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• W4228999496 abstract "Non-typhoidal Salmonella (NTS) is a major cause of bacterial enterocolitis globally but also causes invasive bloodstream infections. Antimicrobial resistance (AMR) hampers the treatment of these infections and understanding how AMR spreads between NTS may help in developing effective strategies. We investigated NTS isolates associated with invasive disease, diarrhoeal disease and asymptomatic carriage in animals and humans from Vietnam. Isolates included multiple serovars and both common and rare phenotypic AMR profiles; long- and short-read sequencing was used to investigate the genetic mechanisms and genomic backgrounds associated with phenotypic AMR profiles. We demonstrate concordance between most AMR genotypes and phenotypes but identified large genotypic diversity in clinically relevant phenotypes and the high mobility potential of AMR genes (ARGs) in this setting. We found that 84 % of ARGs identified were located on plasmids, most commonly those containing IncHI1A_1 and IncHI1B(R27)_1_R27 replicons (33%), and those containing IncHI2_1 and IncHI2A_1 replicons (31%). The vast majority (95%) of ARGS were found within 10 kbp of IS6/IS26 elements, which provide plasmids with a mechanism to exchange ARGs between plasmids and other parts of the genome. Whole genome sequencing with targeted long-read sequencing applied in a One Health context identified a comparatively limited number of insertion sequences and plasmid replicons associated with AMR. Therefore, in the context of NTS from Vietnam and likely for other settings as well, the mechanisms by which ARGs move contribute to a more successful AMR profile than the specific ARGs, facilitating the adaptation of bacteria to different environments or selection pressures." @default.
• W4228999496 created "2022-05-08" @default.
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• W4228999496 date "2022-05-05" @default.
• W4228999496 modified "2023-10-09" @default.
• W4228999496 title "Mobility of antimicrobial resistance across serovars and disease presentations in non-typhoidal Salmonella from animals and humans in Vietnam" @default.
• W4228999496 cites W1601962946 @default.
• W4228999496 cites W1955626595 @default.
• W4228999496 cites W1973375098 @default.
• W4228999496 cites W1982855075 @default.
• W4228999496 cites W1987490623 @default.
• W4228999496 cites W1991860284 @default.
• W4228999496 cites W2016084211 @default.
• W4228999496 cites W2017137468 @default.
• W4228999496 cites W2027184506 @default.
• W4228999496 cites W2041758469 @default.
• W4228999496 cites W2055043387 @default.
• W4228999496 cites W2066757268 @default.
• W4228999496 cites W2067136681 @default.
• W4228999496 cites W2074206742 @default.
• W4228999496 cites W2082047673 @default.
• W4228999496 cites W2086788514 @default.
• W4228999496 cites W2089440185 @default.
• W4228999496 cites W2096093282 @default.
• W4228999496 cites W2098143905 @default.
• W4228999496 cites W2099730013 @default.
• W4228999496 cites W2100034360 @default.
• W4228999496 cites W2101997581 @default.
• W4228999496 cites W2103441770 @default.
• W4228999496 cites W2105245948 @default.
• W4228999496 cites W2105937538 @default.
• W4228999496 cites W2114853012 @default.
• W4228999496 cites W2116744776 @default.
• W4228999496 cites W2117075449 @default.
• W4228999496 cites W2122673596 @default.
• W4228999496 cites W2131271579 @default.
• W4228999496 cites W2132530250 @default.
• W4228999496 cites W2134852597 @default.
• W4228999496 cites W2139580695 @default.
• W4228999496 cites W2141052558 @default.
• W4228999496 cites W2143325926 @default.
• W4228999496 cites W2153416750 @default.
• W4228999496 cites W2157025252 @default.
• W4228999496 cites W2157539385 @default.
• W4228999496 cites W2159949205 @default.
• W4228999496 cites W2173913502 @default.
• W4228999496 cites W2345791363 @default.
• W4228999496 cites W2346571412 @default.
• W4228999496 cites W2508631845 @default.
• W4228999496 cites W2512844942 @default.
• W4228999496 cites W2557681842 @default.
• W4228999496 cites W2588754019 @default.
• W4228999496 cites W2597781578 @default.
• W4228999496 cites W2623047193 @default.
• W4228999496 cites W2693650708 @default.
• W4228999496 cites W2726257503 @default.
• W4228999496 cites W2726286722 @default.
• W4228999496 cites W2742299527 @default.
• W4228999496 cites W2766214515 @default.
• W4228999496 cites W2768188488 @default.
• W4228999496 cites W2776284994 @default.
• W4228999496 cites W2788228074 @default.
• W4228999496 cites W2791781902 @default.
• W4228999496 cites W2792034759 @default.
• W4228999496 cites W2803474517 @default.
• W4228999496 cites W2883838322 @default.
• W4228999496 cites W2887360247 @default.
• W4228999496 cites W2890209386 @default.
• W4228999496 cites W2890599573 @default.
• W4228999496 cites W2902200409 @default.
• W4228999496 cites W2905909361 @default.
• W4228999496 cites W2941799199 @default.
• W4228999496 cites W2943223175 @default.
• W4228999496 cites W2946717857 @default.
• W4228999496 cites W2950058687 @default.
• W4228999496 cites W2950826269 @default.
• W4228999496 cites W2951852653 @default.
• W4228999496 cites W2952167528 @default.
• W4228999496 cites W2952620784 @default.
• W4228999496 cites W2954326508 @default.
• W4228999496 cites W2954923154 @default.
• W4228999496 cites W2966516262 @default.
• W4228999496 cites W2971630607 @default.
• W4228999496 cites W2982290461 @default.
• W4228999496 cites W2982596781 @default.
• W4228999496 cites W2984919370 @default.

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