Matches in SemOpenAlex for { <https://semopenalex.org/work/W4228996814> ?p ?o ?g. }
- W4228996814 abstract "Abstract Conservation of thermally sensitive species depends on monitoring organismal and population-level responses to environmental change in real time. Epigenetic processes are increasingly recognized as key integrators of environmental conditions into developmentally plastic responses, and attendant epigenomic datasets hold potential for revealing cryptic phenotypes relevant to conservation efforts. Here, we demonstrate the utility of genome-wide DNA methylation (DNAm) patterns in the face of climate change for a group of especially vulnerable species, those with temperature-dependent sex determination (TSD). Due to their reliance on thermal cues during development to determine sexual fate, contemporary shifts in temperature are predicted to skew offspring sex ratios and ultimately destabilize sensitive populations. Using reduced-representation bisulfite sequencing, we profiled the DNA methylome in blood cells of hatchling American alligator ( Alligator mississippiensis ), a TSD species lacking reliable markers of sexual dimorphism in early life-stages. We identified 120 sex-associated differentially methylated cytosines (DMCs; FDR < 0.1) in hatchlings incubated under a range of temperatures, as well as 707 unique temperature-associated DMCs. We further developed DNAm-based models capable of predicting hatchling sex with 100% accuracy and past incubation temperature with a mean absolute error of 1.2°C based on the methylation status of 20 and 24 loci, respectively. Though largely independent of epigenomic patterning occurring in the embryonic gonad during TSD, DNAm patterns in blood cells may serve as non-lethal markers of hatchling sex and past incubation conditions in conservation applications. These findings also raise intriguing questions regarding tissue-specific epigenomic patterning in the context of developmental plasticity." @default.
- W4228996814 created "2022-05-08" @default.
- W4228996814 creator A5002163110 @default.
- W4228996814 creator A5017804044 @default.
- W4228996814 creator A5024234279 @default.
- W4228996814 creator A5055509841 @default.
- W4228996814 date "2022-05-04" @default.
- W4228996814 modified "2023-09-26" @default.
- W4228996814 title "Genome-wide DNA methylation patterns harbor signatures of hatchling sex and past incubation temperature in a species with environmental sex determination" @default.
- W4228996814 cites W1502318192 @default.
- W4228996814 cites W1871958920 @default.
- W4228996814 cites W1893475041 @default.
- W4228996814 cites W1966327575 @default.
- W4228996814 cites W1967116629 @default.
- W4228996814 cites W1967841068 @default.
- W4228996814 cites W1972152629 @default.
- W4228996814 cites W1974047233 @default.
- W4228996814 cites W1977087590 @default.
- W4228996814 cites W1982690749 @default.
- W4228996814 cites W1984374510 @default.
- W4228996814 cites W1985267478 @default.
- W4228996814 cites W1987736972 @default.
- W4228996814 cites W1996423252 @default.
- W4228996814 cites W1997866877 @default.
- W4228996814 cites W2008059407 @default.
- W4228996814 cites W2044722972 @default.
- W4228996814 cites W2055237453 @default.
- W4228996814 cites W2073839595 @default.
- W4228996814 cites W2074452993 @default.
- W4228996814 cites W2077359776 @default.
- W4228996814 cites W2095850322 @default.
- W4228996814 cites W2096863518 @default.
- W4228996814 cites W2098872748 @default.
- W4228996814 cites W2102619694 @default.
- W4228996814 cites W2107880367 @default.
- W4228996814 cites W2108234281 @default.
- W4228996814 cites W2111485719 @default.
- W4228996814 cites W2113291597 @default.
- W4228996814 cites W2114482264 @default.
- W4228996814 cites W2117300263 @default.
- W4228996814 cites W2122825543 @default.
- W4228996814 cites W2131374955 @default.
- W4228996814 cites W2131478115 @default.
- W4228996814 cites W2143858605 @default.
- W4228996814 cites W2149206894 @default.
- W4228996814 cites W2150194502 @default.
- W4228996814 cites W2154198786 @default.
- W4228996814 cites W2155920093 @default.
- W4228996814 cites W2162758781 @default.
- W4228996814 cites W2163327652 @default.
- W4228996814 cites W2166071110 @default.
- W4228996814 cites W2170551349 @default.
- W4228996814 cites W2171783560 @default.
- W4228996814 cites W2263792923 @default.
- W4228996814 cites W2311472547 @default.
- W4228996814 cites W2329824015 @default.
- W4228996814 cites W2330784827 @default.
- W4228996814 cites W2331177914 @default.
- W4228996814 cites W2409916764 @default.
- W4228996814 cites W2432815617 @default.
- W4228996814 cites W2444147361 @default.
- W4228996814 cites W2462588738 @default.
- W4228996814 cites W2494121918 @default.
- W4228996814 cites W2497879403 @default.
- W4228996814 cites W2513975280 @default.
- W4228996814 cites W2520345180 @default.
- W4228996814 cites W2520441519 @default.
- W4228996814 cites W2529295855 @default.
- W4228996814 cites W2541033308 @default.
- W4228996814 cites W2612732481 @default.
- W4228996814 cites W2625357100 @default.
- W4228996814 cites W2626134292 @default.
- W4228996814 cites W2741460810 @default.
- W4228996814 cites W2747178840 @default.
- W4228996814 cites W2755635242 @default.
- W4228996814 cites W2762623015 @default.
- W4228996814 cites W2765762279 @default.
- W4228996814 cites W2769268193 @default.
- W4228996814 cites W2774486220 @default.
- W4228996814 cites W2782183756 @default.
- W4228996814 cites W2782965135 @default.
- W4228996814 cites W2790023639 @default.
- W4228996814 cites W2794480084 @default.
- W4228996814 cites W2796559433 @default.
- W4228996814 cites W2800391176 @default.
- W4228996814 cites W2802181291 @default.
- W4228996814 cites W2808778851 @default.
- W4228996814 cites W2885190329 @default.
- W4228996814 cites W2885535623 @default.
- W4228996814 cites W2894083868 @default.
- W4228996814 cites W2943598729 @default.
- W4228996814 cites W2943911702 @default.
- W4228996814 cites W2949813177 @default.
- W4228996814 cites W2953209411 @default.
- W4228996814 cites W2959182110 @default.
- W4228996814 cites W2976599540 @default.
- W4228996814 cites W2979092185 @default.
- W4228996814 cites W2982300999 @default.
- W4228996814 cites W3000026902 @default.
- W4228996814 cites W3000247917 @default.