEM resistance of pancreatic cancer cells both in vitro and vivo. We further revealed that HIF1A-AS1 upregulated HIF1α expression and thus promoted glycolysis to enhance GEM resistance of pancreatic cancer cells. Mechanistically, HIF1A-AS1 facilitated the interaction between serine/threonine kinase AKT and Y-box–binding protein 1 (YB1), which promoted phosphorylation of YB1 (pYB1). Meanwhile, HIF1A-AS1 recruited pYB1 to HIF1α mRNA that consequently promoted translation of HIF1α. Furthermore, HIF1α promoted HIF1A-AS1 transcription by directly binding to the HIF1α response element in the promoter area of HIF1A-AS1 to form a positive feedback. Consistently, both HIF1A-AS1 and HIF1α were upregulated in pancreatic cancer tissues and associated with poor overall survival. Together, our results underline a reciprocal loop of HIF1A-AS1 and HIF1α that contributes to GEM resistance of pancreatic cancer and indicate that HIF1A-AS1 might serve as a novel therapeutic target for GEM resistance of pancreatic cancer. Significance: These findings show that a reciprocal feedback of HIF1A-AS1 and HIF1α promotes gemcitabine resistance of pancreatic cancer, which provides an applicable therapeutic target." @default.
• W4226475589 created "2022-05-05" @default.
• W4226475589 creator A5004372852 @default.
• W4226475589 creator A5006411450 @default.
• W4226475589 creator A5006543483 @default.
• W4226475589 creator A5013793018 @default.
• W4226475589 creator A5016024429 @default.
• W4226475589 creator A5023510388 @default.
• W4226475589 creator A5038836690 @default.
• W4226475589 creator A5045082466 @default.
• W4226475589 creator A5050053929 @default.
• W4226475589 creator A5060868884 @default.
• W4226475589 creator A5071440898 @default.
• W4226475589 creator A5074753954 @default.
• W4226475589 creator A5076930880 @default.
• W4226475589 creator A5080506792 @default.
• W4226475589 creator A5085323494 @default.
• W4226475589 date "2021-09-30" @default.
• W4226475589 modified "2023-10-15" @default.
• W4226475589 title "LncRNA HIF1A-AS1 Promotes Gemcitabine Resistance of Pancreatic Cancer by Enhancing Glycolysis through Modulating the AKT/YB1/HIF1α Pathway" @default.
• W4226475589 cites W1895463703 @default.
• W4226475589 cites W1918281504 @default.
• W4226475589 cites W1968812902 @default.
• W4226475589 cites W2013793801 @default.
• W4226475589 cites W2017851659 @default.
• W4226475589 cites W2032183472 @default.
• W4226475589 cites W2040988771 @default.
• W4226475589 cites W2083452953 @default.
• W4226475589 cites W2101387096 @default.
• W4226475589 cites W2107318020 @default.
• W4226475589 cites W2108575282 @default.
• W4226475589 cites W2132349803 @default.
• W4226475589 cites W2143696174 @default.
• W4226475589 cites W2154317507 @default.
• W4226475589 cites W2158134441 @default.
• W4226475589 cites W2162547088 @default.
• W4226475589 cites W2165480504 @default.
• W4226475589 cites W2192943385 @default.
• W4226475589 cites W2245239316 @default.
• W4226475589 cites W2602017809 @default.
• W4226475589 cites W2605717729 @default.
• W4226475589 cites W2626481697 @default.
• W4226475589 cites W2792389397 @default.
• W4226475589 cites W2895390950 @default.
• W4226475589 cites W2902817477 @default.
• W4226475589 cites W2919642485 @default.
• W4226475589 cites W2936079648 @default.
• W4226475589 cites W2938814080 @default.
• W4226475589 cites W2964031629 @default.
• W4226475589 cites W2972626680 @default.
• W4226475589 cites W2985216317 @default.
• W4226475589 cites W3000246387 @default.
• W4226475589 cites W3010534550 @default.
• W4226475589 cites W3011183964 @default.
• W4226475589 cites W3011586576 @default.
• W4226475589 cites W3045960922 @default.
• W4226475589 cites W4210976084 @default.
• W4226475589 doi "https://doi.org/10.1158/0008-5472.can-21-0281" @default.
• W4226475589 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34593522" @default.
• W4226475589 hasPublicationYear "2021" @default.
• W4226475589 type Work @default.
• W4226475589 citedByCount "47" @default.
• W4226475589 countsByYear W42264755892021 @default.
• W4226475589 countsByYear W42264755892022 @default.
• W4226475589 countsByYear W42264755892023 @default.
• W4226475589 crossrefType "journal-article" @default.
• W4226475589 hasAuthorship W4226475589A5004372852 @default.
• W4226475589 hasAuthorship W4226475589A5006411450 @default.
• W4226475589 hasAuthorship W4226475589A5006543483 @default.
• W4226475589 hasAuthorship W4226475589A5013793018 @default.
• W4226475589 hasAuthorship W4226475589A5016024429 @default.
• W4226475589 hasAuthorship W4226475589A5023510388 @default.
• W4226475589 hasAuthorship W4226475589A5038836690 @default.
• W4226475589 hasAuthorship W4226475589A5045082466 @default.
• W4226475589 hasAuthorship W4226475589A5050053929 @default.
• W4226475589 hasAuthorship W4226475589A5060868884 @default.
• W4226475589 hasAuthorship W4226475589A5071440898 @default.
• W4226475589 hasAuthorship W4226475589A5074753954 @default.
• W4226475589 hasAuthorship W4226475589A5076930880 @default.
• W4226475589 hasAuthorship W4226475589A5080506792 @default.
• W4226475589 hasAuthorship W4226475589A5085323494 @default.
• W4226475589 hasBestOaLocation W42264755891 @default.
• W4226475589 hasConcept C121608353 @default.
• W4226475589 hasConcept C126322002 @default.
• W4226475589 hasConcept C143998085 @default.
• W4226475589 hasConcept C2780210213 @default.
• W4226475589 hasConcept C2780258809 @default.
• W4226475589 hasConcept C2780394083 @default.
• W4226475589 hasConcept C2781018059 @default.
• W4226475589 hasConcept C29537977 @default.
• W4226475589 hasConcept C31194975 @default.
• W4226475589 hasConcept C502942594 @default.
• W4226475589 hasConcept C555283112 @default.
• W4226475589 hasConcept C62478195 @default.
• W4226475589 hasConcept C71924100 @default.
• W4226475589 hasConcept C75217442 @default.
• W4226475589 hasConcept C86803240 @default.
• W4226475589 hasConcept C95444343 @default.

• next