Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229012722> ?p ?o ?g. }
- W4229012722 endingPage "100239" @default.
- W4229012722 startingPage "100239" @default.
- W4229012722 abstract "Pyrethroid insecticides are widely used throughout agriculture and household products. Recent studies suggest that prenatal exposure to these insecticides may adversely affect fetal development; however, little is known about the distribution of these chemicals in pregnant animals. The present study aimed to address this gap in knowledge by investigating the distribution of two commonly used pyrethroid insecticides, permethrin and α-cypermethrin, in maternal and fetal tissues of pregnant CD-1 mice. Dams were dosed from gestational days 6 to 16 via oral gavage with permethrin (1.5, 15, and 50 mg/kg), α-cypermethrin (0.3, 3, and 10 mg/kg), or corn oil vehicle. Pyrethroid levels were determined in gestational day 16 tissues collected 90 min after the final dose was administered. Across maternal tissues, levels of both pyrethroids were the highest in maternal ovaries, followed by liver and brain, respectively. In addition, levels of both pyrethroids in maternal tissues and placenta were significantly higher than those in the fetal body and amniotic fluid, suggesting that these compounds may exhibit low transfer across the mouse placenta. While additional toxicokinetic studies are needed to verify the time course of pyrethroids in the fetal compartment, these findings support investigation into indirect modes of action relevant to the effects of pyrethroids on mammalian fetal development." @default.
- W4229012722 created "2022-05-08" @default.
- W4229012722 creator A5035572491 @default.
- W4229012722 creator A5064106887 @default.
- W4229012722 creator A5066901683 @default.
- W4229012722 creator A5072658014 @default.
- W4229012722 date "2022-07-01" @default.
- W4229012722 modified "2023-10-02" @default.
- W4229012722 title "Maternal and fetal tissue distribution of α-cypermethrin and permethrin in pregnant CD-1 mice" @default.
- W4229012722 cites W101040563 @default.
- W4229012722 cites W1897412778 @default.
- W4229012722 cites W1905834091 @default.
- W4229012722 cites W1964613487 @default.
- W4229012722 cites W1980401437 @default.
- W4229012722 cites W1985673449 @default.
- W4229012722 cites W1997865872 @default.
- W4229012722 cites W2001735863 @default.
- W4229012722 cites W2010282310 @default.
- W4229012722 cites W2012665183 @default.
- W4229012722 cites W2015282567 @default.
- W4229012722 cites W2015946435 @default.
- W4229012722 cites W2020585282 @default.
- W4229012722 cites W2024567737 @default.
- W4229012722 cites W2025518612 @default.
- W4229012722 cites W2035115924 @default.
- W4229012722 cites W2036387342 @default.
- W4229012722 cites W2051009115 @default.
- W4229012722 cites W2059463168 @default.
- W4229012722 cites W2069002937 @default.
- W4229012722 cites W2069950229 @default.
- W4229012722 cites W2074281163 @default.
- W4229012722 cites W2074406308 @default.
- W4229012722 cites W2087580515 @default.
- W4229012722 cites W2091207070 @default.
- W4229012722 cites W2091860903 @default.
- W4229012722 cites W2119297620 @default.
- W4229012722 cites W2120803011 @default.
- W4229012722 cites W2128516466 @default.
- W4229012722 cites W2137002094 @default.
- W4229012722 cites W2140983699 @default.
- W4229012722 cites W2147309127 @default.
- W4229012722 cites W2152735385 @default.
- W4229012722 cites W2154769712 @default.
- W4229012722 cites W2160108008 @default.
- W4229012722 cites W2197027598 @default.
- W4229012722 cites W2250336358 @default.
- W4229012722 cites W2287666223 @default.
- W4229012722 cites W2290466312 @default.
- W4229012722 cites W2296230850 @default.
- W4229012722 cites W2309585448 @default.
- W4229012722 cites W2323588751 @default.
- W4229012722 cites W2423457805 @default.
- W4229012722 cites W2568328160 @default.
- W4229012722 cites W2593057501 @default.
- W4229012722 cites W2747037580 @default.
- W4229012722 cites W2766229511 @default.
- W4229012722 cites W2785733119 @default.
- W4229012722 cites W2793773273 @default.
- W4229012722 cites W2904073726 @default.
- W4229012722 cites W2953571394 @default.
- W4229012722 cites W2961850457 @default.
- W4229012722 cites W2967127891 @default.
- W4229012722 cites W2969474256 @default.
- W4229012722 cites W2990270751 @default.
- W4229012722 cites W2995016498 @default.
- W4229012722 cites W3012452203 @default.
- W4229012722 cites W3021481523 @default.
- W4229012722 cites W3036860629 @default.
- W4229012722 cites W3081653472 @default.
- W4229012722 cites W3138303778 @default.
- W4229012722 cites W3157006096 @default.
- W4229012722 cites W639086884 @default.
- W4229012722 doi "https://doi.org/10.1016/j.envadv.2022.100239" @default.
- W4229012722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36059860" @default.
- W4229012722 hasPublicationYear "2022" @default.
- W4229012722 type Work @default.
- W4229012722 citedByCount "3" @default.
- W4229012722 countsByYear W42290127222023 @default.
- W4229012722 crossrefType "journal-article" @default.
- W4229012722 hasAuthorship W4229012722A5035572491 @default.
- W4229012722 hasAuthorship W4229012722A5064106887 @default.
- W4229012722 hasAuthorship W4229012722A5066901683 @default.
- W4229012722 hasAuthorship W4229012722A5072658014 @default.
- W4229012722 hasBestOaLocation W42290127221 @default.
- W4229012722 hasConcept C161176658 @default.
- W4229012722 hasConcept C16685009 @default.
- W4229012722 hasConcept C172680121 @default.
- W4229012722 hasConcept C2776035571 @default.
- W4229012722 hasConcept C2776953305 @default.
- W4229012722 hasConcept C2777553912 @default.
- W4229012722 hasConcept C2778194526 @default.
- W4229012722 hasConcept C2779234561 @default.
- W4229012722 hasConcept C2779437720 @default.
- W4229012722 hasConcept C2779752676 @default.
- W4229012722 hasConcept C33070731 @default.
- W4229012722 hasConcept C42407357 @default.
- W4229012722 hasConcept C46973012 @default.
- W4229012722 hasConcept C54355233 @default.