FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229007782> ?p ?o ?g. }

• W4229007782 endingPage "S203" @default.
• W4229007782 startingPage "S202" @default.
• W4229007782 abstract "Up to 30% of metastatic breast cancer (BC) patients (pts) develop brain metastases (BM). Prognosis of pts with BM is poor and long-term survival is rare. Identification of factors associated with long-term survival is important for improving treatment modalities. A total of 2889 out of 3234 pts of the BMBC registry were available for this analysis. Long-term survival was defined as overall survival (OS) in the upper third of the survival curve resulting in a cut-off of 15 months. 887 patients were categorized as long-term survivors. Long-term survivors compared to other pts were younger at BC and BM diagnosis (median 48 vs 54 years and 53 vs 59 years), had more often HER2+ tumors (59.1% vs 36.3%), less frequently luminal-like (29.1% vs 35.7%) or TNBC (11.9% vs 28.1%), showed better ECOG at time of BM diagnosis (ECOG 0-1 76.9% vs 51.0%), higher pCR rate (21.6% vs 13.7%) and lower number of BM (n=1 BM 40.9% vs 25.4%; n=2-3 BM 26.5% vs 26.7%; n≥4 BM 32.6% vs 47.9%) (p<0.001). Long-term survivors had less leptomeningeal metastases (10.4% vs 17.5%) and extracranial metastases (ECM, 73.6% vs 82.5%), and more often asymptomatic BM at time of BM diagnosis (26.5% vs 20.1, p<0.001). Median OS in long-term survivors was 30.9 months (95% CI 28.8-32.6) overall, 33.9 (95% CI 31.5-37.9) in HER2+, 26.9 (95% CI 25.0-30.9) in luminal-like and 26.5 (95% CI 22.7-31.2) in TNBC pts. Factors significantly associated with a categorization of long-term survivors are presented in the table below.Table: 170PMultivariate logistic regression in long-term vs short-term survivorsParameter at diagnosisCategoryOdds Ratio*95% CIp-valueAge**< 60years1≥60 years0.590.44, 0.79<0.001ECOG**0-112-40.450.33, 0.61<0.001Hormone receptorneg.1pos.1.871.39, 2.50<0.001HER2neg.1pos.2.742.06, 3.64<0.001Number of BM11<0.0012-30.790.55, 1.130.191≥40.460.33, 0.65<0.001Leptomeningeal metastasesno1yes0.990.64, 1.530.949Clinical symptoms**no1yes0.940.66, 1.340.726ECM**no1yes0.650.46, 0.930.017Chemotherapy after diagnosis of BMno1yes2.191.64, 2.92<0.001*An odds ratio ≥1 leads to a higher probability to be assigned to the group of long-term survivors** at diagnosis of BM Open table in a new tab *An odds ratio ≥1 leads to a higher probability to be assigned to the group of long-term survivors ** at diagnosis of BM Our analysis identified factors associated with long-term survival of BC pts with BM and characterized clinical features of this patient cohort. Pts with better ECOG status, younger age, lower number of BM, less extended visceral metastases are more likely to show a long-term survival and therefore are more eligible for extended local and systemic treatment." @default.
• W4229007782 created "2022-05-08" @default.
• W4229007782 creator A5000338171 @default.
• W4229007782 creator A5012926122 @default.
• W4229007782 creator A5021290996 @default.
• W4229007782 creator A5023733798 @default.
• W4229007782 creator A5026869170 @default.
• W4229007782 creator A5035116947 @default.
• W4229007782 creator A5035799597 @default.
• W4229007782 creator A5038489675 @default.
• W4229007782 creator A5040484961 @default.
• W4229007782 creator A5041988260 @default.
• W4229007782 creator A5043603003 @default.
• W4229007782 creator A5047866167 @default.
• W4229007782 creator A5057181684 @default.
• W4229007782 creator A5061581939 @default.
• W4229007782 creator A5066706392 @default.
• W4229007782 creator A5067564695 @default.
• W4229007782 creator A5067719386 @default.
• W4229007782 creator A5086791040 @default.
• W4229007782 creator A5087210400 @default.
• W4229007782 creator A5090699173 @default.
• W4229007782 date "2022-05-01" @default.
• W4229007782 modified "2023-10-01" @default.
• W4229007782 title "170P Long-term survival of breast cancer patients with brain metastases: Subanalysis of the BMBC registry" @default.
• W4229007782 doi "https://doi.org/10.1016/j.annonc.2022.03.189" @default.
• W4229007782 hasPublicationYear "2022" @default.
• W4229007782 type Work @default.
• W4229007782 citedByCount "0" @default.
• W4229007782 crossrefType "journal-article" @default.
• W4229007782 hasAuthorship W4229007782A5000338171 @default.
• W4229007782 hasAuthorship W4229007782A5012926122 @default.
• W4229007782 hasAuthorship W4229007782A5021290996 @default.
• W4229007782 hasAuthorship W4229007782A5023733798 @default.
• W4229007782 hasAuthorship W4229007782A5026869170 @default.
• W4229007782 hasAuthorship W4229007782A5035116947 @default.
• W4229007782 hasAuthorship W4229007782A5035799597 @default.
• W4229007782 hasAuthorship W4229007782A5038489675 @default.
• W4229007782 hasAuthorship W4229007782A5040484961 @default.
• W4229007782 hasAuthorship W4229007782A5041988260 @default.
• W4229007782 hasAuthorship W4229007782A5043603003 @default.
• W4229007782 hasAuthorship W4229007782A5047866167 @default.
• W4229007782 hasAuthorship W4229007782A5057181684 @default.
• W4229007782 hasAuthorship W4229007782A5061581939 @default.
• W4229007782 hasAuthorship W4229007782A5066706392 @default.
• W4229007782 hasAuthorship W4229007782A5067564695 @default.
• W4229007782 hasAuthorship W4229007782A5067719386 @default.
• W4229007782 hasAuthorship W4229007782A5086791040 @default.
• W4229007782 hasAuthorship W4229007782A5087210400 @default.
• W4229007782 hasAuthorship W4229007782A5090699173 @default.
• W4229007782 hasBestOaLocation W42290077821 @default.
• W4229007782 hasConcept C10515644 @default.
• W4229007782 hasConcept C121608353 @default.
• W4229007782 hasConcept C126322002 @default.
• W4229007782 hasConcept C141071460 @default.
• W4229007782 hasConcept C143998085 @default.
• W4229007782 hasConcept C2777910003 @default.
• W4229007782 hasConcept C530470458 @default.
• W4229007782 hasConcept C71924100 @default.
• W4229007782 hasConcept C90924648 @default.
• W4229007782 hasConceptScore W4229007782C10515644 @default.
• W4229007782 hasConceptScore W4229007782C121608353 @default.
• W4229007782 hasConceptScore W4229007782C126322002 @default.
• W4229007782 hasConceptScore W4229007782C141071460 @default.
• W4229007782 hasConceptScore W4229007782C143998085 @default.
• W4229007782 hasConceptScore W4229007782C2777910003 @default.
• W4229007782 hasConceptScore W4229007782C530470458 @default.
• W4229007782 hasConceptScore W4229007782C71924100 @default.
• W4229007782 hasConceptScore W4229007782C90924648 @default.
• W4229007782 hasLocation W42290077821 @default.
• W4229007782 hasOpenAccess W4229007782 @default.
• W4229007782 hasPrimaryLocation W42290077821 @default.
• W4229007782 hasRelatedWork W2055804777 @default.
• W4229007782 hasRelatedWork W2098891062 @default.
• W4229007782 hasRelatedWork W2159711144 @default.
• W4229007782 hasRelatedWork W2532008797 @default.
• W4229007782 hasRelatedWork W2989121736 @default.
• W4229007782 hasRelatedWork W317834158 @default.
• W4229007782 hasRelatedWork W377899687 @default.
• W4229007782 hasRelatedWork W4220726198 @default.
• W4229007782 hasRelatedWork W4239151826 @default.
• W4229007782 hasRelatedWork W2555822460 @default.
• W4229007782 hasVolume "33" @default.
• W4229007782 isParatext "false" @default.
• W4229007782 isRetracted "false" @default.
• W4229007782 workType "article" @default.