FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4226524003> ?p ?o ?g. }

• W4226524003 endingPage "205873922210764" @default.
• W4226524003 startingPage "205873922210764" @default.
• W4226524003 abstract "Introduction: Generalized pustular psoriasis (GPP) is a chronic autoinflammatory disease characterized by fever, erythema, and sterile pustules occurring over large areas of the skin. The immunopathogenesis of GPP remains poorly understood. We aimed to profile serum cytokine levels in patients with GPP and analyze treatment-associated changes in cytokine levels. Methods: Twenty-four patients who were diagnosed with GPP and received drug treatment, together with 28 unaffected controls, were recruited in this study. Levels of 27 cytokines in serum samples from pre- and post-treated patients as well as unaffected controls were assessed using a Bio-Plex multiplex immunoassay. Multivariate analysis of cytokine levels and clinical parameters was conducted. Results: Serum levels of interleukins interleukin (IL)-1β, IL-1Ra, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12 (p70), IL-13, IL-17, granulocyte colony-stimulating factor (G-CSF), interferon-γ (IFN-γ), IFN-γ-induced protein 10 (IP-10), monocyte chemoattractant protein-1, tumor necrosis factor-α, and vascular endothelial growth factor were significantly elevated (p < .05) in patients with GPP compared with controls. Serum levels of IL-6, G-CSF, IL-8, IFN-γ, IL1-Ra, IL-10, IL-13, and IL-1β were correlated with GPP severity (r > 0.4, p < .001). Following treatment, serum levels of IL-6, IL-7, IL-12, IFN-γ, IL-1β, IL-4, IL-8, IL-10, IL-13, G-CSF, and IP-10 were significantly decreased (p < .05) compared with pretreatment levels. Among these cytokines, levels of IL-6, IL-7, IL-8, IL-12, IL-13, and IP-10 were reduced to normal levels. Conclusion: GPP patients exhibited markedly elevated levels of cytokines and chemokines involved in both type 1 and type 2 immune responses, suggesting hypercytokinemia occurs in GPP patients. IL-6 showed the strongest correlation with GPP disease severity and other clinical parameters such as CRP level and fever, thus representing an index for GPP severity. Our data comprehensively documented the cytokine profiles of GPP patients and may provide insights into GPP pathogenesis." @default.
• W4226524003 created "2022-05-05" @default.
• W4226524003 creator A5027907457 @default.
• W4226524003 creator A5028736495 @default.
• W4226524003 creator A5051000109 @default.
• W4226524003 date "2022-01-01" @default.
• W4226524003 modified "2023-10-18" @default.
• W4226524003 title "Profiling and multivariate analysis of serum cytokines in patients with generalized pustular psoriasis" @default.
• W4226524003 cites W1589956668 @default.
• W4226524003 cites W1716589462 @default.
• W4226524003 cites W2006072720 @default.
• W4226524003 cites W2095667188 @default.
• W4226524003 cites W2095996929 @default.
• W4226524003 cites W2162114723 @default.
• W4226524003 cites W2565131287 @default.
• W4226524003 cites W2743714815 @default.
• W4226524003 cites W2759138036 @default.
• W4226524003 cites W2766145635 @default.
• W4226524003 cites W2772378626 @default.
• W4226524003 cites W2792087291 @default.
• W4226524003 cites W2806479602 @default.
• W4226524003 cites W2807082322 @default.
• W4226524003 cites W2811171873 @default.
• W4226524003 cites W2913577069 @default.
• W4226524003 cites W3092829603 @default.
• W4226524003 cites W3107902125 @default.
• W4226524003 cites W3116096218 @default.
• W4226524003 cites W4233682577 @default.
• W4226524003 doi "https://doi.org/10.1177/20587392221076450" @default.
• W4226524003 hasPublicationYear "2022" @default.
• W4226524003 type Work @default.
• W4226524003 citedByCount "2" @default.
• W4226524003 countsByYear W42265240032023 @default.
• W4226524003 crossrefType "journal-article" @default.
• W4226524003 hasAuthorship W4226524003A5027907457 @default.
• W4226524003 hasAuthorship W4226524003A5028736495 @default.
• W4226524003 hasAuthorship W4226524003A5051000109 @default.
• W4226524003 hasBestOaLocation W42265240031 @default.
• W4226524003 hasConcept C126322002 @default.
• W4226524003 hasConcept C156730664 @default.
• W4226524003 hasConcept C17991360 @default.
• W4226524003 hasConcept C203014093 @default.
• W4226524003 hasConcept C2776907424 @default.
• W4226524003 hasConcept C2778690821 @default.
• W4226524003 hasConcept C2780564577 @default.
• W4226524003 hasConcept C47348012 @default.
• W4226524003 hasConcept C71924100 @default.
• W4226524003 hasConcept C74172505 @default.
• W4226524003 hasConceptScore W4226524003C126322002 @default.
• W4226524003 hasConceptScore W4226524003C156730664 @default.
• W4226524003 hasConceptScore W4226524003C17991360 @default.
• W4226524003 hasConceptScore W4226524003C203014093 @default.
• W4226524003 hasConceptScore W4226524003C2776907424 @default.
• W4226524003 hasConceptScore W4226524003C2778690821 @default.
• W4226524003 hasConceptScore W4226524003C2780564577 @default.
• W4226524003 hasConceptScore W4226524003C47348012 @default.
• W4226524003 hasConceptScore W4226524003C71924100 @default.
• W4226524003 hasConceptScore W4226524003C74172505 @default.
• W4226524003 hasFunder F4320321001 @default.
• W4226524003 hasFunder F4320335777 @default.
• W4226524003 hasLocation W42265240031 @default.
• W4226524003 hasOpenAccess W4226524003 @default.
• W4226524003 hasPrimaryLocation W42265240031 @default.
• W4226524003 hasRelatedWork W1915760257 @default.
• W4226524003 hasRelatedWork W1999339423 @default.
• W4226524003 hasRelatedWork W2017423448 @default.
• W4226524003 hasRelatedWork W2108063808 @default.
• W4226524003 hasRelatedWork W2358496962 @default.
• W4226524003 hasRelatedWork W2385142678 @default.
• W4226524003 hasRelatedWork W2522433031 @default.
• W4226524003 hasRelatedWork W3031081582 @default.
• W4226524003 hasRelatedWork W3080367034 @default.
• W4226524003 hasRelatedWork W3209018430 @default.
• W4226524003 hasVolume "20" @default.
• W4226524003 isParatext "false" @default.
• W4226524003 isRetracted "false" @default.
• W4226524003 workType "article" @default.