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• W4229003247 endingPage "1490" @default.
• W4229003247 startingPage "1479" @default.
• W4229003247 abstract "Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by upper and lower motor neuron loss. The pathomechanisms of ALS are still poorly understood with current hypotheses involving genetic mutations, excitotoxicity, and reactive oxygen species formation. In the absence of a disease-altering clinically approved therapeutic, there is an ever-increasing need to identify new targets to develop drugs that delay disease onset and/or progression. The purinergic P2X7 receptor (P2X7R) has been implicated widely across the ALS realm, providing a potential therapeutic strategy. This review summarizes the current understanding of ALS, the P2X7R and its role in ALS, the current landscape of P2X7R antagonists, and the in vivo potential of these antagonists in preclinical ALS models." @default.
• W4229003247 created "2022-05-08" @default.
• W4229003247 creator A5000489720 @default.
• W4229003247 creator A5007983270 @default.
• W4229003247 creator A5013688671 @default.
• W4229003247 creator A5037765698 @default.
• W4229003247 date "2022-05-05" @default.
• W4229003247 modified "2023-10-10" @default.
• W4229003247 title "Purinergic P2X₇ Receptor: A Therapeutic Target in Amyotrophic Lateral Sclerosis" @default.
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