FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226501911> ?p ?o ?g. }

• W4226501911 endingPage "e1010163" @default.
• W4226501911 startingPage "e1010163" @default.
• W4226501911 abstract "Arthropod-borne viruses infect both mosquito and mammalian hosts. While much is known about virus-host interactions that modulate viral gene expression in their mammalian host, much less is known about the interactions that involve inhibition, subversion or avoidance strategies in the mosquito host. A novel RNA-Protein interaction detection assay was used to detect proteins that directly or indirectly bind to dengue viral genomes in infected mosquito cells. Membrane-associated mosquito proteins Sec61A1 and Loquacious (Loqs) were found to be in complex with the viral RNA. Depletion analysis demonstrated that both Sec61A1 and Loqs have pro-viral functions in the dengue viral infectious cycle. Co-localization and pull-down assays showed that Loqs interacts with viral protein NS3 and both full-length and subgenomic viral RNAs. While Loqs coats the entire positive-stranded viral RNA, it binds selectively to the 3' end of the negative-strand of the viral genome. In-depth analyses showed that the absence of Loqs did not affect translation or turnover of the viral RNA but modulated viral replication. Loqs also displayed pro-viral functions for several flaviviruses in infected mosquito cells, suggesting a conserved role for Loqs in flavivirus-infected mosquito cells." @default.
• W4226501911 created "2022-05-05" @default.
• W4226501911 creator A5026014585 @default.
• W4226501911 creator A5046644865 @default.
• W4226501911 creator A5047539009 @default.
• W4226501911 creator A5049076606 @default.
• W4226501911 creator A5049480968 @default.
• W4226501911 creator A5085013623 @default.
• W4226501911 creator A5087299955 @default.
• W4226501911 date "2022-04-28" @default.
• W4226501911 modified "2023-09-30" @default.
• W4226501911 title "Loquacious modulates flaviviral RNA replication in mosquito cells" @default.
• W4226501911 cites W1238363289 @default.
• W4226501911 cites W1982965744 @default.
• W4226501911 cites W1999501439 @default.
• W4226501911 cites W2020962585 @default.
• W4226501911 cites W2023293746 @default.
• W4226501911 cites W2034879394 @default.
• W4226501911 cites W2034899234 @default.
• W4226501911 cites W2039772376 @default.
• W4226501911 cites W2088335903 @default.
• W4226501911 cites W2122657443 @default.
• W4226501911 cites W2125782175 @default.
• W4226501911 cites W2132813363 @default.
• W4226501911 cites W2169158245 @default.
• W4226501911 cites W2242410361 @default.
• W4226501911 cites W2259471848 @default.
• W4226501911 cites W2319911380 @default.
• W4226501911 cites W2342788749 @default.
• W4226501911 cites W2592268384 @default.
• W4226501911 cites W2610396252 @default.
• W4226501911 cites W2610869807 @default.
• W4226501911 cites W2768886517 @default.
• W4226501911 cites W2780475287 @default.
• W4226501911 cites W2783209472 @default.
• W4226501911 cites W2786230719 @default.
• W4226501911 cites W2791337732 @default.
• W4226501911 cites W2887795152 @default.
• W4226501911 cites W2890512924 @default.
• W4226501911 cites W2896675470 @default.
• W4226501911 cites W2904824676 @default.
• W4226501911 cites W2913600982 @default.
• W4226501911 cites W2944124211 @default.
• W4226501911 cites W2965607935 @default.
• W4226501911 cites W2971765750 @default.
• W4226501911 cites W3004599151 @default.
• W4226501911 cites W3093126660 @default.
• W4226501911 cites W3215697476 @default.
• W4226501911 cites W4211009269 @default.
• W4226501911 doi "https://doi.org/10.1371/journal.ppat.1010163" @default.
• W4226501911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35482886" @default.
• W4226501911 hasPublicationYear "2022" @default.
• W4226501911 type Work @default.
• W4226501911 citedByCount "2" @default.
• W4226501911 countsByYear W42265019112022 @default.
• W4226501911 countsByYear W42265019112023 @default.
• W4226501911 crossrefType "journal-article" @default.
• W4226501911 hasAuthorship W4226501911A5026014585 @default.
• W4226501911 hasAuthorship W4226501911A5046644865 @default.
• W4226501911 hasAuthorship W4226501911A5047539009 @default.
• W4226501911 hasAuthorship W4226501911A5049076606 @default.
• W4226501911 hasAuthorship W4226501911A5049480968 @default.
• W4226501911 hasAuthorship W4226501911A5085013623 @default.
• W4226501911 hasAuthorship W4226501911A5087299955 @default.
• W4226501911 hasBestOaLocation W42265019111 @default.
• W4226501911 hasConcept C104317684 @default.
• W4226501911 hasConcept C10852380 @default.
• W4226501911 hasConcept C140704245 @default.
• W4226501911 hasConcept C159047783 @default.
• W4226501911 hasConcept C189819185 @default.
• W4226501911 hasConcept C2522874641 @default.
• W4226501911 hasConcept C25897203 @default.
• W4226501911 hasConcept C2777627835 @default.
• W4226501911 hasConcept C2779635636 @default.
• W4226501911 hasConcept C2780568436 @default.
• W4226501911 hasConcept C2780879997 @default.
• W4226501911 hasConcept C533803919 @default.
• W4226501911 hasConcept C54355233 @default.
• W4226501911 hasConcept C58475186 @default.
• W4226501911 hasConcept C67705224 @default.
• W4226501911 hasConcept C86803240 @default.
• W4226501911 hasConcept C95444343 @default.
• W4226501911 hasConceptScore W4226501911C104317684 @default.
• W4226501911 hasConceptScore W4226501911C10852380 @default.
• W4226501911 hasConceptScore W4226501911C140704245 @default.
• W4226501911 hasConceptScore W4226501911C159047783 @default.
• W4226501911 hasConceptScore W4226501911C189819185 @default.
• W4226501911 hasConceptScore W4226501911C2522874641 @default.
• W4226501911 hasConceptScore W4226501911C25897203 @default.
• W4226501911 hasConceptScore W4226501911C2777627835 @default.
• W4226501911 hasConceptScore W4226501911C2779635636 @default.
• W4226501911 hasConceptScore W4226501911C2780568436 @default.
• W4226501911 hasConceptScore W4226501911C2780879997 @default.
• W4226501911 hasConceptScore W4226501911C533803919 @default.
• W4226501911 hasConceptScore W4226501911C54355233 @default.
• W4226501911 hasConceptScore W4226501911C58475186 @default.
• W4226501911 hasConceptScore W4226501911C67705224 @default.
• W4226501911 hasConceptScore W4226501911C86803240 @default.

• next