FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229012703> ?p ?o ?g. }

• W4229012703 endingPage "471" @default.
• W4229012703 startingPage "465" @default.
• W4229012703 abstract "A limited number of studies have described patients on finasteride showing findings which were consistent with Peyronie’s disease (PD). We aimed to detect a pharmacovigilance signal of possible association between finasteride and PD-related clinical features. The Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) database was queried to identify the ten drugs which were associated the most with the adverse drug reactions (ADRs) recorded as “penile curvature” and/or “Peyronie’s disease”. A similar analysis, including the same drugs, was carried out for the EMA (European Medicines Agency) EudraVigilance (EV) database. Descriptive data have been analyzed, and Proportional Reporting Ratios (PRRs) have been computed against the other nine drugs of the database. Overall, 860 reports of “penile curvature” and/or “Peyronie’s disease”, were identified in the FAERS database, 214 of which (24.9%) were associated with finasteride. Most reports (56.9%) were submitted by healthcare professionals. Where a treatment-indication was stated, the vast majority of reports (176/210; 83.8%) were associated with androgenetic alopecia. The outcome of most ADRs was “serious” (82.2%), with 96 ADRs resulting in levels of permanent disability. For 97/214 individual cases, penile curvature/PD reports were not part of a syndromic cluster suggestive of post-finasteride syndrome (PFS). The PRR resulted 6.6 (95% CI: 5.6–7.8) and 11.8 (95% CI: 9.08–15.33), respectively, in the FAERS and in the EV databases. Notwithstanding the related limitations and biasing factors of pharmacovigilance studies based on spontaneous reporting, the PRR values here identified should be interpreted as strong signals of disproportionality. These findings, per se, are however not useful to confirm any causal association. Clinical studies are needed to investigate on the possible role for finasteride in causing PD-related clinical features, an hypothesis which remains highly speculative due to the very questionable quality of present data." @default.
• W4229012703 created "2022-05-08" @default.
• W4229012703 creator A5006348569 @default.
• W4229012703 creator A5009052367 @default.
• W4229012703 creator A5022737887 @default.
• W4229012703 creator A5036802793 @default.
• W4229012703 creator A5041705984 @default.
• W4229012703 creator A5056920953 @default.
• W4229012703 creator A5061623935 @default.
• W4229012703 creator A5071443011 @default.
• W4229012703 creator A5072937184 @default.
• W4229012703 creator A5075830981 @default.
• W4229012703 creator A5078706372 @default.
• W4229012703 creator A5078919686 @default.
• W4229012703 creator A5079859700 @default.
• W4229012703 creator A5081465006 @default.
• W4229012703 creator A5085174316 @default.
• W4229012703 date "2022-05-05" @default.
• W4229012703 modified "2023-10-03" @default.
• W4229012703 title "Are finasteride-related penile curvature/Peyronie’s disease Adverse Event Reports worthy of further clinical investigation? Disproportionality analysis based on both the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) pharmacovigilance databases" @default.
• W4229012703 cites W1708175277 @default.
• W4229012703 cites W1965697750 @default.
• W4229012703 cites W1967566737 @default.
• W4229012703 cites W1991993840 @default.
• W4229012703 cites W1993619850 @default.
• W4229012703 cites W2001610421 @default.
• W4229012703 cites W2011408670 @default.
• W4229012703 cites W2024986044 @default.
• W4229012703 cites W2036768532 @default.
• W4229012703 cites W2045037770 @default.
• W4229012703 cites W2050856263 @default.
• W4229012703 cites W2086049425 @default.
• W4229012703 cites W2105061671 @default.
• W4229012703 cites W2117021420 @default.
• W4229012703 cites W2126751704 @default.
• W4229012703 cites W2132059369 @default.
• W4229012703 cites W2148846485 @default.
• W4229012703 cites W2424370328 @default.
• W4229012703 cites W2567320045 @default.
• W4229012703 cites W2572464070 @default.
• W4229012703 cites W2597986029 @default.
• W4229012703 cites W2810890325 @default.
• W4229012703 cites W2888722439 @default.
• W4229012703 cites W2911357925 @default.
• W4229012703 cites W2914189181 @default.
• W4229012703 cites W2921378772 @default.
• W4229012703 cites W2960667316 @default.
• W4229012703 cites W2967797472 @default.
• W4229012703 cites W2974587430 @default.
• W4229012703 cites W3004529956 @default.
• W4229012703 cites W3047426877 @default.
• W4229012703 cites W3092578814 @default.
• W4229012703 doi "https://doi.org/10.1038/s41443-022-00568-2" @default.
• W4229012703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35513712" @default.
• W4229012703 hasPublicationYear "2022" @default.
• W4229012703 type Work @default.
• W4229012703 citedByCount "4" @default.
• W4229012703 countsByYear W42290127032022 @default.
• W4229012703 countsByYear W42290127032023 @default.
• W4229012703 crossrefType "journal-article" @default.
• W4229012703 hasAuthorship W4229012703A5006348569 @default.
• W4229012703 hasAuthorship W4229012703A5009052367 @default.
• W4229012703 hasAuthorship W4229012703A5022737887 @default.
• W4229012703 hasAuthorship W4229012703A5036802793 @default.
• W4229012703 hasAuthorship W4229012703A5041705984 @default.
• W4229012703 hasAuthorship W4229012703A5056920953 @default.
• W4229012703 hasAuthorship W4229012703A5061623935 @default.
• W4229012703 hasAuthorship W4229012703A5071443011 @default.
• W4229012703 hasAuthorship W4229012703A5072937184 @default.
• W4229012703 hasAuthorship W4229012703A5075830981 @default.
• W4229012703 hasAuthorship W4229012703A5078706372 @default.
• W4229012703 hasAuthorship W4229012703A5078919686 @default.
• W4229012703 hasAuthorship W4229012703A5079859700 @default.
• W4229012703 hasAuthorship W4229012703A5081465006 @default.
• W4229012703 hasAuthorship W4229012703A5085174316 @default.
• W4229012703 hasBestOaLocation W42290127032 @default.
• W4229012703 hasConcept C121608353 @default.
• W4229012703 hasConcept C126322002 @default.
• W4229012703 hasConcept C197934379 @default.
• W4229012703 hasConcept C2775874879 @default.
• W4229012703 hasConcept C2776235491 @default.
• W4229012703 hasConcept C2777105317 @default.
• W4229012703 hasConcept C2779134260 @default.
• W4229012703 hasConcept C2779145901 @default.
• W4229012703 hasConcept C3018890749 @default.
• W4229012703 hasConcept C41008148 @default.
• W4229012703 hasConcept C57658597 @default.
• W4229012703 hasConcept C71924100 @default.
• W4229012703 hasConcept C77088390 @default.
• W4229012703 hasConcept C98274493 @default.
• W4229012703 hasConceptScore W4229012703C121608353 @default.
• W4229012703 hasConceptScore W4229012703C126322002 @default.
• W4229012703 hasConceptScore W4229012703C197934379 @default.
• W4229012703 hasConceptScore W4229012703C2775874879 @default.
• W4229012703 hasConceptScore W4229012703C2776235491 @default.
• W4229012703 hasConceptScore W4229012703C2777105317 @default.
• W4229012703 hasConceptScore W4229012703C2779134260 @default.
• W4229012703 hasConceptScore W4229012703C2779145901 @default.

• next