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• W4229000000 abstract "Patients with Parkinson's and Huntington's Disease (PD and HD) present impairments in cognitively challenging everyday activities. This study contrasts these two basal ganglia disorders on the ability to perform daily life- like tasks and their level of awareness regarding the disease impact on function.19 controls, 10 early-onset PD, 20 early stage PD, and 15 early manifest HD patients were compared in the EcoKitchen, a virtual reality task with increasing executive load, the Behavioural Assessment of Dysexecutive Syndrome battery - BADS, and The Adults and Older Adults Functional Assessment Inventory - IAFAI, a self-report functional questionnaire. The EcoKitchen clinical correlates were investigated.All clinical groups presented slower EcoKitchen performance than controls, however, only HD patients showed decreased accuracy. HD and PD patients exhibited reduced BADS scores compared to the other study participants. Importantly, on the IAFAI, PD patients signalled more physically related incapacities and HD patients indicated more cognitively related incapacities. Accordingly, the EcoKitchen performance was significantly associated with PD motor symptom severity.Our findings suggest differential disease impact on cognition and function across PD and HD patients, with preserved awareness regarding disease- related functional sequelae. These observations have important implications for clinical management, research and rehabilitation.Implications for rehabilitationPatients with early stage Parkinson's and Huntington's disease have diagnosis-specific impairments in the performance of executively demanding everyday activities and, yet, show preserved awareness about the disease impact on their daily life.An active involvement of patients in the rehabilitation process should be encouraged, as their appraisal of the disease effects can help on practical decisions about meaningful targets for intervention, vocational choices, quality-of-life issues and/or specific everyday skills to boost.The EcoKitchen, a non-immersive virtual reality task, can detect and quantify early deficits in everyday-like tasks and is therefore a valuable tool for assessing the effects of rehabilitation strategies on the functional cognition of these patients.Rehabilitation efforts in the mild stages of Parkinson's and Huntington's disease should be aware of greater time needs from the patients in the performance of daily life tasks, target executive skills, and give a more prominent role to patients in symptoms report and management." @default.
• W4229000000 created "2022-05-08" @default.
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• W4229000000 date "2020-07-03" @default.
• W4229000000 modified "2023-10-14" @default.
• W4229000000 title "Cognition, function and awareness of disease impact in early Parkinson’s and Huntington’s disease" @default.
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