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- W4228996911 abstract "Epigenetic inheritance can result in plastic responses to changing environments being faithfully transmitted to offspring. However, it remains unclear how epigenetic mechanisms such as DNA methylation can contribute to multigenerational acclimation and adaptation to environmental stressors. Brook charr ( Salvelinus fontinalis ), an economically important salmonid, is highly sensitive to thermal stress and is of conservation concern in the context of climate change. We studied the effects of temperature during parental sexual maturation and offspring rearing on whole-genome DNA methylation in brook charr juveniles (fry). Parents were split between warm and cold temperatures during sexual maturation, mated in controlled breeding designs, then offspring from each family were split between warm (8°C) and cold (5°C) rearing environments. Using whole-genome bisulfite sequencing, we found 188 differentially methylated regions (DMRs) due to parental maturation temperature after controlling for family structure. By contrast, offspring rearing temperature had a negligible effect on offspring methylation. Stable intergenerational inheritance of DNA methylation and minimal plasticity in progeny could result in the transmission of acclimatory epigenetic states to offspring, priming them for a warming environment. Our findings have implications pertaining to the role of intergenerational epigenetic inheritance in response to ongoing climate change." @default.
- W4228996911 created "2022-05-08" @default.
- W4228996911 creator A5001675482 @default.
- W4228996911 creator A5003015150 @default.
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- W4228996911 creator A5017051404 @default.
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- W4228996911 creator A5088643517 @default.
- W4228996911 date "2022-05-04" @default.
- W4228996911 modified "2023-10-14" @default.
- W4228996911 title "Thermal regime during parental sexual maturation, but not during offspring rearing, modulates DNA methylation in brook charr ( <i>Salvelinus fontinalis</i> )" @default.
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