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- W4229002952 abstract "Respiratory syncytial virus (RSV) is a seasonal pathogen responsible for the highest percentage of viral bronchiolitis in pediatric patients. There are currently no vaccine available and therapeutic methods to mitigate the severity of RSV bronchiolitis are limited. OM-85, an oral standardized bacterial lysate isolated from human respiratory strains and widely used to prevent recurrent infections and/or exacerbations in populations at risk, has been shown to be effective and safe in children and adults. Here, we demonstrate that airway administration of OM-85 in Balb/c mice prior to infection prevents RSV-induced disease, resulting in inhibition of viral replication associated with less perivascular and peribronchial inflammation in the lungs. These protective effects are dose and time-dependent with complete protection using 1mg dose of OM-85 only four times intranasally. Mechanistic insights using this topical route in the airways revealed increased alveolar macrophages, a selective set of tolerogenic DCs, Treg and Th1 expansion in the lung, even in the absence of infection, contributing to a better Th1/Th2 balance and preventing ILC2 recruitment in the airways and associated inflammatory sequelae. OM-85 preventive treatment also improved antiviral response by increasing IFNβ and its responsive genes in the lung. In vitro , OM-85 protects against RSV infection in a type I interferon pathway. Our animal model data suggest that intranasal use of OM-85 should be considered as a potential prophylactic product to prevent RSV bronchiolitis once human studies confirm these findings." @default.
- W4229002952 created "2022-05-08" @default.
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- W4229002952 date "2022-05-05" @default.
- W4229002952 modified "2023-10-09" @default.
- W4229002952 title "Airway Administration of Bacterial Lysate OM-85 Protects Mice Against Respiratory Syncytial Virus Infection" @default.
- W4229002952 cites W1506108620 @default.
- W4229002952 cites W1528331455 @default.
- W4229002952 cites W1877854700 @default.
- W4229002952 cites W1970594708 @default.
- W4229002952 cites W1971972737 @default.
- W4229002952 cites W2000714505 @default.
- W4229002952 cites W2015916493 @default.
- W4229002952 cites W2029771914 @default.
- W4229002952 cites W2050047704 @default.
- W4229002952 cites W2095542631 @default.
- W4229002952 cites W2101114010 @default.
- W4229002952 cites W2104148997 @default.
- W4229002952 cites W2110812524 @default.
- W4229002952 cites W2120949068 @default.
- W4229002952 cites W2163713021 @default.
- W4229002952 cites W2164386968 @default.
- W4229002952 cites W2164494606 @default.
- W4229002952 cites W2167924062 @default.
- W4229002952 cites W2176189120 @default.
- W4229002952 cites W2216745061 @default.
- W4229002952 cites W2334783812 @default.
- W4229002952 cites W2472015174 @default.
- W4229002952 cites W2562644378 @default.
- W4229002952 cites W2593445491 @default.
- W4229002952 cites W2601068128 @default.
- W4229002952 cites W2605035747 @default.
- W4229002952 cites W2677259235 @default.
- W4229002952 cites W2694487218 @default.
- W4229002952 cites W2748606547 @default.
- W4229002952 cites W2765634094 @default.
- W4229002952 cites W2768273473 @default.
- W4229002952 cites W2792947136 @default.
- W4229002952 cites W2803398082 @default.
- W4229002952 cites W2888258413 @default.
- W4229002952 cites W2889133269 @default.
- W4229002952 cites W2893730490 @default.
- W4229002952 cites W2896647182 @default.
- W4229002952 cites W2913442468 @default.
- W4229002952 cites W2944736255 @default.
- W4229002952 cites W2956122925 @default.
- W4229002952 cites W2962705835 @default.
- W4229002952 cites W2981054348 @default.
- W4229002952 cites W2981231233 @default.
- W4229002952 cites W2998887715 @default.
- W4229002952 cites W3003649621 @default.
- W4229002952 cites W3034131339 @default.
- W4229002952 cites W3044889249 @default.
- W4229002952 cites W3048656059 @default.
- W4229002952 cites W3085845631 @default.
- W4229002952 cites W3088744430 @default.
- W4229002952 cites W3090208839 @default.
- W4229002952 cites W3093802552 @default.
- W4229002952 cites W3112221778 @default.
- W4229002952 cites W3155849427 @default.
- W4229002952 cites W3156773893 @default.
- W4229002952 cites W3157348070 @default.
- W4229002952 cites W3158414752 @default.
- W4229002952 cites W3183606541 @default.
- W4229002952 cites W3185556831 @default.
- W4229002952 cites W3187454327 @default.
- W4229002952 cites W3188027618 @default.
- W4229002952 cites W3190892937 @default.
- W4229002952 cites W3194365469 @default.
- W4229002952 cites W3195141747 @default.
- W4229002952 cites W3200680598 @default.
- W4229002952 cites W3201704679 @default.
- W4229002952 cites W3202838431 @default.
- W4229002952 cites W3204748243 @default.
- W4229002952 cites W3208210631 @default.
- W4229002952 cites W3211714291 @default.
- W4229002952 cites W4200135065 @default.
- W4229002952 cites W4205948442 @default.
- W4229002952 cites W4214603477 @default.
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- W4229002952 doi "https://doi.org/10.3389/fimmu.2022.867022" @default.
- W4229002952 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35603159" @default.
- W4229002952 hasPublicationYear "2022" @default.
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