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• W4226543000 abstract "<ns3:p><ns3:bold>Background: </ns3:bold>The gene <ns3:italic>FOXO3a</ns3:italic> has been elucidated to govern the development of chronic granulocytic leukemia (CGL). Moreover, it has been suggested that the levels of <ns3:italic>FOXO3a</ns3:italic> in circulation are affected by the<ns3:italic> FOXO3a</ns3:italic> rs4946936 gene polymorphism. However, no study has assessed the correlation between the <ns3:italic>FOXO3a</ns3:italic> rs4946936 gene polymorphism and the levels of<ns3:italic> FOXO3a</ns3:italic>. The objective of this study was to assess the association between the <ns3:italic>FOXO3a</ns3:italic> rs4946936 gene polymorphism and the levels of <ns3:italic>FOXO3a</ns3:italic> in CGL patients treated with imatinib mesylate. </ns3:p><ns3:p> <ns3:bold>Methods:</ns3:bold> A cross-sectional study was conducted from February 2019 to February 2020. The genotyping of <ns3:italic>FOXO3a</ns3:italic> rs4946936 gene polymorphism was conducted using PCR-RFLP, and the levels of <ns3:italic>FOXO3a</ns3:italic> were assessed using ELISA. The association between the <ns3:italic>FOXO3a</ns3:italic> rs4946936 gene polymorphism and the levels of <ns3:italic>FOXO3a</ns3:italic> were assessed using multiple logistic regression. </ns3:p><ns3:p> <ns3:bold>Results:</ns3:bold> A total of 60 CGL patients were assessed in our study. Among them, the CC, CT, and TT genotypes of the <ns3:italic>FOXO3a</ns3:italic> rs4946936 gene polymorphism were 35.0%, 48.3%, and 16.7% respectively. Our calculation revealed that elevated levels of <ns3:italic>FOXO3a</ns3:italic> were found in CGL patients with the CC genotype of the <ns3:italic>FOXO3a</ns3:italic> rs4946936 gene polymorphism. While we failed to clarify the association between either the CT or the TT genotype of <ns3:italic>FOXO3a</ns3:italic> rs4946936 gene polymorphism and the levels of <ns3:italic>FOXO3a</ns3:italic>. </ns3:p><ns3:p> <ns3:bold>Conclusion:</ns3:bold> Our study identifies that the CC genotype of the <ns3:italic>FOXO3a</ns3:italic> rs4946936 gene polymorphism affects the elevated levels of <ns3:italic>FOXO3a</ns3:italic> in CGL patients treated with imatinib mesylate.</ns3:p>" @default.
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• W4226543000 date "2022-04-11" @default.
• W4226543000 modified "2023-10-14" @default.
• W4226543000 title "The association between FOXO3a rs4946936 gene polymorphism and the levels of FOXO3a among chronic granulocytic leukemia patients treated with imatinib mesylate" @default.
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• W4226543000 doi "https://doi.org/10.12688/f1000research.73054.3" @default.
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