FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229002745> ?p ?o ?g. }

• W4229002745 abstract "Abstract While T cell receptor (TCR)-modified T cell therapies have shown promise against solid tumors, overall therapeutic benefits in clinical practice have been modest due in part to suboptimal T cell persistence and activation in vivo, alongside the possibility of tumor antigen escape. In this study, we demonstrate an approach to enhance the in vivo persistence and activation of TCR-T cells through combination with Amphiphile (AMP)-vaccination including cognate TCR-T peptides. AMP-modification improves lymph node targeting of conjugated tumor immunogens and adjuvants, thereby coordinating a robust T cell-priming endogenous immune response. Vaccine combination with TCR-T cell therapy provided simultaneous in vivo invigoration of adoptively transferred TCR-T cells and in situ priming of the endogenous anti-tumor T cell repertoire. The resulting induction of an adoptive and endogenous anti-tumor effect led to durable responses in established murine solid tumors refractory to TCR-T cell monotherapy. Protection against recurrence was associated with antigen spreading to additional tumor-associated antigens not targeted by vaccination. Enhanced anti-tumor efficacy was further correlated with pro-inflammatory lymph node transcriptional reprogramming and increased antigen presenting cell maturation, resulting in TCR-T cell expansion and functional enhancement in lymph nodes and solid tumor parenchyma without lymphodepletion. In vitro evaluation of AMP-peptides with matched human TCR-T cells targeting NY-ESO-1, mutant KRAS, and HPV16 E7 illustrated the clinical potential of AMP-vaccination to enhance human TCR-T cell proliferation, activation, and anti-tumor activity. Taken together, these studies provide rationale and evidence to support clinical evaluation of the combination of AMP-vaccination with TCR-T cell therapies to augment anti-tumor activity. Summary AMP-vaccination targets the lymph nodes to enhance TCR-T cell therapy resulting in solid tumor eradication and durable protection against recurrence." @default.
• W4229002745 created "2022-05-08" @default.
• W4229002745 creator A5000063551 @default.
• W4229002745 creator A5019474976 @default.
• W4229002745 creator A5023437514 @default.
• W4229002745 creator A5045617677 @default.
• W4229002745 creator A5059987828 @default.
• W4229002745 creator A5061924480 @default.
• W4229002745 creator A5067675868 @default.
• W4229002745 creator A5082816021 @default.
• W4229002745 date "2022-05-05" @default.
• W4229002745 modified "2023-10-01" @default.
• W4229002745 title "Lymph node-targeted vaccine boosting of TCR-T cell therapy enhances anti-tumor 1 function and eradicates solid tumors" @default.
• W4229002745 cites W1963522404 @default.
• W4229002745 cites W2000853857 @default.
• W4229002745 cites W2017209592 @default.
• W4229002745 cites W2020312840 @default.
• W4229002745 cites W2046562334 @default.
• W4229002745 cites W2051549641 @default.
• W4229002745 cites W2054234238 @default.
• W4229002745 cites W2094652659 @default.
• W4229002745 cites W2108706633 @default.
• W4229002745 cites W2118796952 @default.
• W4229002745 cites W2120072658 @default.
• W4229002745 cites W2132713837 @default.
• W4229002745 cites W2136371915 @default.
• W4229002745 cites W2141410122 @default.
• W4229002745 cites W2145985838 @default.
• W4229002745 cites W2161684993 @default.
• W4229002745 cites W2165119413 @default.
• W4229002745 cites W2170513194 @default.
• W4229002745 cites W2188940973 @default.
• W4229002745 cites W2204416339 @default.
• W4229002745 cites W2343125831 @default.
• W4229002745 cites W2530185890 @default.
• W4229002745 cites W2534772180 @default.
• W4229002745 cites W2556133499 @default.
• W4229002745 cites W2567415894 @default.
• W4229002745 cites W2586164131 @default.
• W4229002745 cites W2586368282 @default.
• W4229002745 cites W2586691160 @default.
• W4229002745 cites W2617490000 @default.
• W4229002745 cites W2754607948 @default.
• W4229002745 cites W2754767805 @default.
• W4229002745 cites W2763751953 @default.
• W4229002745 cites W2802344779 @default.
• W4229002745 cites W2807603420 @default.
• W4229002745 cites W2808820218 @default.
• W4229002745 cites W2836754285 @default.
• W4229002745 cites W2895610076 @default.
• W4229002745 cites W2902963806 @default.
• W4229002745 cites W2916895208 @default.
• W4229002745 cites W2922068441 @default.
• W4229002745 cites W2957969985 @default.
• W4229002745 cites W2966041852 @default.
• W4229002745 cites W2998563599 @default.
• W4229002745 cites W3102422330 @default.
• W4229002745 cites W3128277750 @default.
• W4229002745 doi "https://doi.org/10.1101/2022.05.05.490779" @default.
• W4229002745 hasPublicationYear "2022" @default.
• W4229002745 type Work @default.
• W4229002745 citedByCount "1" @default.
• W4229002745 countsByYear W42290027452023 @default.
• W4229002745 crossrefType "posted-content" @default.
• W4229002745 hasAuthorship W4229002745A5000063551 @default.
• W4229002745 hasAuthorship W4229002745A5019474976 @default.
• W4229002745 hasAuthorship W4229002745A5023437514 @default.
• W4229002745 hasAuthorship W4229002745A5045617677 @default.
• W4229002745 hasAuthorship W4229002745A5059987828 @default.
• W4229002745 hasAuthorship W4229002745A5061924480 @default.
• W4229002745 hasAuthorship W4229002745A5067675868 @default.
• W4229002745 hasAuthorship W4229002745A5082816021 @default.
• W4229002745 hasBestOaLocation W42290027451 @default.
• W4229002745 hasConcept C100701293 @default.
• W4229002745 hasConcept C147483822 @default.
• W4229002745 hasConcept C19317047 @default.
• W4229002745 hasConcept C203014093 @default.
• W4229002745 hasConcept C2776090121 @default.
• W4229002745 hasConcept C2776662205 @default.
• W4229002745 hasConcept C2777701055 @default.
• W4229002745 hasConcept C2780849966 @default.
• W4229002745 hasConcept C502942594 @default.
• W4229002745 hasConcept C59822182 @default.
• W4229002745 hasConcept C71924100 @default.
• W4229002745 hasConcept C81444415 @default.
• W4229002745 hasConcept C86803240 @default.
• W4229002745 hasConcept C8891405 @default.
• W4229002745 hasConcept C90375314 @default.
• W4229002745 hasConceptScore W4229002745C100701293 @default.
• W4229002745 hasConceptScore W4229002745C147483822 @default.
• W4229002745 hasConceptScore W4229002745C19317047 @default.
• W4229002745 hasConceptScore W4229002745C203014093 @default.
• W4229002745 hasConceptScore W4229002745C2776090121 @default.
• W4229002745 hasConceptScore W4229002745C2776662205 @default.
• W4229002745 hasConceptScore W4229002745C2777701055 @default.
• W4229002745 hasConceptScore W4229002745C2780849966 @default.
• W4229002745 hasConceptScore W4229002745C502942594 @default.
• W4229002745 hasConceptScore W4229002745C59822182 @default.
• W4229002745 hasConceptScore W4229002745C71924100 @default.
• W4229002745 hasConceptScore W4229002745C81444415 @default.

• next