Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226508132> ?p ?o ?g. }
- W4226508132 abstract "Radiation-induced heart disease (RIHD) is a serious side effect of radiotherapy for thoracic tumors. Advanced myocardial fibrosis in the late phase of RIHD can lead to myocardial remodeling, heart function impairing and heart failure, resulting in serious clinical consequences, and its pathogenesis remains vague. DNA methylation is one of the important epigenetic mechanisms which often occurs in response to environmental stimuli and is crucial in regulating gene expression. We hypothesized DNA methylation may contribute to pathogenesis in radiation-induced heart fibrosis (RIHF) and altered DNA methylation patterns probably influenced the genes expression in RIHF. In present study, we found genome-wide differences in DNA methylation status and RNA expression were demonstrated and we screened out 44 genes whose altered expression maybe were regulated by CpG island methylation within the gene promoter in RIHF of Sprague-Dawley rat by employing gene expression arrays and human CpG island microarrays. Gene expression and CpG island methylation levels of several candidate genes were further validated. Our investigation provided a new dimension to reveal the specific mechanisms of RIHF and explore the potential therapeutic targets for it." @default.
- W4226508132 created "2022-05-05" @default.
- W4226508132 creator A5014862300 @default.
- W4226508132 creator A5029636776 @default.
- W4226508132 creator A5036018843 @default.
- W4226508132 creator A5048379858 @default.
- W4226508132 creator A5050227440 @default.
- W4226508132 creator A5054987593 @default.
- W4226508132 creator A5058963598 @default.
- W4226508132 creator A5083881916 @default.
- W4226508132 creator A5090366405 @default.
- W4226508132 date "2022-04-27" @default.
- W4226508132 modified "2023-10-06" @default.
- W4226508132 title "Altered DNA Methylation and Gene Expression Profiles in Radiation-Induced Heart Fibrosis of Sprague-Dawley Rats" @default.
- W4226508132 cites W1886031496 @default.
- W4226508132 cites W1973485587 @default.
- W4226508132 cites W1976398898 @default.
- W4226508132 cites W1992503611 @default.
- W4226508132 cites W1993536160 @default.
- W4226508132 cites W1996554914 @default.
- W4226508132 cites W2009804590 @default.
- W4226508132 cites W2011725251 @default.
- W4226508132 cites W2015184095 @default.
- W4226508132 cites W2027646678 @default.
- W4226508132 cites W2030248303 @default.
- W4226508132 cites W2033653350 @default.
- W4226508132 cites W2037883815 @default.
- W4226508132 cites W2044890358 @default.
- W4226508132 cites W2053028272 @default.
- W4226508132 cites W2060720812 @default.
- W4226508132 cites W2068510084 @default.
- W4226508132 cites W2068663150 @default.
- W4226508132 cites W2071719498 @default.
- W4226508132 cites W2079094767 @default.
- W4226508132 cites W2093573451 @default.
- W4226508132 cites W2094679415 @default.
- W4226508132 cites W2100856280 @default.
- W4226508132 cites W2122459462 @default.
- W4226508132 cites W2123995229 @default.
- W4226508132 cites W2126161397 @default.
- W4226508132 cites W2130685053 @default.
- W4226508132 cites W2159893642 @default.
- W4226508132 cites W2161661499 @default.
- W4226508132 cites W2164969738 @default.
- W4226508132 cites W2167436594 @default.
- W4226508132 cites W2168662701 @default.
- W4226508132 cites W2328243798 @default.
- W4226508132 cites W2605091048 @default.
- W4226508132 cites W2799993677 @default.
- W4226508132 cites W88212337 @default.
- W4226508132 doi "https://doi.org/10.1667/rade-20-00130.1" @default.
- W4226508132 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35476803" @default.
- W4226508132 hasPublicationYear "2022" @default.
- W4226508132 type Work @default.
- W4226508132 citedByCount "3" @default.
- W4226508132 countsByYear W42265081322022 @default.
- W4226508132 countsByYear W42265081322023 @default.
- W4226508132 crossrefType "journal-article" @default.
- W4226508132 hasAuthorship W4226508132A5014862300 @default.
- W4226508132 hasAuthorship W4226508132A5029636776 @default.
- W4226508132 hasAuthorship W4226508132A5036018843 @default.
- W4226508132 hasAuthorship W4226508132A5048379858 @default.
- W4226508132 hasAuthorship W4226508132A5050227440 @default.
- W4226508132 hasAuthorship W4226508132A5054987593 @default.
- W4226508132 hasAuthorship W4226508132A5058963598 @default.
- W4226508132 hasAuthorship W4226508132A5083881916 @default.
- W4226508132 hasAuthorship W4226508132A5090366405 @default.
- W4226508132 hasConcept C104317684 @default.
- W4226508132 hasConcept C140173407 @default.
- W4226508132 hasConcept C150194340 @default.
- W4226508132 hasConcept C165864922 @default.
- W4226508132 hasConcept C190727270 @default.
- W4226508132 hasConcept C33288867 @default.
- W4226508132 hasConcept C41091548 @default.
- W4226508132 hasConcept C502942594 @default.
- W4226508132 hasConcept C54355233 @default.
- W4226508132 hasConcept C86803240 @default.
- W4226508132 hasConcept C95371953 @default.
- W4226508132 hasConceptScore W4226508132C104317684 @default.
- W4226508132 hasConceptScore W4226508132C140173407 @default.
- W4226508132 hasConceptScore W4226508132C150194340 @default.
- W4226508132 hasConceptScore W4226508132C165864922 @default.
- W4226508132 hasConceptScore W4226508132C190727270 @default.
- W4226508132 hasConceptScore W4226508132C33288867 @default.
- W4226508132 hasConceptScore W4226508132C41091548 @default.
- W4226508132 hasConceptScore W4226508132C502942594 @default.
- W4226508132 hasConceptScore W4226508132C54355233 @default.
- W4226508132 hasConceptScore W4226508132C86803240 @default.
- W4226508132 hasConceptScore W4226508132C95371953 @default.
- W4226508132 hasIssue "2" @default.
- W4226508132 hasLocation W42265081321 @default.
- W4226508132 hasLocation W42265081322 @default.
- W4226508132 hasOpenAccess W4226508132 @default.
- W4226508132 hasPrimaryLocation W42265081321 @default.
- W4226508132 hasRelatedWork W1973778874 @default.
- W4226508132 hasRelatedWork W2091393239 @default.
- W4226508132 hasRelatedWork W2094569740 @default.
- W4226508132 hasRelatedWork W2412198229 @default.
- W4226508132 hasRelatedWork W2477521417 @default.
- W4226508132 hasRelatedWork W2724450141 @default.