Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229010304> ?p ?o ?g. }
- W4229010304 abstract "Abstract Background Low-density lipoprotein receptor-related protein 4 (LRP4) plays a critical role in the central nervous system (CNS), including hippocampal synaptic plasticity, maintenance of excitatory synaptic transmission, fear regulation, as well as long-term potentiation (LTP). Results In this study, we found that Lrp4 was highly expressed in layer II of the piriform cortex. Both body weight and brain weight decreased in Lrp4 ECD/ECD mice without TMD (Transmembrane domain) and ICD (intracellular domain) of LRP4. However, in the piriform cortical neurons of Lrp4 ECD/ECD mice, the spine density increased, and the frequency of both mEPSC (miniature excitatory postsynaptic current) and sEPSC (spontaneous excitatory postsynaptic current) was enhanced. Intriguingly, finding food in the buried food-seeking test was prolonged in both Lrp4 ECD/ECD mice and Lrp4 cKO (conditional knockout of Lrp4 in the piriform cortex) mice. Conclusions This study indicated that the full length of LRP4 in the piriform cortex was necessary for maintaining synaptic plasticity and the integrity of olfactory function." @default.
- W4229010304 created "2022-05-08" @default.
- W4229010304 creator A5006707718 @default.
- W4229010304 creator A5007772659 @default.
- W4229010304 creator A5018277573 @default.
- W4229010304 creator A5027782089 @default.
- W4229010304 creator A5037700052 @default.
- W4229010304 creator A5046903362 @default.
- W4229010304 creator A5047870229 @default.
- W4229010304 creator A5074743331 @default.
- W4229010304 creator A5079487216 @default.
- W4229010304 creator A5083547946 @default.
- W4229010304 creator A5086111214 @default.
- W4229010304 creator A5087012443 @default.
- W4229010304 creator A5087780600 @default.
- W4229010304 date "2022-05-07" @default.
- W4229010304 modified "2023-10-15" @default.
- W4229010304 title "LRP4 is required for the olfactory association task in the piriform cortex" @default.
- W4229010304 cites W1579148076 @default.
- W4229010304 cites W1826900532 @default.
- W4229010304 cites W1910369284 @default.
- W4229010304 cites W1970256374 @default.
- W4229010304 cites W1980294445 @default.
- W4229010304 cites W1984522719 @default.
- W4229010304 cites W1991623532 @default.
- W4229010304 cites W1993479085 @default.
- W4229010304 cites W2001765460 @default.
- W4229010304 cites W2018028886 @default.
- W4229010304 cites W2035471044 @default.
- W4229010304 cites W2041911813 @default.
- W4229010304 cites W2044948946 @default.
- W4229010304 cites W2065802840 @default.
- W4229010304 cites W2074062157 @default.
- W4229010304 cites W2082745004 @default.
- W4229010304 cites W2082809168 @default.
- W4229010304 cites W2102175769 @default.
- W4229010304 cites W2102339248 @default.
- W4229010304 cites W2102790438 @default.
- W4229010304 cites W2112972217 @default.
- W4229010304 cites W2115181199 @default.
- W4229010304 cites W2117504532 @default.
- W4229010304 cites W2123491442 @default.
- W4229010304 cites W2133430149 @default.
- W4229010304 cites W2133756703 @default.
- W4229010304 cites W2143061420 @default.
- W4229010304 cites W2144696840 @default.
- W4229010304 cites W2169640526 @default.
- W4229010304 cites W2171967326 @default.
- W4229010304 cites W2286905102 @default.
- W4229010304 cites W2328230175 @default.
- W4229010304 cites W2429682989 @default.
- W4229010304 cites W2590581585 @default.
- W4229010304 cites W2617661232 @default.
- W4229010304 cites W2771044756 @default.
- W4229010304 cites W2781361993 @default.
- W4229010304 cites W2800515977 @default.
- W4229010304 cites W2811212492 @default.
- W4229010304 cites W2886225560 @default.
- W4229010304 cites W2889293584 @default.
- W4229010304 cites W2910480910 @default.
- W4229010304 cites W2938747294 @default.
- W4229010304 cites W2941309557 @default.
- W4229010304 cites W2948252395 @default.
- W4229010304 cites W2953959385 @default.
- W4229010304 cites W2982591362 @default.
- W4229010304 cites W3028888328 @default.
- W4229010304 cites W3090555570 @default.
- W4229010304 cites W3111544876 @default.
- W4229010304 cites W3119051091 @default.
- W4229010304 cites W3202135731 @default.
- W4229010304 doi "https://doi.org/10.1186/s13578-022-00792-9" @default.
- W4229010304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35526070" @default.
- W4229010304 hasPublicationYear "2022" @default.
- W4229010304 type Work @default.
- W4229010304 citedByCount "2" @default.
- W4229010304 countsByYear W42290103042023 @default.
- W4229010304 crossrefType "journal-article" @default.
- W4229010304 hasAuthorship W4229010304A5006707718 @default.
- W4229010304 hasAuthorship W4229010304A5007772659 @default.
- W4229010304 hasAuthorship W4229010304A5018277573 @default.
- W4229010304 hasAuthorship W4229010304A5027782089 @default.
- W4229010304 hasAuthorship W4229010304A5037700052 @default.
- W4229010304 hasAuthorship W4229010304A5046903362 @default.
- W4229010304 hasAuthorship W4229010304A5047870229 @default.
- W4229010304 hasAuthorship W4229010304A5074743331 @default.
- W4229010304 hasAuthorship W4229010304A5079487216 @default.
- W4229010304 hasAuthorship W4229010304A5083547946 @default.
- W4229010304 hasAuthorship W4229010304A5086111214 @default.
- W4229010304 hasAuthorship W4229010304A5087012443 @default.
- W4229010304 hasAuthorship W4229010304A5087780600 @default.
- W4229010304 hasBestOaLocation W42290103041 @default.
- W4229010304 hasConcept C105702510 @default.
- W4229010304 hasConcept C112592302 @default.
- W4229010304 hasConcept C169760540 @default.
- W4229010304 hasConcept C170493617 @default.
- W4229010304 hasConcept C17077164 @default.
- W4229010304 hasConcept C187541742 @default.
- W4229010304 hasConcept C194973443 @default.
- W4229010304 hasConcept C200170125 @default.
- W4229010304 hasConcept C201792869 @default.