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- W4229007669 abstract "Evidence indicates shared physiopathological mechanisms between autism and psychosis. In this regard, the endocannabinoid system has been suggested to modulate neural circuits during the early stage of neurodevelopment, with implications for both autism and psychosis. Nevertheless, such potential common markers of disease have been investigated in both autism and psychosis spectrum disorders, without considering the conundrum of differentiating the two groups of conditions in terms of diagnosis and treatment. Here, we systematically review all human and animal studies examining the endocannabinoid system and its biobehavioral correlates in the association between autism and psychosis. Studies indicate overlapping biobehavioral aberrancies between autism and schizophrenia, subject to correction by modulation of the endocannabinoid system. In addition, common cannabinoid-based pharmacological strategies have been identified, exerting epigenetic effects across genes controlling neural mechanisms shared between autism and schizophrenia. Interestingly, a developmental and transgenerational trajectory between autism and schizophrenia is supported by evidence that exogenous alteration of the endocannabinoid system promotes progression to inheritable psychosis phenotypes in the context of biobehavioral autism vulnerability. However, evidence for a diametral association between autism and psychosis is scant. Several clinical implications follow from evidence of a developmental continuum between autism and psychosis as a function of the endocannabinoid system dysregulation." @default.
- W4229007669 created "2022-05-08" @default.
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- W4229007669 date "2022-05-05" @default.
- W4229007669 modified "2023-10-14" @default.
- W4229007669 title "The Autism–Psychosis Continuum Conundrum: Exploring the Role of the Endocannabinoid System" @default.
- W4229007669 cites W140219456 @default.
- W4229007669 cites W1547168137 @default.
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- W4229007669 cites W1924617759 @default.
- W4229007669 cites W1931140439 @default.
- W4229007669 cites W1940172302 @default.
- W4229007669 cites W1950907231 @default.
- W4229007669 cites W1964019154 @default.
- W4229007669 cites W1973352282 @default.
- W4229007669 cites W1983301798 @default.
- W4229007669 cites W2008170190 @default.
- W4229007669 cites W2009890969 @default.
- W4229007669 cites W2023962370 @default.
- W4229007669 cites W2032886183 @default.
- W4229007669 cites W2040333240 @default.
- W4229007669 cites W2046645276 @default.
- W4229007669 cites W2051221244 @default.
- W4229007669 cites W2060238106 @default.
- W4229007669 cites W2069706466 @default.
- W4229007669 cites W2074890830 @default.
- W4229007669 cites W2083075330 @default.
- W4229007669 cites W2087570876 @default.
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- W4229007669 cites W2108994842 @default.
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- W4229007669 cites W2124212695 @default.
- W4229007669 cites W2133565689 @default.
- W4229007669 cites W2137554955 @default.
- W4229007669 cites W2139338479 @default.
- W4229007669 cites W2145602532 @default.
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- W4229007669 cites W2162687166 @default.
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- W4229007669 cites W2503680544 @default.
- W4229007669 cites W2508492948 @default.
- W4229007669 cites W2525353123 @default.
- W4229007669 cites W2560317945 @default.
- W4229007669 cites W2562365749 @default.
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- W4229007669 cites W2757179846 @default.
- W4229007669 cites W2760464541 @default.
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- W4229007669 cites W2887279252 @default.
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- W4229007669 cites W2976240417 @default.
- W4229007669 cites W2998741648 @default.
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- W4229007669 cites W3013568653 @default.
- W4229007669 cites W3024654900 @default.
- W4229007669 cites W3037443245 @default.
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- W4229007669 cites W3126959679 @default.
- W4229007669 cites W3128390632 @default.
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- W4229007669 cites W3197810951 @default.
- W4229007669 cites W3199526410 @default.
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- W4229007669 doi "https://doi.org/10.3390/ijerph19095616" @default.
- W4229007669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35565034" @default.
- W4229007669 hasPublicationYear "2022" @default.
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