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- W4228996896 abstract "Obesity has become a major health crisis in the past ∼50 years. The fat mass and obesity-associated (FTO) gene, identified by genome-wide association studies (GWAS), was first reported to be positively associated with obesity in humans. Mice with more copies of the FTO gene were observed to be obese, while loss of the gene in mice was found to protect from obesity. Later, FTO was found to encode an m6A RNA demethylase and has a profound effect on many biological and metabolic processes. In this review, we first summarize recent studies that demonstrate the critical roles and regulatory mechanisms of FTO in obesity and metabolic disease. Second, we discuss the ongoing debates concerning the association between FTO polymorphisms and obesity. Third, since several small molecule drugs and micronutrients have been found to regulate metabolic homeostasis through controlling the expression or activity of FTO, we highlight the broad potential of targeting FTO for obesity treatment. Improving our understanding of FTO and the underlying mechanisms may provide new approaches for treating obesity and metabolic diseases." @default.
- W4228996896 created "2022-05-08" @default.
- W4228996896 creator A5015904152 @default.
- W4228996896 creator A5017541508 @default.
- W4228996896 creator A5054076684 @default.
- W4228996896 date "2023-11-01" @default.
- W4228996896 modified "2023-09-22" @default.
- W4228996896 title "Studies on the fat mass and obesity-associated (FTO) gene and its impact on obesity-associated diseases" @default.
- W4228996896 cites W1531812226 @default.
- W4228996896 cites W1537096814 @default.
- W4228996896 cites W1636205509 @default.
- W4228996896 cites W1868335994 @default.
- W4228996896 cites W1898417974 @default.
- W4228996896 cites W1933156045 @default.
- W4228996896 cites W1944558458 @default.
- W4228996896 cites W1963603805 @default.
- W4228996896 cites W1972021276 @default.
- W4228996896 cites W1976844911 @default.
- W4228996896 cites W1981213880 @default.
- W4228996896 cites W1981446212 @default.
- W4228996896 cites W1983270011 @default.
- W4228996896 cites W1986694219 @default.
- W4228996896 cites W1987923869 @default.
- W4228996896 cites W1989491629 @default.
- W4228996896 cites W1990598085 @default.
- W4228996896 cites W1991807334 @default.
- W4228996896 cites W1991838121 @default.
- W4228996896 cites W1992371157 @default.
- W4228996896 cites W1992883031 @default.
- W4228996896 cites W1994033656 @default.
- W4228996896 cites W1996446155 @default.
- W4228996896 cites W1997040114 @default.
- W4228996896 cites W1999478182 @default.
- W4228996896 cites W2002107339 @default.
- W4228996896 cites W2002848248 @default.
- W4228996896 cites W2003629248 @default.
- W4228996896 cites W2006704526 @default.
- W4228996896 cites W2009315890 @default.
- W4228996896 cites W2011969894 @default.
- W4228996896 cites W2012215886 @default.
- W4228996896 cites W2015217788 @default.
- W4228996896 cites W2015696149 @default.
- W4228996896 cites W2018436715 @default.
- W4228996896 cites W2019607502 @default.
- W4228996896 cites W2028335133 @default.
- W4228996896 cites W2034126438 @default.
- W4228996896 cites W2039650829 @default.
- W4228996896 cites W2040964350 @default.
- W4228996896 cites W2040981175 @default.
- W4228996896 cites W2042765650 @default.
- W4228996896 cites W2043785033 @default.
- W4228996896 cites W2045164343 @default.
- W4228996896 cites W2048069174 @default.
- W4228996896 cites W2050281909 @default.
- W4228996896 cites W2051584795 @default.
- W4228996896 cites W2055898909 @default.
- W4228996896 cites W2059572967 @default.
- W4228996896 cites W2060435849 @default.
- W4228996896 cites W2060779392 @default.
- W4228996896 cites W2062886649 @default.
- W4228996896 cites W2065847836 @default.
- W4228996896 cites W2067515559 @default.
- W4228996896 cites W2070021921 @default.
- W4228996896 cites W2070348851 @default.
- W4228996896 cites W2071930821 @default.
- W4228996896 cites W2073582448 @default.
- W4228996896 cites W2077872184 @default.
- W4228996896 cites W2078964320 @default.
- W4228996896 cites W2079171740 @default.
- W4228996896 cites W2079660217 @default.
- W4228996896 cites W2080933533 @default.
- W4228996896 cites W2082122713 @default.
- W4228996896 cites W2084697100 @default.
- W4228996896 cites W2085860799 @default.
- W4228996896 cites W2086635253 @default.
- W4228996896 cites W2089536324 @default.
- W4228996896 cites W2092055708 @default.
- W4228996896 cites W2092207134 @default.
- W4228996896 cites W2092242601 @default.
- W4228996896 cites W2092625960 @default.
- W4228996896 cites W2093071388 @default.
- W4228996896 cites W2097620334 @default.
- W4228996896 cites W2097660065 @default.
- W4228996896 cites W2099247534 @default.
- W4228996896 cites W2105453679 @default.
- W4228996896 cites W2107294782 @default.
- W4228996896 cites W2107471012 @default.
- W4228996896 cites W2110678911 @default.
- W4228996896 cites W2112247200 @default.
- W4228996896 cites W2113895001 @default.
- W4228996896 cites W2114919053 @default.
- W4228996896 cites W2117053787 @default.
- W4228996896 cites W2119051762 @default.
- W4228996896 cites W2119459661 @default.
- W4228996896 cites W2121374985 @default.
- W4228996896 cites W2121819193 @default.
- W4228996896 cites W2122767064 @default.
- W4228996896 cites W2125121177 @default.